A5100605220- Acute Ischemic Stroke Management
- Endometriosis Research and Treatment
- Reproductive System and Pregnancy
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Tryptophan and brain disorders
- Protease and Inhibitor Mechanisms
- Lipoproteins and Cardiovascular Health
- Uterine Myomas and Treatments
- Cerebrovascular and genetic disorders
- Testicular diseases and treatments
- Circadian rhythm and melatonin
- Receptor Mechanisms and Signaling
- Neurological Disease Mechanisms and Treatments
- Peripheral Artery Disease Management
- Neonatal and fetal brain pathology
- Apelin-related biomedical research
- Inflammatory Biomarkers in Disease Prognosis
- Neuroendocrine regulation and behavior
- Ovarian cancer diagnosis and treatment
- Stroke Rehabilitation and Recovery
- Blood Coagulation and Thrombosis Mechanisms
- Neurological Disorders and Treatments
- Peroxisome Proliferator-Activated Receptors
- Traumatic Brain Injury and Neurovascular Disturbances
Obstetrics and Gynecology Hospital of Fudan University
2016-2024
Weatherford College
2022
Nanjing Medical University
2013-2021
Shanghai Medical College of Fudan University
2018-2020
Shanghai Institute of Planned Parenthood Research
2018
Angiogenesis is an essential process involved in various physiological, including placentation, and pathological, cancer endometriosis, processes. Melatonin (MLT), a well‑known natural hormone secreted primarily the pineal gland, regulating neoangiogenesis inhibiting development of variety types, lung breast cancer. However, specific mechanism its anti‑angiogenesis activity has not been systematically elucidated. In present study, effect MLT on viability angiogenesis human umbilical vein...
There is uncertainty surrounding the differences in outcomes after intracerebral haemorrhage (ICH) between men and women. This study aimed to investigate sex clinical characteristics, severity of Chinese ICH patients. The Nanjing First Hospital stroke registry was a hospital-based patients with 1-year prospective follow-up. From 2004 2008, total 651 consecutively recruited acute were enrolled. Primary outcome death or dependency defined as modified Rankin Scale score 3-6 at 12 months....
Endometriosis is a common gynecological disease and the pathogenesis not clearly understood. Previous studies have demonstrated via microarray techniques that microRNA (miR)‑449b was significantly downregulated both in ectopic eutopic endometrium patients with endometriosis. In present study, aberrant expression of miR‑449b further confirmed by reverse transcription‑quantitative polymerase chain reaction. It miR‑449b‑3p tissues from women endometriosis, same pattern observed endometrial...
To explore whether the thrombospondin-1(TSP1)-CD47-signal regulatory protein alpha (SIRPα) signaling pathway has impacts on development of endometriosis.Endometrial stromal cells (ESCs) originated from ectopic and eutopic endometrial tissues with or without endometriosis. Monocytes (Macrophages) were isolated peripheral blood peritoneal fluids The expression levels molecules investigated by flow cytometry (FCM), immunohistochemistry (IHC), RT-qPCR. concentration TSP1 was assessed via ELISA....
In patients with severe carotid artery stenosis, the effects of reopening, achieved either by endarterectomy (CEA) or stenting (CAS), on cognitive functions remain elusive. Herein, we conducted a prospective study to determine whether and what extent CEA CAS affected performance. Patients admitted Department Neurology Vascular Surgery in Nanjing First Hospital from December 2012 March 2015 diagnosis stenosis (>70%) were included study. Among them, 77 underwent CEA, 81 CAS, who refused...
Abstract The presence of extensive infiltrated macrophages with impaired phagocytosis is widely recognised as a significant regulator for the development endometriosis (EMs). Nevertheless, metabolic characteristics and fundamental mechanism macrophage are yet to be clarified. Here, we observe that there decreased expression haematopoietic cellular kinase (HCK) in peritoneal fluid from EMs patients, which might attributed high oestrogen hypoxia condition. Of note, HCK deficiency resulted...
Abstract Background and Purpose: To investigate the association of neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte (PLR) lymphocyte-monocyte (LMR) with post-thrombolysis early neurological outcomes including improvement (ENI) deterioration (END) in patients acute ischemic stroke (AIS). Methods: AIS undergoing intravenous thrombolysis were enrolled from April 2016 to September 2019. Blood cell counts sampled before thrombolysis. Post-thrombolysis END was defined as National Institutes...
Background: Mounting evidence has shown that mechanical thrombectomy (MT) improves clinical outcomes for large vessel occlusions (LVOs) in patients with acute ischemic stroke (AIS) of the anterior circulation. The present study aimed to provide a comprehensive analysis risk factors associated AIS receiving MT. Methods: A total 212 consecutive who underwent MT were enrolled study. Clinical characteristics recorded at admission. Two endpoints defined according 3-month modified Rankin scale...
Objective To intestate the effect of different doses atorvastatin on early neurological deterioration and short-term outcomes in patients with acute ischemic stroke.Methods The stroke were enrolled prospectively.They randomly assigned to either a standard therapy group (atorvastatin 20 mg/d) or an intensive treatment 40 mg/d).The primary within 1 week good outcome evaluation at month after (the modified Rankin Scale score 0-2); secondary National Institutes Health Stroke (NIHSS) adverse...