A5101424764- Polysaccharides and Plant Cell Walls
- Monoclonal and Polyclonal Antibodies Research
- IPv6, Mobility, Handover, Networks, Security
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Protein purification and stability
- Mobile Agent-Based Network Management
- Cancer Immunotherapy and Biomarkers
- Polysaccharides Composition and Applications
- RNA and protein synthesis mechanisms
- Wireless Networks and Protocols
- Bacteriophages and microbial interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Immune cells in cancer
- Direction-of-Arrival Estimation Techniques
- Advanced Wireless Network Optimization
- Glycosylation and Glycoproteins Research
- Bacterial Genetics and Biotechnology
- Indoor and Outdoor Localization Technologies
- Speech and Audio Processing
- Fungal Biology and Applications
- Enzyme Production and Characterization
- Mobile Ad Hoc Networks
- Wireless Communication Networks Research
China Pharmaceutical University
2016-2025
State Key Laboratory of Natural Medicine
2017-2025
University of Science and Technology of China
2023
Northeast Agricultural University
2011
Huawei Technologies (United Kingdom)
2009
Huawei Technologies (China)
2009
Brunel University of London
2002-2008
Universiti Brunei Darussalam
2007
Industrieanlagen Betriebsgesellschaft (Germany)
2006
Northwest University
2004
In this paper, we optimize the handover procedure in fast for mobile IPv6 (FMIPv6) protocol by using IEEE 802.21 media independent (MIH) services. FMIPv6 is used to enhance performance of handovers and its basic extension network mobility (NEMO), i.e., fundamental management protocols vehicular networks. With aid lower three layers' information node/router (MN/MR) neighboring access networks, tackle radio discovery candidate router (AR) issues FMIPv6. We introduce an "information element...
<italic>Sarcandra glabra</italic>(Thunb.) Nakai is a traditional Chinese herbal medicine and dietary supplement used for treating several diseases.
Abstract Tyrosine nitration of proteins is one the most important oxidative post‐translational modifications in vivo. A major obstacle for its biochemical and physiological studies lack efficient chemoselective protein tyrosine reagents. Herein, we report a generalizable strategy light‐controlled by employing biocompatible dinitroimidazole Upon 390 nm irradiation, dinitroimidazoles efficiently convert residues into 3‐nitrotyrosine peptides with fast kinetics high chemoselectivity under...
Despite the well-recognized clinical success of therapeutic proteins, especially antibodies, their inability to penetrate cell membrane restricts them secretory extracellular or membrane-associated targets. Developing a direct cytosolic protein delivery system would offer unique opportunities for intracellular target-related proteins. Here, we generated supercharged polypeptide (SCP) with high cellular uptake efficiency, endosomal escape ability, and good biosafety developed an SCP unnatural...
New Delhi metallo-β-lactmase-1 (NDM-1) has attracted extensive attention for its high catalytic activities of hydrolyzing almost all β-lactam antibiotics. NDM-1 shows relatively higher similarity to subclass B1 metallo-β-lactmases (MβLs), but residue at position 229 is identical that B2/B3 MβLs, which a Tyr instead B1-MβL-conserved Trp. To elucidate the possible role Y229 in bioactivity NDM-1, we performed mutagenesis study and molecular dynamics (MD) simulations. Although spatially distant...
Background and Purpose Chemical conjugation of therapeutic proteins with polyethylene glycol (PEG) is an established strategy to extend their biological half‐life ( t 1/2 ) a clinically useful range. We developed novel uncharged unstructured recombinant polypeptide composed five amino acids (P, S, T, A G), named PsTag, as another approach the human FGF21, increased hydrodynamic radius. Experimental Approach Human FGF21 was fused PsTag polymers differing lengths (200 ‐ 600 residues). Three...
Reliability and timely information delivery are mostly concerned in vehicular ad hoc networks (VANETs). In this paper, we propose a link Delay constrained QoS routing algorithm (DeReQ) for multimedia communications VANETs. A new reliability mathematical model which considers not only the impact of duration but also traffic density is designed. The aim DeReQ to find route reliable compliant with delay requirements. We evaluate performance through simulations our simulation results demonstrate...
We used a rat pheochromocytoma (PC 12) cell line to study the effects of salidroside on hydrogen peroxide (H2O2)-induced apoptosis. In PC12 cells, H2O2-induced apoptosis was accompanied by down-regulation Bcl-2, up-regulation Bax, release mitochondrial cytochrome c cytosol, and activation caspase-3, -8 -9. However, suppressed Bax cytosol. Moreover, attenuated -9 activation, eventually protected cells against Taken together, these results suggest that treatment with can block regulating Bcl-2...
Various natural polysaccharides are capable of activating the immune system and therefore can be employed as biological response modifiers in anti-tumor therapy. We previously found a homogenous polysaccharide from mycelium marine fungus Phoma herbarum YS4108, named YCP, exhibiting strong vivo antitumor ability via enhancement host responses. To further elucidate role YCP modifier, immunomoduating activities B cells was investigated current study. demonstrated that stimulation with murine...
Repeated amino acid sequences in proteins are widely found, and the glycine-serine-alanine repeat is an element with a general propensity to form β-sheet aggregates as found key pathological factors, several neurodegenerative diseases. Such properties of this may guide development disease-modifying therapies for disease. However, details its role underlying mechanism(s) remain largely unknown.Actions specific peptides (SNPs), especially SNP-9, on Alzheimer's disease (AD)-like abnormalities...