Mengxia Zhang

ORCID: 0009-0004-9555-4635
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About
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Research Areas
  • RNA modifications and cancer
  • Cancer, Hypoxia, and Metabolism
  • Heme Oxygenase-1 and Carbon Monoxide
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Plant Molecular Biology Research
  • Cancer-related molecular mechanisms research
  • Lung Cancer Treatments and Mutations
  • Head and Neck Cancer Studies
  • Photosynthetic Processes and Mechanisms
  • Glutathione Transferases and Polymorphisms
  • Lung Cancer Research Studies
  • Plant Reproductive Biology
  • Cancer-related gene regulation
  • Psychology of Moral and Emotional Judgment
  • Soil Carbon and Nitrogen Dynamics
  • Plant nutrient uptake and metabolism
  • Cultural Differences and Values
  • Garlic and Onion Studies
  • Plant Gene Expression Analysis
  • Protein Tyrosine Phosphatases
  • Plant biochemistry and biosynthesis
  • Immune cells in cancer
  • MicroRNA in disease regulation
  • Cholangiocarcinoma and Gallbladder Cancer Studies

Dalian Polytechnic University
2019-2025

Hunan University of Traditional Chinese Medicine
2025

Anhui Agricultural University
2023-2024

Institute of Vegetables and Flowers
2022-2024

Chinese Academy of Agricultural Sciences
2018-2024

Institute of Genetics and Developmental Biology
2015-2024

Chinese Academy of Sciences
2015-2024

Hefei Institutes of Physical Science
2023-2024

Tianjin Medical University
2018-2023

Western University
2016-2023

Abstract This paper analyzes the relationship between students' motivations and their intention to participate in study abroad programs using a model based on expectancy theory.We surveyed U.S., Chinese French business students who studied home countries. Results suggest that certain are common among from three We found direction of intent varied countries, nationality moderates all relationships, different levels barriers moderate abroad.

10.1300/j066v18n01_03 article EN Journal of Teaching in International Business 2006-11-01

In flowering plants, sperm cells are delivered to the embryo sac by a pollen tube guided female signals. Both gametic and synergid contribute attraction. Synergids secrete peptide signals that lure tube, while role of is unknown. Previously, we showed CENTRAL CELL GUIDANCE (CCG) essential for attraction in Arabidopsis thaliana, but molecular mechanism unclear. Here, identified CCG BINDING PROTEIN1 (CBP1) demonstrated it interacts with CCG, Mediator subunits, RNA polymerase II (Pol II),...

10.1105/tpc.15.00370 article EN The Plant Cell 2015-10-01

Sunlight radiation is a main environmental factor which affects anthocyanin synthesis. To clarify the regulatory mechanism of sunlight on synthesis in apple peel, bagged apples were exposed to diverse intensities through different shading treatments. Under an increased solar ultraviolet-B (UV-B) light intensity, concentration peels was consistent with Michaelis-Menten equation. lower intensities, diphenyleneiodonium chloride (DPI, inhibitor plasma membrane NAD(P)H oxidase) treatment both...

10.3390/ijms20236060 article EN International Journal of Molecular Sciences 2019-12-01

G-protein coupled receptors (GPCRs) are recognized as attractive targets for drug therapy. However, it remains poorly understood how GPCRs, except a few chemokine receptors, regulate the progression of liver fibrosis. Here, we aimed to reveal role GPR65, proton-sensing receptor, in fibrosis and elucidate underlying mechanism. The expression level GPR65 was evaluated both human mouse fibrotic livers. Furthermore, Gpr65-deficient mice were treated with either bile duct ligation (BDL) 21 d or...

10.1186/s40779-023-00494-4 article EN cc-by Military Medical Research 2023-11-25

Light plays a pivotal role as an environmental factor throughout the entire life cycle of plants, influencing plant growth, development, stress responses, and specialised metabolism. In this study, we identified six growth regulating factors (GRFs) in Catharanthus roseus through genome sequence analysis, notably, two GRFs, CrGRF1 CrGRF4, exhibited responsiveness to light signals. By manipulating expression CrGRF4 C. leaves, both overexpression silencing, observed their capacity enhance...

10.1111/pce.15484 article EN Plant Cell & Environment 2025-03-21

Liver fibrosis leading to cirrhosis is one of the major health burdens worldwide with currently limited therapeutic options available. Long noncoding RNAs (lncRNAs) play important roles in various biological and pathological processes a cell- or tissue-specific manner. However, there still an gap understanding role hepatocyte-specific lncRNAs liver fibrosis. Methods: The expressions lnc-Hser human mice fibrotic livers as well primary hepatocytes (HCs) developing were determined by real-time...

10.7150/thno.36942 article EN cc-by Theranostics 2019-01-01

The xanthophyll cycle, flavonoid metabolism, the antioxidant system and production of active oxygen species were analyzed in peel 'Fuji' apples re-exposed to sunlight after extended periods fruit bagging treatment, resulting different levels photooxidative sunburn. After re-exposing bagged fruits sunlight, photoprotective capacity apple peels both significantly enhanced. As sunburn severity increased, concentration hydrogen peroxide while cycle pool size decreased. For key genes involved...

10.1111/ppl.12272 article EN Physiologia Plantarum 2014-09-03

Rationale: N6-methyladenosine (m 6 A) is involved in critical cancerous processes.Pseudogenes play various roles carcinogenesis and progression.However, the functional of m A-associated pseudogenes head neck squamous cell carcinoma (HNSCC) are largely unknown.Methods: We systematically analyzed mRNA profile 24 A regulators 13931 from The Cancer Genome Atlas HNSCC dataset ultimately identified 10 prognostic pseudogenes, which were validated Gene Expression Omnibus our hospital datasets.Based...

10.7150/thno.76689 article EN cc-by Theranostics 2022-01-01

Triterpenoid saponins, synthesized via the mevalonic acid (MVA) pathway in cytoplasm, provide protection against pathogens and pests plants health benefits for humans. However, mechanisms by which triterpenoid saponins are transported between cellular compartments remain uncharacterized. Here, we characterize a tonoplast localized multidrug toxic compound extrusion transporter, GmMATE100 (encoded

10.1021/acs.jafc.4c01774 article EN Journal of Agricultural and Food Chemistry 2024-04-22

Ossification of the ligamentum flavum (OLF) is a common spinal disorder that causes myelopathy and radiculopathy. Non-coding RNAs (ncRNAs) are involved in numerous pathological processes; however, very few ncRNAs have been identified to be correlated with OLF. Here we compared expression lncRNA, mRNA, circRNA, microRNA OLF tissues from patients healthy volunteers through circRNA microarrays sequencing. A total 2,054 mRNAs, 2,567 lncRNAs, 627 circRNAs, 28 microRNAs (miRNAs) were altered...

10.1016/j.omtn.2018.07.018 article EN cc-by Molecular Therapy — Nucleic Acids 2018-08-07

Significance Double fertilization is a key innovation of flowering plants. The central cell the second female gamete, and its gives rise to endosperm, nurse seed. However, how this specified evolved in angiosperm remains unknown. This study reveals transcriptional repression mechanism specify Arabidopsis provides insight into origination Brassicaceae.

10.1073/pnas.1909465117 article EN Proceedings of the National Academy of Sciences 2020-03-04

Background Radioresistance-induced local failure, which can result in residual or recurrent tumors, remains one of the major causes treatment failure nasopharyngeal carcinoma (NPC). Lipocalin 2 (LCN2) is known to play important roles cancer initiation, progression, and responses. However, its role radioresistance NPC unclear. Methods Microarray data from Gene Expression Omnibus (GEO) was screened for candidate biomarkers relating NPC. The expression LCN2 cell lines verified by quantitative...

10.3389/fonc.2020.605777 article EN cc-by Frontiers in Oncology 2021-02-02

Hypocotyl elongation is dramatically influenced by environmental factors and phytohormones. Indole-3-acetic acid (IAA) plays a prominent role in hypocotyl elongation, whereas abscisic (ABA) regarded as an inhibitor through repressing IAA synthesis signalling. However, the regulatory of ABA local deactivation remains largely uncharacterized. In this study, we confirmed antagonistic interplay during tomato (Solanum lycopersicum) seedlings. We identified oxidase enzyme DIOXYGENASE FOR AUXIN...

10.1111/pce.14491 article EN Plant Cell & Environment 2022-11-12

Despite the substantial economic impact of restaurant industry, large-scale empirical research on survival has been sparse. We investigate whether consumer-posted photos can serve as a leading indicator above and beyond reviews, firm characteristics, competitive landscape, macro conditions. employ machine learning techniques to extract features from 755,758 1,121,069 reviews posted Yelp between 2004 2015 for 17,719 U.S. restaurants. also collect data characteristics (e.g., cuisine type;...

10.2139/ssrn.3108288 article EN SSRN Electronic Journal 2016-01-01

Abstract Grafting onto pumpkin rootstock is widely applied in cucumber production to improve growth and yield, as well overcome soil‐borne diseases enhance resistance abiotic stresses. In this study, we constructed the cucumber‐pumpkin heterografts with one‐cotyledon grafting method, examined effects of heterografting on biomass allocation sugar partitioning, self‐grafts used control. Compared self‐grafts, promoted photosynthesis scion, led higher sucrose contents 1st true leaf (source)...

10.1111/ppl.14232 article EN Physiologia Plantarum 2024-03-01

The endosperm in cereal grains is instrumental determining grain yield and seed quality, as it controls starch storage protein (SSP) production. In this study, we identified a specific nuclear factor-Y (NF-Y) trimeric complex wheat (Triticum aestivum L.), consisting of TaNF-YA3-D, TaNF-YB7-B, TaNF-YC6-B, exhibiting robust expression within the during filling. Knockdown either TaNF-YA3 or TaNF-YC6 led to reduced but increased gluten levels. TaNF-Y indirectly boosted biosynthesis genes by...

10.1093/plcell/koae256 article EN The Plant Cell 2024-09-18

The huge amount of urea applied has necessitated best-developed practices to slow down the release nitrogen (N) fertilizer while minimizing nitrate loss. However, impact nitrification inhibitors on mineral-N turnover and associated microbial mechanisms at different stages remains unknown. A 60-day incubation experiment was conducted with four treatments: no (CK), (U), copper pyrazole (UC), coated (SUC), evaluate changes about soil ammonia N ( <mml:math...

10.3389/fmicb.2024.1433816 article EN cc-by Frontiers in Microbiology 2024-10-01

Purpose The purpose of this paper is to investigate how cultural tightness may influence consumers’ attitudes toward insurance services and occurrence fraud. Design/methodology/approach Drawing on Gelfand et al.’s (2011) theory tight loose cultures, the authors theorize that perceived wrongness fraud, fraud risk being caught depend tightness. Using field data from a global European social survey (ESS), these differences across two fairly different countries – Norway (i.e. culture) Ukraine...

10.1108/ijqss-02-2017-0016 article EN International Journal of Quality and Service Sciences 2018-04-18

Adventitious root (AR) formation is a critical process in cutting propagation of horticultural plants. Brassinosteroids (BRs) have been shown to regulate AR several plant species; however, little known about their exact effects on pepper formation, and the downstream signaling BRs also remains elusive. In this study, we showed that treatment 24-Epibrassinolide (EBL, an active BR) at concentrations 20-100 nM promoted (Capsicum annuum). Furthermore, investigated roles apoplastic reactive...

10.3390/antiox12071451 article EN cc-by Antioxidants 2023-07-19
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