A5103325647- Lung Cancer Treatments and Mutations
- Lung Cancer Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Lung Cancer Research Studies
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Estrogen and related hormone effects
- Radiomics and Machine Learning in Medical Imaging
- Gastrointestinal Tumor Research and Treatment
- HER2/EGFR in Cancer Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Quinazolinone synthesis and applications
- Cancer-related molecular mechanisms research
- Pleural and Pulmonary Diseases
- Synthesis and biological activity
- Esophageal Cancer Research and Treatment
- RNA modifications and cancer
- Breast Lesions and Carcinomas
- Peptidase Inhibition and Analysis
- Potassium and Related Disorders
- Chemical Reactions and Isotopes
- Artificial Intelligence in Healthcare and Education
- Advanced X-ray and CT Imaging
- PI3K/AKT/mTOR signaling in cancer
- Cancer Mechanisms and Therapy
Tianjin Medical University Cancer Institute and Hospital
2012-2024
Southern University of Science and Technology
2024
Guangzhou Medical University
2024
Shanghai University
2024
First Affiliated Hospital of Zhengzhou University
2022-2024
Nanjing Drum Tower Hospital
2020-2023
Sichuan University
2023
State Key Laboratory of Oral Diseases
2023
Zhejiang University
2023
Bengbu Medical College
2023
Recent clinical data have linked KRAS/TP53 comutation (mut) to resistance radiotherapy (RT), but supporting laboratory in vivo evidence is lacking. In addition, the ability of different radiation doses, with/without epidermal growth factor receptor (EGFR)-directed treatment, achieve local tumor control as a function KRAS status unknown. Here, we assessed clonogenic survival panel annotated lung cancer cell lines. KRASmut/TP53mut was associated with highest radioresistance nonisogenic and...
Abstract Background Epidermal growth factor receptor (EGFR) mutations are key drivers in a significant portion of non‐small‐cell lung cancer (NSCLC) patients. While third‐generation EGFR‐tyrosine kinase inhibitors (TKIs) such as osimertinib have demonstrated efficacy, the management patients who continue to experience disease progression during treatment remains challenging. The emergence drug resistance, including development secondary mutations, necessitates exploration alternative...
Computed tomography (CT), an efficient radiological technology, is used to detect lung cancer in the clinic. Carcinoembryonic antigen (CEA), a common tumor biomarker, applied detection of various tumors. To highlight advantages two-dimensional techniques and assist clinicians optimizing diagnostic schemes, we established favorable model combining CT CEA. In study, univariate analysis was performed screen independent predictors training cohort 271 patients with malignant pulmonary nodules...
// Xiaoliang Zhao 1, 2, 3, 4 , Yanjun Su Jian You Liqun Gong Zhenfa Zhang Meng Wang Zhenqing Zhen Xiaolin Li Changli 1 Department of Lung Cancer, Tianjin Medical University Cancer Institute and Hospital, 300060, P.R. China 2 Center, P.R 3 Key Laboratory Prevention Therapy, National Clinical Research Center for Correspondence to: Wang, email: wangchangli@medmail.com.cn Keywords: recombinant human endostatin, neoadjuvant chemotherapy, non-small cell lung cancer Received: March 10, 2016...
In patients with severe carotid artery stenosis, the effects of reopening, achieved either by endarterectomy (CEA) or stenting (CAS), on cognitive functions remain elusive. Herein, we conducted a prospective study to determine whether and what extent CEA CAS affected performance. Patients admitted Department Neurology Vascular Surgery in Nanjing First Hospital from December 2012 March 2015 diagnosis stenosis (>70%) were included study. Among them, 77 underwent CEA, 81 CAS, who refused...
To compare survival of patients with non-small cell lung cancer (NSCLC) who underwent surgical resection and lymph node sampling based on guidelines proposed by the American College Surgeons Oncology Group (ACOSOG), National Comprehensive Cancer Network (NCCN), OSI Pharmaceutical RADIANT trial, International Association for Study Lung (IASLC). Medical records NSCLC from 2001 to 2008 at our hospital were reviewed. Staging was according 7th edition AJCC TNM classification cancer. Patients...
4040 Background: PD-1 inhibitor and chemotherapy have shown significant clinical benefits in 1L-treatment of G/GEJ. While it is not clear for locally advanced stage. The aim this single-arm phase Ib trial to assess the feasibility sintilimab (PD-1 inhibitor) combination with cCRT GC. Methods: Patients (pts) initial histopathologically confirmed G/GEJ adenocarcinoma, diagnosed as III-IVA per AJCC 8 th ECOG PS 0-1 were eligible. Sintilimab (200mg, iv, Q3W) was given CRT sandwich sequence one...
Objectives The safety and feasibility of repeat biopsy after systemic treatment for non-small cell lung cancer have received extensive attention in recent years. purpose this research was to compare complication rates between initial rebiopsy patients with progressive disease assess risk factors clinical results rebiopsy. Methods study included 113 initially diagnosed who underwent at progression while on epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) and/or...
Neoadjuvant immunochemotherapy is effective in resectable NSCLC. However, its role unresectable stage IIIB NSCLC patients remains controversial. This study aimed to demonstrate the efficacy and safety of neoadjuvant followed by surgical resection treat initial patients.This retrospectively analyzed 59 who received induction pembrolizumab combined with chemotherapy between June 2019 April 2022. Clinical characteristics, radiological pathological responses, survival outcomes were collected...
Abstract Background Lymph node (LN) metastasis is the most common route in gastric cancer. Extensive dissection of LNs can significantly improve prognosis patients with Recently, multiple clinical studies have demonstrated that either indocyanine green (ICG) or carbon nanoparticles (CNs) assist to promote during laparoscopic radical gastrectomy. Considering pros and cons two tracers, this study proposed a novel method dual tracer (ICG combined CNs) for lymphatic tracing cancer surgery....
A clinical diagnostic model of gastric low-grade intraepithelial neoplasia (LGIN) was developed and validated to improve the identification precancerous lesions in cancer.A retrospective analysis 1211 patients with chronic atrophic gastritis (CAG) 1089 LGIN admitted Endoscopy Center First Affiliated Hospital Bengbu Medical College from January 2016 December 2021 performed record basic pathological information.A total 1756 were included after screening divided unequally randomly into 2...
To investigate the prognostic significance of station 4R lymph node (LN) dissection in patients who underwent operations for right primary non-small cell lung cancer (NSCLC).We performed a retrospective study involving with NSCLC received lobotomy or pneumonectomy mediastinal LN between January 2011 and December 2017. Propensity score matching was performed. Disease-free survival (DFS) overall (OS) were compared without dissection.Our included 2070 patients, 207 having no (S4RD- group) 1863...
Abstract Background The 5‐year survival rate of non‐small cell lung cancer (NSCLC) is only 15%. Screening some combined gene mutations could predict the NSCLC patients and also provide new ideas for diagnosis treatment NSCLC. present study aimed to identify signature prediction Methods Clinical mutation information 949 was downloaded from TCGA. High frequency common genes were analyzed based on 1000 related genes. LASSO‐COX model used screen points analyze their survival, then a established....
Abstract Background The majority of previous studies the clinical outcome video‐assisted thoracoscopic surgery (VATS) versus open lobectomy for pathological N2 non‐small cell lung cancer (pN2 NSCLC) have been single‐center experiences with small patient numbers. aim this study was therefore to investigate these procedures but in a large cohort Chinese patients NSCLC real‐world conditions. Methods Patients who underwent pN2 by either VATS or thoracotomy were retrospectively reviewed from 10...
Adjuvant chemotherapy is used as an alternative treatment for non-small cell lung cancer (NSCLC); however, the efficiency of post-pneumonectomy adjuvant in NSCLC has not been clarified. In present study, patients who benefited from with TP/NP/GP were identified. A total 217 underwent pneumonectomy identified this study. Of these, 87 combined (TP/NP/GP regimen) and 130 only initial management. The primary endpoint study was overall survival. Actuarial survival analysis conducted using...
Abstract Background The clinical application of robotic-assisted gastrectomy remains controversial, especially as studies this operation navigated by carbon nanoparticle suspension injection (CNSI) have not been conducted. This study aims to assess the perioperative safety and efficacy CNSI-guided in patients with gastric cancer focusing on short-term outcomes. Methods A retrospective analysis who underwent laparoscopic or a pathological diagnosis was Data demographics, surgical management,...
Abstract Background It is well established that retrieved lymph node (RLN) counts were positively correlated with better overall survival in gastric cancer (GC). But little known about the relationship between RLN count and short-term complications after radical surgery. Methods A total of 1487 consecutive GC patients January 2016 December 2018 at Nanjing Drum Tower Hospital retrospectively analyzed. Univariate analyses performed to elucidate association postoperative complications. We...
BACKGROUND Whether nab-paclitaxel plus carboplatin as neoadjuvant therapy can benefit patients with resectable squamous cell carcinoma of the lung remains unclear. This prospective study aimed to investigate outcomes in stage IIIA-N2 treated therapy. MATERIAL AND METHODS Patients were (100 mg/m², days 1, 8, and 15) (5 mg/(mL·min), day 1) for two 21-day cycles. The followed every 3 months 2 years 6 after that. primary endpoint was downstaging rate. Secondary endpoints included objective...