A5101772463- Bioactive Natural Diterpenoids Research
- Rangeland Management and Livestock Ecology
- Remote Sensing and Land Use
- Cancer-related Molecular Pathways
- Cancer Immunotherapy and Biomarkers
- Cancer, Lipids, and Metabolism
- Cell death mechanisms and regulation
- Soil Carbon and Nitrogen Dynamics
- Ferroptosis and cancer prognosis
- Melanoma and MAPK Pathways
- MicroRNA in disease regulation
- Protein Degradation and Inhibitors
- Immune cells in cancer
- CAR-T cell therapy research
- Plant-based Medicinal Research
- Traditional Chinese Medicine Analysis
- Forest, Soil, and Plant Ecology in China
- Histone Deacetylase Inhibitors Research
- Pasture and Agricultural Systems
- Remote Sensing in Agriculture
- Environmental and Agricultural Sciences
- Rangeland and Wildlife Management
- Advanced Breast Cancer Therapies
- Cancer Cells and Metastasis
- Marine Sponges and Natural Products
Beijing YouAn Hospital
2012-2024
Capital Medical University
2012-2024
Gansu Agricultural University
2005-2024
Beijing Institute of Neurosurgery
2017-2024
First Affiliated Hospital of Gannan Medical University
2021-2024
Yale University
2015-2023
Jiangnan University
2020-2021
Hunan Normal University
2021
Hunan Provincial People's Hospital
2021
University of Iowa
2020
Colorectal neoplasia differentially expressed (CRNDE) is a novel gene recognized as long noncoding RNA (lncRNA) that highly elevated in colorectal cancer and many other solid tumors but its functions on metastasis oxaliplatin (OXA) resistance are unknown. In our study, we confirmed the upregulation of CRNDE both primary specimens from patients cell lines. Knockdown expression inhibited migration invasion potency cells with no effect apoptosis. Overexpression promoted cells. Furthermore,...
DNA methyltransferase DNMT3B is frequently overexpressed in tumor cells and plays important roles during the formation progression of several cancer types. However, specific signaling pathways controlled by cancers, including melanoma, are poorly understood. Here, we report that a pro-tumorigenic role human melanoma loss dramatically suppresses Braf/Pten mouse model. Loss results hypomethylation miR-196b promoter increased expression, which directly targets mTORC2 component Rictor. RICTOR...
Abstract Tumor heterogeneity has been associated with immunotherapy and targeted drug resistance in hepatocellular carcinoma (HCC). However, communications between tumor cytotoxic cells are poorly understood to date. In the present study, thirty-one clusters of were discovered tissues adjacent through single-cell sequencing. Moreover, quantity function exhaustion was observed be induced tumors by TCR apoptosis signal pathways. Furthermore, granzyme failure HCC patients. Importantly, GZMA...
Abstract Tumor heterogeneity is a major challenge for cancer treatment, especially due to the presence of various subpopulations with stem cell or progenitor properties. In mouse melanomas, both CD34+p75− (CD34+) and CD34−p75− (CD34−) tumor were characterized as melanoma-propagating cells (MPC) that exhibit some those key features. However, these two differ from each other in tumorigenic potential, ability recapitulate heterogeneity, chemoresistance. this study, we demonstrate CD34+ CD34−...
Non-small-cell lung cancer (NSCLC) remains the leading cause of cancer-related death worldwide. Accumulating researches have highlighted ability exosome-encapsulated microRNAs (miRNAs or miRs) as potential circulating biomarkers for cancer. The current study aimed to evaluate significance mesenchymal stem cells (MSCs)-derived exosomal miR-204 in invasion, migration, and epithelial-mesenchymal transition (EMT) NSCLC cells. Initially, expression human tissues was determined by RT-qPCR, which...
Abstract Cellular senescence (CS) is closely related to tumor progression. However, the studies about CS genes across human cancers have not explored relationship between cancer signature and telomere length. Additionally, single-cell analyses revealed evolutionary trends of malignant cells immune at level. We defined a CS-associated signature, called “senescence signature”, found that patients with higher had worse prognosis. Higher was older age, genomic instability, longer telomeres,...
mitosis index of the LSC, MSC, HSC groups was greatly decreased (P < 0.05) at all time points.Any dose SC-B suppressed within 12-48 h.Compared to DMSO group, percentage cells in G0/G1 phase MSC group increased, and that S + G2M decreased, while cell inhibition (PCI) increased 0.05).This suggested could exclusively arrest phase.Cyclin D1 mRNA expression lower than 0.05).CONCLUSION: can inhibit proliferation aberrant human gastric cancer SCG-7901 vitro .This inhibitory effect may be due...
Abstract Background Stellera chamaejasme L , a traditional Chinese herb, has long been used for treatment of various tumors in the population. In our previous study, we paid an attention to cytotoxic and proapoptotic effects extracts (ESC, ESC-1 ESC-2, latter two were isolated from ESC) on 4 tumor cells (NCI-H157, NCI-H460, BEL-7402 SK-HEP-1) vitro . ESCs showed significantly inhibitory cells. ESC-2 had strongest effect broadest sensitive cell spectrum. ESC acted similar way against cells,...
Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract Stellera chamaejasme L. (ESC) was against proliferation a variety cells, but there were no studies effects ESC on EMT cells. In this study, adopted to induce HepG2 cells influence observed. MTT assay used observe cell viability. Wound healing transwell invasion activities. Western blot immunofluorescence...
To evaluate clinical treatment regularity of traditional Chinese medicine (TCM) on primary liver cancer and provide inspiration for the use.Traditional database was established to analysis classification, frequency, dosage TCM in treatment.Tonic is most common medication, herbs heat-clearing, promoting blood circulation removing stasis, eliminating dampness diuresis regulating flow Qi are more relieving exterior disorder digesting medication; first frequency single herb Atractglodis...
MicroRNAs(miRNAs)are involved in the initiation and progression of hepatocellular carcinoma. ESC, an extract Stellerachamaejasme L, had been confirmed as a potential anti-tumor Traditional Chinese Medicine. In light important role miRNAs carcinoma, we questioned whether inhibitory effects ESC on carcinoma (HCC) were associated with miRNAs.The proliferation inhibition HCC cells was measured MTT assay. The migration transwell influences growth metastasis evaluated xenograft tumor model HCC....
This research was designed to explore the variation characteristics of soil C:N:P stoichiometry and enzyme activity in Qilian Mountains different grassland types. Thus, 7 types (Upland meadow: UM, Alpine AM, Temperate steppe: ST, AS, Desert Steppe: TDS, Desert: TD, desert: AD) Natural Reserve were selected analyze activities its relationship with environmental factors. The study indicated that C/N, C/P, N/P grasslands ranged from 5.08 17.35, 2.50 72.29, 0.53 4.02.The ranking for C/N TS ≥ AM...
Potential natural vegetation (PNV) is a valuable reference for ecosystem renovation and has garnered increasing attention worldwide. However, there limited knowledge on the spatio-temporal distributions, transitional processes, underlying mechanisms of global vegetation, particularly in case ongoing climate warming. In this study, we visualize pattern inter-transition procedure PNV, analyse shifting distances directions PNV under influence climatic disturbance, explore response to...
Stellera chamaejasme L. has been widely used in the treatment of lung, liver and esophageal cancer Chinese traditional medicine. In our previous study, we found that extract (ESC) inhibited growth induced apoptosis human lung NCI-H157 cells. present investigated cellular effects an ESC-2 isolated from ESC cell line. We cells, demonstrating ESC-2-induced morphological changes cells reduced viability a dose- time-dependent manner. Furthermore, observed resulted apoptosis, activation caspase-8...
The present study was designed to investigate the synergistic inhibitory effects on hepatocellular carcinoma with recombinant human adenovirus Aspp2 (Aspp2-ad) and oxaliplatin via p53-independent pathway in vitro vivo. After being treated Aspp2-ad and/or for 24-48 h, HepG2P53-/- Hep3B cells showed a significant growth inhibition compared vehicle control. Combination group synergetic effect, rates were all above 80% at 48 h point cells. apoptotic cell numbers of treatment groups increased...
In this study, we performed a retrospective and prospective study of preoperative predictors the length stay (LOS) in three groups surgical patients conducted clinical current research status LOS prolongation under ERAS (enhanced recovery after surgery) mode, such as patient characteristics comorbidities. Information patients' exercise preferences, time, frequency duration, footwear, location knee osteoarthritis, whether there is past history injury, smoking drinking was collected, data 312...
To investigate the inhibitory and pro-apoptotic effect of Stellera Chamaejasme L extract (ESC) in vitro. ESC was first extracted with ethanol, then washed using a polyamide column 60% ethanol. decompressively recycled vacuum dried at room temperature to obtain active fractions. Subsequently, cytotoxic apoptotic effects on NCI-H157 human lung cancer cells were determined. The results showed that rich isomers Chamaejasminor, neochamaejasmine Sikokianin. had significant cytotoxicity against...