A5100779203- Cutaneous Melanoma Detection and Management
- Aquaculture Nutrition and Growth
- Melanoma and MAPK Pathways
- Cancer Immunotherapy and Biomarkers
- Biochemical effects in animals
- Cancer-related molecular mechanisms research
- Legume Nitrogen Fixing Symbiosis
- Vitamin D Research Studies
- Ferroptosis and cancer prognosis
- Pharmacological Effects of Natural Compounds
- CAR-T cell therapy research
- Insect Pheromone Research and Control
- Glioma Diagnosis and Treatment
- PARP inhibition in cancer therapy
- Aquaculture disease management and microbiota
- Facial Nerve Paralysis Treatment and Research
- Mitochondrial Function and Pathology
- Cancer Genomics and Diagnostics
- Advanced battery technologies research
- Glutathione Transferases and Polymorphisms
- Autophagy in Disease and Therapy
- Probiotics and Fermented Foods
- Genomics, phytochemicals, and oxidative stress
- Corneal surgery and disorders
- Traditional and Medicinal Uses of Annonaceae
Kunming Medical University
2025
Ningbo Institute of Industrial Technology
2025
Chinese Academy of Sciences
2002-2025
Chongqing Medical University
2020-2025
First Affiliated Hospital of Kunming Medical University
2025
University of Chinese Academy of Sciences
2022-2025
Fuel Cells and Hydrogen
2025
Guangxi Normal University
2023-2024
Sichuan University
2023-2024
University of New Mexico
2019-2024
Abstract The stromal‐derived factor 1α/chemokine receptor 4 (SDF‐1 α /CXCR4) axis contributes to myocardial protection after infarction (MI) by recruiting endogenous stem cells into the ischemic tissue. However, excessive inflammatory macrophages are also recruited simultaneously, aggravating damage. More seriously, increased inflammation abnormal cardiomyocyte electrical coupling, leading inhomogeneities in ventricular conduction and retarded velocity. It is highly desirable selectively...
Abstract Background The role of HOX transcript antisense RNA (HOTAIR) has been proven to be important in tumorigenesis. However, how this molecule promotes metastasis and invasion PCa is still unclear. Methods relationship between HOTAIR hepatocellular adhesion (hepaCAM) was identified by immunohistochemistry, immunofluorescence, plasmid transfection, quantitative real-time PCR immunoblotting. regulatory effects on hepaCAM MAPK signalling their key roles were investigated vitro. Results...
To explore the prevalence and risk factors for myopia uncorrected in schoolchildren southern China.The government-led Shantou Myopia Study was conducted from September 2020 to June 2021. Non-cycloplegic refraction performed. Uncorrected visual acuity (UCVA) measured along with presenting if participants wore spectacles. Spherical equivalent (SER) is defined as spherical dioptres added half of cylindrical dioptres. SER <-0.50 dioptre UCVA <20/20 at least one eye.This study enrolled 724 828...
Dual-ion batteries (DIBs) were demonstrated as a promising technology for large-scale energy storage due to their low cost, recyclability, and impressively fast charge capability. Graphite commonly used cathode material in DIBs, however, suffers from poor compatibility with commercial Li-ion electrolytes graphite anodes, making it difficult directly utilize the well-established infrastructure batteries. Herein, we report small aromatic amine molecule 4,4′,4″-tris(diphenylamino)triphenylamine...
T cell receptor (TCR)-engineered cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes clinical trials against solid tumors. However, the challenge lies developing tumor-specific TCRs that avoid cross-reactivity with self-antigens to minimize possibility of severe toxicities. Current research efforts been put towards strategies eliminate TCR off-target recognition. Naive repertoire was used for screening KRASG12D-reactive TCRs. Specific were...
This study aims to investigate the significance of insulin resistance (IR) markers in predicting 48-hour hemorrhagic transformation and 3-month poor prognosis acute ischemic stroke (AIS) patients intravenous thrombolysis (IVT), with or without type 2 diabetes mellitus (T2DM). A total 1352 AIS treated IVT between January 2019 December 2023 were retrospectively reviewed. We analyzed prognostic value IR markers, including triglyceride-glucose (TyG) index, triglyceride body mass index (TYG-BMI),...
A visible-light catalyzed [3 + 1 2] annulation for the synthesis of unsymmetrical trisubstituted amino-1,3,5-triazines from amidines, isothiocyanates, and 1,1,3,3-tetramethylguanidines has been developed. This method exhibits advantages easily available starting materials, insensitive to air moisture, wide substrate scopes, high step economy, mild, metal- ligand-free conditions, which potential applications in organic, medicinal, material chemistry.
Acute myocardial infarction (AMI) is a common cardiovascular disease that can lead to necrosis and poor prognosis. Clinical practice requires an accurate quick diagnosis of AMI due the inherent limitations current biomarkers. Therefore, research into novel biomarkers necessary. We aimed explore diagnostic potency long non-coding RNA (lncRNA) N1LR SNHG1 in patients diagnosed with AMI.We measured lncRNA levels 148 50 healthy volunteers quantitative RT-PCR method. Receiver operating...
The aim of this study was to assess the efficacy and safety Bifidobacterium animalis sp. Lactis XLTG11, as an adjunctive treatment for acute watery diarrhea in children, using a randomized, double-blinded, placebo-controlled design.Eligible children with were randomly assigned into one two groups: intervention group (IG, n = 35), which received conventional plus probiotic, control (CG, only treatment. Fecal samples collected from all before after measure biochemical indices analyze gut...
Although statins are shown to have cardiac pleiotropic effects independent of lowering cholesterol, the underlying mechanism remains unclear. Mitochondrial dysfunction induced by increased fatty acid oxidation (FAO) is culprit in development hypertrophy and dysfunction. This study was explore whether atorvastatin were associated with FAO regulation, a specific focus on carnitine palmitoyltransferase 1 (CPT1). High-fat diet (HFD)-fed mice palmitic (PA)-stimulated neonatal rat primary...
Abstract Hotspot driver mutations presented by human leukocyte antigens might be recognized anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mutations, such as PIK3CA H1047L , may serve emerging targets for cancer immunotherapies. NetMHCpan V4.1 was utilized predicting neoepitopes mutation. Using in vitro stimulation, antigen-specific cells targeting the HLA-A*11:01-restricted mutation were isolated healthy donor-derived...
Numerous studies have revealed a correlation between the risk of developing diabetic nephropathy (DN) and gut microbiota (GM) composition. However, it remains uncertain whether GM composition causes DN. We aimed to explore any potential causal links A meta-analysis conducted by MiBioGen consortium largest genome-wide association study (GWAS) provided aggregated data on GM. DN were obtained from IEU database. The inverse-variance weighting (IVW) method was employed as primary analytical...