A5101841493- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Cancer-related gene regulation
- Protease and Inhibitor Mechanisms
- Air Quality and Health Impacts
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Inflammatory Bowel Disease
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Machine Learning in Bioinformatics
- Air Quality Monitoring and Forecasting
- Immune cells in cancer
- Blood Coagulation and Thrombosis Mechanisms
- MicroRNA in disease regulation
- Histone Deacetylase Inhibitors Research
- Fibroblast Growth Factor Research
- Flood Risk Assessment and Management
- Eosinophilic Disorders and Syndromes
- Protein Structure and Dynamics
- Plant pathogens and resistance mechanisms
- Cancer Mechanisms and Therapy
- Gestational Diabetes Research and Management
- Computational Drug Discovery Methods
Air Force Medical University
2025
Soochow University
2017-2024
First Affiliated Hospital of Soochow University
2017-2024
Xinyang Normal University
2021-2022
First Affiliated Hospital of Xi'an Jiaotong University
2022
Affiliated Hospital of Shaanxi University of Chinese Medicine
2022
Tianjin Medical University
2022
Sir Run Run Shaw Hospital
2022
Zhejiang University
2022
Zhongshan Hospital
2022
Abstract The specific mechanisms underlying bacteria‐triggered cell death and osteogenic dysfunction in host bone marrow mesenchymal stem cells (BMSCs) remain unclear, posing a significant challenge to the repair of infected defects. This study identifies ferroptosis as predominant cause BMSCs microenvironment. Mechanistically, bacteria‐induced activation innate immune response leads upregulation phosphorylation interferon regulatory factor 7 (IRF7), thus facilitating IRF7‐dependent through...
Rationale: Mesenchymal stem cells (MSCs) possess potent immunomodulatory capability, but occasionally, clinical application of MSCs is hindered by compromised cell functionality and insufficient therapeutic efficacy. Methods: Here, well-established mouse models dextran sulfate sodium (DSS)-induced colitis streptozotocin (STZ)-induced type 1 diabetes (T1D) were used to evaluate effects human umbilical cord-derived MSCs. examined at the fifth (P5) fifteenth (P15) passages, three-dimensional...
Hypermethylation of the opioid binding protein/cell adhesion molecule-like (OPCML) gene is frequently observed in ovarian carcinoma. We evaluated detection circulating hypermethylated OPCML for detecting carcinoma and assessing its prognosis.We studied 85 tissue samples including 45 cancer tissues 40 normal blood from patients 20 healthy individuals. Bisulfite sequencing methylation-sensitive restriction enzyme-PCR (MSRE-PCR) were used to detect frequency hypermethylation.We detected that...
Lung cancer is a devastating with high morbidity and mortality. Ubiquitin‑specific protease (USP) type of deubiquitinating enzyme (DUB) that has been implicated in numerous cancers, including colorectal, myeloma breast. In the present study, expression USP51 was determined lung cell line A549 cisplatin (also known as DDP)‑resistant strain A549/DDP. The zinc‑finger E‑box binding homeobox 1 (ZEB1), transcriptional repressor, also examined. effects knockdown or overexpression on proliferation...
Subarachnoid hemorrhage (SAH) is a common disease with high morbidity and mortality, which can cause pathological, physiological, biological reactions. SAH causes series of responses such as neuronal cerebral cortex damage, in turn leads to inflammation apoptosis. Traditional Chinese medicine has strong anti-inflammatory effect, Alantolactone (ATL). However, studies on ATL therapy for have not been reported. We observed the neurological scores, brain water content, Evans blue (EB)...
Stroke is an extremely complicated disease caused by multiple factors. Epidemiological studies have shown that genetic factors contribute to the pathogenesis of stroke. There still little research on effect ApoB gene stroke in Chinese Han population. The purpose our was explore polymorphism susceptibility Ischemic male population.7 polymorphisms were selected and genotyped using Sequenom MassARRAY 325 ischemic patients 399 healthy controls association between performed χ2 test, model...
Ischemic stroke is one of the most common diseases with a high burden neurological deficits, disability and death. Zinc finger protein 208 (ZNF208) was found to be involved in coronary heart disease, although little information available about its association ischemic stroke. We performed present case-control study clarify between single-nucleotide polymorphisms (SNPs) within ZNF208 risk southern Chinese Han population.A total 799 subjects (400 cases 399 healthy controls) were enrolled...
// Tie Guo 1 , Haizhen Hao Lv Zhou Feng and Dan Yu Haikou Hospital of Xiangya Medical College Central South University, Haikou, Hainan 570208, China Correspondence to: Yu, email: yudancsu@hotmail.com Keywords: TIMP-2; single-nucleotide polymorphisms; large artery atherosclerotic stroke; southern Chinese Han population Received: November 14, 2017 Accepted: December 05, Published: 18, 2017 ABSTRACT Tissue inhibitor matrix metalloproteinase 2 (TIMP-2) regulates the...
Lung cancer is the most frequent type of affecting both men and women globally, it associated with a high mortality rate. It clinically treated cisplatin, platinum-based drug that works by generating DNA lesions, which activates damage response induces cell death. However, chemoresistance cells limits clinical usefulness cisplatin as an anticancer drug. Here, we uncovered role ubiquitin-specific protease 51 (USP51) in chemosensitivity lung to regulating response. USP51 was more upregulated...
Chronic obstructive pulmonary disease (COPD) is one of the leading causes morbidity and death worldwide. It characterized by chronic inflammation obstructed airflow from lungs. To date, there no effective treatment for COPD. The activation agrin (AGRN-YAP pathway can promote heart regeneration. Because induce only mild cardiomyocyte proliferation compared with ERBB2 activation, it might exert pleiotropic effects, such as mitigation innate inflammation, immune response, fibrosis. Previously,...
Terriera angularis , a new species of that develops on leaves Illicium simonsii was collected from Shennongjia forestry region Hubei Province, China. Description, illustration, and comments are given for this fungus. The type collection is deposited in the Reference Collection Forest Fungi Anhui Agricultural University, China (AAUF).
Economic development is responsible for excessive sulfur dioxide (SO2) emissions, environmental pressure increases, and human risks. This study used spatial autocorrelation, the Environmental Kuznets Curve (EKC), Logarithmic Mean Divisia Index model to spatiotemporal variation characteristics influencing factors of SO2 emissions in Yangtze River Belt (YREB) from 1997 2017. Our results show that total YREB rose 513.14 × 104 t 974.00 before dropping 321.97 t. The 11 provinces first increased...
Long non‑coding RNAs (lncRNAs) are functional components of the human genome. Recent studies have demonstrated that lncRNAs play essential roles in tumorigenesis, and involved cell proliferation, apoptosis, migration invasion several types tumor, including lung cancer. However, clinical relevance lncRNA expression cancer remains unknown. The aim present study was to investigate pattern RFPL3 antisense (RFPL3S) its associations with clinicopathological characteristics patients Whether RFPL3S...
To improve the understanding of patients with 8p11 myeloproliferative syndrome (EMS) harboring ins(13;8)(q12;p11p23)/ZNF198 -FGFR1.We reported here a EMS case and provided more details on clinical molecular features ins(13;8)(q12;p11p23)/ZNF198-FGFR1，full length ZNF198-FGFR1 was cloned by overlap extension PCR method，and literatures this topic were reviewed.Clinically, ins(13;8)(q12;p11p23)/ZNF198-FGFR1 had distinct hematological characteristics: hyperleukocytosis, myeloid...
Cyclins and related cyclin-dependent kinases play vital roles in regulating the progression cell cycle. Understanding intrinsic mechanisms of cyclins promises knowledge about uncontrolled proliferation prevention cancer cells. Therefore, accurate recognition is important for investigation tumor cells biomedical engineering. This study proposes a novel sequence-based predictor named TYLER (predicT cYcLin-dEpendent pRoteins) addressing long challenge problem predicting proteins (CDPs). We use...
Acute liver injury is a common and serious syndrome caused by multiple factors unclear pathogenesis. If the persists, can lead to cirrhosis failure ultimately results in development of cancer. Emerging evidence has indicated that long noncoding RNAs (lncRNAs) play an important role injury. However, antisense Igf2r RNA (Airn) acute its underlying mechanism remain largely unclear. In this study, we show Airn upregulated tissue primary hepatocytes from mouse model. Consistently, also...
Abstract Some long noncoding RNAs (lncRNAs), which harbor microRNAs in their gene sequence and are also known as microRNA host derived lncRNAs (lnc-MIRHGs), play a dominant role alongside miRNAs, or both perform biological functions synergistically independently. However, only small number of lnc-MIRHGs have been identified. Here, multiple liver injury datasets were analyzed to screen identify the target lncRNA Mir122hg . was mainly enriched tissues with human-mouse homology. In CCl 4...