A5100699598- Cancer Immunotherapy and Biomarkers
- MRI in cancer diagnosis
- Catalytic Alkyne Reactions
- Radiomics and Machine Learning in Medical Imaging
- Nutrition and Health in Aging
- Muscle Physiology and Disorders
- Immunotherapy and Immune Responses
- Thyroid Cancer Diagnosis and Treatment
- Immune Cell Function and Interaction
- Exercise and Physiological Responses
- MicroRNA in disease regulation
- Catalytic C–H Functionalization Methods
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA modifications and cancer
- Medical Imaging Techniques and Applications
- Adipose Tissue and Metabolism
- Hepatocellular Carcinoma Treatment and Prognosis
- Autophagy in Disease and Therapy
- Acute Ischemic Stroke Management
- Lung Cancer Treatments and Mutations
- Stroke Rehabilitation and Recovery
- Cancer Genomics and Diagnostics
South China University of Technology
2021-2024
State Key Laboratory of Natural Medicine
2018-2024
Zhejiang University of Technology
2023-2024
China Pharmaceutical University
2018-2024
Wenzhou Medical University
2023-2024
West China Hospital of Sichuan University
2024
First Affiliated Hospital of Wenzhou Medical University
2024
Sichuan University
2023-2024
Chongqing Medical University
2023-2024
Southern Medical University
2022-2023
Three-carbon axial chirality has been asymmetrically established from racemic one-carbon central efficiently at room temperature: we report here the discovery of first catalytic asymmetric carbonylation readily available propargylic carbonates to access optically active 2,3-allenoates with fairly high ee. The combination [(π-allyl)PdCl]2 [(R)-ECNU-Phos], a new chiral bisphosphine ligand based on biphenyl skeleton, demonstrates enantioselectivity. Both enantiomers allenoates can be obtained...
Cancer cachexia is a kind of whole-body metabolic disorder syndrome accompanied by severe wasting muscle tissue in which cancer exosomes may be involved. Analysis clinical samples showed that the serum exosome concentrations were correlated with development cachexia. Exosomes secreted C26 cells could decrease diameter C2C12 myotubes vitro and mouse strength tibialis anterior (TA) weight vivo. GW4869, an inhibitor excretion, ameliorated tumor-bearing mice. MicroRNA (miRNA) sequencing...
Abstract Background Cancer cachexia is a multifactorial metabolic syndrome in which bile acid (BA) metabolism might be involved. The aim of the present study was to clarify contribution liver and gut microbiota BA disturbance cancer check possibility targeting using agents such as tauroursodeoxycholic (TUDCA) for therapy. Methods profiles liver, intestine, serum mice with induced by inoculation colon C26 tumour cells were analysed metabolomics methods compared that control mice. Proteomic...
Tumor-derived exosomes are emerging mediators of cancer cachexia, a kind multifactorial syndrome characterized by serious loss skeletal muscle mass and function. Our previous study had showed that microRNAs in C26 colon tumor cells were involved induction atrophy. Here, we focus on studying proteins tumor-derived which might also contribute to the development cachexia. Results comparing protein profiles cachexic non-cachexic MC38 suggested growth differentiation factor 15 (GDF-15) was rich...
Abstract Background Cancer cachexia is a multifactorial debilitating syndrome that directly accounts for more than 20% of cancer deaths while there no effective therapeutic approach treatment cachexia. Carnosol (CS) bioactive diterpene compound present in Lamiaceae spp., which has been demonstrated to have antioxidant, anti‐inflammatory, and anticancer properties. But its effects on the possible mechanism remain mystery. Methods The vitro cell models C2C12 myotube atrophy 3T3‐L1 mature...
Previous studies showed Scutellaria barbata D. Don extract (SBE) is a potent inhibitor in hepatoma and could improve immune function of H22-bearing mice. However, the immunomodulatory SBE on tumor growth remains unclear. This study aimed to investigate anti-tumor effects mice explore underlying function. The were treated by for 30 days. effect proliferation HepG2 cells vitro, transplanted tumor, cytotoxicity natural killer (NK) spleen, amount CD4+CD25+Foxp3+ Treg Th17 tissue, levels IL-10,...
Oncogenic alterations in RET occur 1-2% of non-small-cell lung cancers (NSCLCs). The efficacy and safety the first-in-class, highly selective, potent inhibitor selpercatinib Chinese patients with fusion-positive NSCLC remains unknown.In this open-label, multicenter, phase II study (NCT04280081), advanced RET-altered solid tumors received (160 mg orally twice daily) a 28-day cycle. primary endpoint was independent review committee (IRC)-assessed objective response rate (ORR; Response...
An efficient bimetallic Zn(II)/Cu(I)-mediated asymmetric synthesis of simple axially chiral allenes from terminal alkynes and aldehydes was realized by taking advantage the amine (S)-α,α-diphenylprolinol 3. This one-pot procedure is compatible with broad scopes both aldehydes, providing in practical yields an excellent enantioselectivity. Control experiments revealed that CuBr responsible for formation propargylic while combination ZnBr2 plays crucial roles amine-to-allene transformation.
A new concept for the synthesis of optically active tertiary propargylic alcohols with 90–99% ee through palladium/H<sup>+</sup>-cocatalyzed kinetic resolution was developed.
Cancer cachexia is a kind of whole body metabolic disorder syndrome accompanied with severe wasting muscle and adipose tissue. NF-κB signaling plays an important role during skeletal atrophy fat lipolysis. As inhibitor signaling, Pyrrolidine dithiocarbamate (PDTC) was reported to relieve cancer cachexia; however, its mechanism remains largely unknown. In our study, we showed that PDTC attenuated symptom in C26 tumor bearing mice models vivo without influencing volume. What's more, inhibited...
Autophagy may play an important role in the occurrence and development of glucocorticoid-induced osteonecrosis femoral head (GC-ONFH). Lithium is a classical autophagy regulator, lithium can also activate osteogenic pathways, making it highly promising therapeutic agent for GC-ONFH. We aimed to evaluate potential effect on For vitro experiments, primary osteoblasts rats were used investigating underlying mechanism lithium's protective GC-induced levels activity dysfunction. vivo rat model...
Multidrug resistance (MDR) is one of the major reasons for clinical failure cancer chemotherapy. Autophagy activation serves a crucial role in MDR. However, specific molecular mechanism linking autophagy with MDR remains unknown. The results present study demonstrated that was inhibited and microRNA (miR)‑199a‑5p levels were upregulated model lung cells (A549/T H1299/T) compared those parental cell lines. Paclitaxel (PTX) treatment increased expression miR‑199a‑5p PTX‑untreated cells, these...
Backgrounds IMPDH1, a rate-limiting enzyme in de novos synthesis of guanine nucleotides, plays an essential role the growth and progression certain tumors. However, there is still lack study on IMPDH1 evaluating its tumor immune microenvironment, potential mechanisms, as promising therapeutic target. Methods The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), Genotype-Tissue (GTEx), TIMER2.0, KM-Plotter, University Alabama at Birmingham data analysis Portal (UALCAN), cbioportal,...
The first example of Pd-catalyzed carboxylation propargylic alcohols in the presence CO (1 atm) and water affording 2,3-allenoic acids has been developed.
Abstract Hotspot driver mutations presented by human leukocyte antigens might be recognized anti-tumor T cells. Based on their advantages of tumor-specificity and immunogenicity, neoantigens derived from hotspot mutations, such as PIK3CA H1047L , may serve emerging targets for cancer immunotherapies. NetMHCpan V4.1 was utilized predicting neoepitopes mutation. Using in vitro stimulation, antigen-specific cells targeting the HLA-A*11:01-restricted mutation were isolated healthy donor-derived...
Kinetochore-localized astrin- (SPAG5-) binding protein (KNSTRN) is mainly involved in mitosis. Somatic mutations KNSTRN are known to lead the occurrence and development of certain tumors. However, role tumor immune microenvironment (TIME) as a prognostic biomarker potential therapeutic target has not been clarified. Accordingly, this study, we aimed investigate TIME. mRNA expression, cancer patient prognosis, correlations between expression component infiltration were analyzed using...
Alveolar bone injury under diabetic conditions can severely impede many oral disease treatments. Rebuilding alveolar in clinics is currently challenging due to persistent infection and inflammatory response. Here, an antibacterial DNA-based hydrogel named Agantigel developed by integrating silver nanoclusters (AgNCs) tumor necrosis factor-alpha (TNF-α) antibody into DNA promote regeneration. effectively inhibit bacterial growth through AgNCs while exhibiting negligible cytotoxicity vitro....