A5009512812- Lipoproteins and Cardiovascular Health
- Antiplatelet Therapy and Cardiovascular Diseases
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Gastrointestinal Tumor Research and Treatment
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Treatments and Mutations
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Blood Pressure and Hypertension Studies
- Gastric Cancer Management and Outcomes
- Reproductive System and Pregnancy
- Cardiac Imaging and Diagnostics
- Peripheral Artery Disease Management
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Endometriosis Research and Treatment
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Disease and Adiposity
- Cardiac Health and Mental Health
- Multiple Myeloma Research and Treatments
- Peptidase Inhibition and Analysis
- Uterine Myomas and Treatments
- Helicobacter pylori-related gastroenterology studies
Chengdu University of Traditional Chinese Medicine
2025
Takeda (United States)
2021-2024
California Institute for Biomedical Research
2023-2024
Scripps Research Institute
2018-2024
Kaohsiung Chang Gung Memorial Hospital
2018-2024
Chang Gung University
2012-2024
Zhoukou Normal University
2024
Guangzhou Medical University
2023
Shanghai First People's Hospital
2013-2023
Shanghai Jiao Tong University
2023
Patients with stable coronary artery disease and diabetes mellitus who have not had a myocardial infarction or stroke are at high risk for cardiovascular events. Whether adding ticagrelor to aspirin improves outcomes in this population is unclear.
In the phase 3 study entitled ALK in Lung cancer Trial of brigAtinib 1st Line (ALTA-1L), which is a brigatinib inhibitor-naive advanced ALK-positive NSCLC, exhibited superior progression-free survival (PFS) versus crizotinib two planned interim analyses. Here, we report final efficacy, safety, and exploratory results.Patients were randomized to 180 mg once daily (7-d lead-in at 90 daily) or 250 twice daily. The primary end point was blinded independent review committee-assessed PFS. Genetic...
Guidelines for patients with atherosclerotic cardiovascular disease (ASCVD) recommend intensive statin therapy and adding nonstatin if low-density lipoprotein cholesterol (LDL-C) levels are 70 mg/dL or more. Compliance guidelines is often low.
Background: Despite growing recognition of type 2 myocardial infarction (T2MI; related to supply/demand mismatch), little is known about its risk factors or association with outcome. Methods: A single-center cohort patients undergoing coronary peripheral angiography without intervention was prospectively enrolled and followed for incident 1 T2MI, major adverse cardiovascular events (MACE, a composite all-cause death, nonfatal [MI], heart failure, stroke, transient ischemic attack, arterial...
Abstract Hypoalbuminemia is a common finding and independent predictor for unfavorable prognosis. The prognostic value of albumin measurement short‐term VTE prediction in hospitalized patients remains unclear. In the APEX trial ( ClinicalTrials.gov identifier: NCT01583218), medical inpatients were randomized to receive either extended‐duration betrixaban or shorter‐duration enoxaparin followed 77 days. Baseline concentrations obtained 7266 subjects with evaluable endpoints. association...
There remains a need to develop novel SARS-CoV-2 therapeutic options that improve upon existing therapies by an increased robustness of response, fewer safety liabilities, and global-ready accessibility. Functionally critical viral main protease (Mpro, 3CLpro) is attractive target due its homology within the coronaviral family, lack thereof toward human proteases. In this disclosure, we outline advent 3CLpro inhibitor, CMX990, bearing unprecedented trifluoromethoxymethyl ketone warhead....
To investigate relationships between glycated haemoglobin (HbA1c) and reported hypoglycaemia risk of major adverse cardiovascular events (MACE).The EXAMINE trial randomized 5380 patients with type 2 diabetes (T2DM) a recent acute coronary syndrome (ACS) event, in 49 countries, to double-blind treatment alogliptin or placebo addition standard care. We used Cox proportional hazards models analyse among MACE, HbA1c levels hypoglycaemic events.Patients achieved lower than the group all baseline...
Neurotensin is a peptide whose receptor (sortilin 1) linked to cardiovascular disease (CVD) development. We hypothesized concentrations of proneurotensin (stable profragment neurotensin) would predict incident events in community-based subjects.Blood samples from 3439 participants the Framingham Heart Study (FHS) Offspring cohort (mean age 59.2 years, 47.1% male) were tested for proneurotensin. Primary outcome interest was hard CVD (myocardial infarction, stroke, and death); interaction...
Background Improved heart failure ( HF ) risk stratification after a recent acute coronary syndrome may identify those who can benefit from therapies that reduce risk. We aimed to clinical and biomarker predictors for expanded outcomes in patients with type 2 diabetes mellitus syndrome. Methods Results The EXAMINE Ex amination of Cardiovascular Outcomes Alogliptin versus Standard Care) trial was multicenter, non‐inferiority, double‐masked, placebo‐controlled study which randomized 5380...
Surgery of gastrointestinal stromal tumors (GISTs) has been modified, and laparoscopic resection GIST gained improvement roles.We retrospectively reviewed clinical data oncological outcomes our patients who underwent surgery traditional open surgery. In total, 227 pathologically diagnosed cases were in Chang Gung Memorial Hospital at Linkou, Taipei, Taiwan, between 2005 2010. We excluded those with tumor size >5 cm, biopsy-only, combined other operation, endoscopic mucosal resection, located...
It is well established that embryonic chromosomal abnormalities (both in the number of chromosomes and structure) account for 50% early pregnancy losses. However, little known regarding potential differences incidence distribution between patients with sporadic abortion (SA) recurrent loss (RPL), let alone role submicroscopic copy-number variations (CNVs) these cases. The aim present study was to systematically evaluate CNVs etiology RPL compared SA. Over a 3-year period, 1556 fresh products...
We sought to assess the risk of major adverse cardiovascular events (MACE) by utilizing high-sensitivity C-reactive protein (hsCRP) level and low-density lipoprotein cholesterol (LDL-C) in patients with type 2 diabetes recent acute coronary syndrome.
Endometriosis (EMS) is a chronic inflammatory disease characterized by the presence of extrauterine endometrial tissues. It has been previously reported that refluxed blood containing viable tissues and defective elimination peritoneal macrophages in pelvic cavity may involve EMS pathogenesis. However, mechanism which exhibit attenuated phagocytic capability remains undetermined. Herein, we found heme, byproduct lysed erythrocytes, accumulated abnormally fluid (PF) patients with (14.22...
Work-family conflict has gained a growing amount of attention in the field workplace stress, which can negatively impact employee health. equilibrium is difficult to maintain contemporary industrialized societies due rising demands both and home. This study relied on self-determination theory, conservation resources psychological safety, innovative human resource management practices, social exchange theory. It investigates impacts work-family well-being safety. also indirect effects...
To investigate adiponectin levels and cardiovascular (CV) outcomes in patients with diabetes recent acute coronary syndrome (ACS).