A5100637793- Hippo pathway signaling and YAP/TAZ
- Ubiquitin and proteasome pathways
- Reproductive System and Pregnancy
- Cell Adhesion Molecules Research
- Microtubule and mitosis dynamics
- Cancer-related Molecular Pathways
- Salivary Gland Disorders and Functions
- Silk-based biomaterials and applications
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cancer-related gene regulation
- Influenza Virus Research Studies
- DNA Repair Mechanisms
- Protease and Inhibitor Mechanisms
- Proteoglycans and glycosaminoglycans research
- Peptidase Inhibition and Analysis
- Fibroblast Growth Factor Research
- Polysaccharides and Plant Cell Walls
- Cystic Fibrosis Research Advances
- Connective tissue disorders research
- Pregnancy and preeclampsia studies
- S100 Proteins and Annexins
- Polysaccharides Composition and Applications
- Reproductive Biology and Fertility
- vaccines and immunoinformatics approaches
Children's Hospital of Fudan University
2021-2025
Jiangsu Agri-animal Husbandry Vocational College
2023-2025
Guangzhou Medical University
2024
Guiyang Medical University
2024
Nantong University
2024
East China Normal University
2017-2024
Affiliated Hospital of Hangzhou Normal University
2023-2024
Affiliated Hospital of Nantong University
2024
Shanghai Medical College of Fudan University
2013-2023
Fudan University
2023
Angiogenesis is an essential process involved in various physiological, including placentation, and pathological, cancer endometriosis, processes. Melatonin (MLT), a well‑known natural hormone secreted primarily the pineal gland, regulating neoangiogenesis inhibiting development of variety types, lung breast cancer. However, specific mechanism its anti‑angiogenesis activity has not been systematically elucidated. In present study, effect MLT on viability angiogenesis human umbilical vein...
TERT reactivation occurs frequently in human malignancies, especially advanced cancers. However, vivo functions of cancer progression and the underlying mechanism are not fully understood. In this study, we expressed and/or active BRAF (
Mesenchymal stem cells (MSCs) and fibroblasts are two major seed for ligament tissue engineering. To understand the effects of mechanical stimulation on these to develop effective approaches cell therapy, it is necessary investigate biological various loading conditions cells. In this study, MSCs were tested compared under a novel Uniflex/Bioflex culture system that might mimic strain in tissue. The uniaxially or radially stretched with different strains (5%, 10%, 15%) at 0.1, 0.5, 1.0 Hz....
The H9N2 avian influenza virus is widely disseminated in poultry and poses a zoonotic threat, despite vaccination efforts. Mutations at residue 198 of hemagglutinin (HA) are critical for antigenic variation receptor-binding specificity, but the underlying molecular mechanisms remain unclear. This study explores by which mutations HA site affect antigenicity, receptor binding affinity virus. Using sequence A/Chicken/Jiangsu/WJ57/2012 strain, we constructed recombinant viruses, including...
NF2-related schwannomatosis, previously known as neurofibromatosis type 2, is a genetic disorder characterized by nerve tumors due to NF2 gene mutations. Mice with Nf2 deletion develop schwannomas slowly low penetrance, hence inconvenient for preclinical studies. Here, we show that NF2, recruiting E3 ubiquitin ligases β-TrCP1/2, promotes WWC1-3 ubiquitination and degradation. In mutated cells, accumulation compensatory mechanism prevent YAP/TAZ hyperactivation rapid tumorigenesis....
Background: Cystic fibrosis (CF) is a rare disease characterized by mutations in the Fibrosis Transmembrane Receptor (CFTR) gene resulting missing or malfunctioning CFTR activity and impaired lung clearance. modulators are standard of care for CF patients; however, they not indicated approximately 10% patients due to their mutation type. By potentiating calcium-activated chloride channel TMEM16A, GDC-6988 expected compensate restore mucus hydration mucociliary clearance irrespective...
There is delicate crosstalk between fetus-derived trophoblasts (Tros) and maternal cells during normal pregnancy. Dysfunctions in interaction are highly linked to some pregnancy complications, such as recurrent spontaneous abortion (RSA), pre-eclampsia fetal growth restriction. Hyaluronan (HA), the most abundant component of extracellular matrix, has been reported act both a pro- an anti-inflammatory molecule. Previously, we that HA promotes invasion proliferation Tros by activating PI3K/Akt...
EIF3H is presumed to be a critical translational initiation factor. Here, our unbiased screening for tumor invasion factors has identified an unexpected role as deubiquitylating enzyme that dictates breast and metastasis by modulating the Hippo-YAP pathway. catalyzed YAP deubiquitylation, resulting in its stabilization. Structure-based molecular modeling simulations coupled with biochemical characterization unveiled unique catalytic mechanism dissociating polyubiquitin chains from through...
Germline alterations of the NF2 gene cause neurofibromatosis type 2, a syndrome manifested with benign tumors, and Nf2 deletion in mice also results slow tumorigenesis. As regulator Hippo signaling pathway, induces LATS1/2 kinases consequently represses YAP/TAZ. YAP/TAZ oncoproteins are inhibited by motin family proteins (Motins). Here, we show that is fine-tuned Motins NF2-dependent manner, which recruits E3 ligase RNF146 to facilitate ubiquitination subsequent degradation Motins. In...
Rapid and strong adhesion of hydrogel adhesives is required for instant wound closure hemostasis. However, in situ formation sufficient at target tissue sites biological environments are severely compromised by the presence blood body fluids. In this work, an underwater adhesive (named SHCa) fabricated with rapid gelation, enhanced mechanical toughness, robust adhesion. The SHCa can undergo UV irradiation-induced gelation under water within 5 s adhere firmly to surfaces 6 months. synergistic...
The follicular microenvironment, including intra-follicular granulosa cells (GCs), is responsible for oocyte maturation and subsequent ovulation. However, the functions of GCs cellular components microenvironment in preovulatory follicles have not been extensively explored. Here, we surveyed single-cell transcriptome around MII oocytes six human vitro fertilization. There were different cell types follicles, various immune cells. In GCs, identified nine functional clusters with...
Abstract WWC1 regulates episodic learning and memory, genetic nucleotide polymorphism of is associated with neurodegenerative diseases such as Alzheimer’s disease. However, the molecular mechanism through which neuronal function has not been fully elucidated. Here, we show that its paralogs (WWC2/3) bind directly to angiomotin (AMOT) family proteins (Motins), recruit USP9X deubiquitinate stabilize Motins. Deletion WWC genes in different cell types leads reduced protein levels In mice,...
Human epidermal growth factor receptor 2 (HER2)-positive breast cancer accounts for about 20% of all cases and is correlated with a high relapse rate poor prognosis. ADAMTS18 proposed as an important functional tumor suppressor gene involved in multiple malignancies, including cancer. It functions extracellular matrix (ECM) modifier. However, it remains unclear whether affects mammary tumorigenesis malignant progression through its essential ECM regulatory function.
Abstract Dissolving the lipid droplets in tissue section with alcohol during a hematoxylin and eosin (H&E) stain causes tumor cells to appear like clear soap bubbles under microscope, which is key pathological feature of cell renal carcinoma (ccRCC). Mitochondrial dynamics have been reported be closely associated metabolism development. However, relationship between mitochondrial reprogramming ccRCC remains further explored. We conducted bioinformatics analysis identify genes regulating...
Abstract Sorafenib, an anticancer drug, has been shown to induce ferroptosis in cancer cells. However, resistance sorafenib greatly limits its therapeutic efficacy, and the exact mechanism of is not fully understood. This study investigated role N‐Acetyltransferase 10 (NAT10) influencing activity nasopharyngeal carcinoma (NPC) molecular mechanism. NAT10 expression was significantly upregulated NPC. Mechanistically, promotes proteins solute carrier family 7 member 11 (SLC7A11) through ac4C...
Platinum resistance may be attributable to inherent or acquired proficiency in homologous recombination repair (HRR) epithelial ovarian cancer (EOC). The objective of this study was evaluate the efficacy small molecule inhibitor triapine disrupt HRR and sensitise BRCA wild-type EOC cells platinum-based combination therapy vitro vivo. sensitivity olaparib, cisplatin, carboplatin, doxorubicin, etoposide with evaluated by clonogenic survival assays. effects on activity were measured a DR-GFP...
ADAMTS18 is a novel tumor suppressor and critical to the pathology of human colorectal cancer. However, underlying mechanism not clear. Here we generated an Adamts18-deficient mouse strain as in vivo model investigate role pathogenesis In AOM/DSS-induced colitis-associated cancer, deficiency Adamts18 mice resulted enhanced tumorigenesis colon inflammation that could be attributed part nuclear translocation β-catenin elevated expression its downstream target genes, cyclin D1 c-myc. Moreover,...