A5009117507- Hormonal Regulation and Hypertension
- Reproductive System and Pregnancy
- Plant biochemistry and biosynthesis
- Renal Diseases and Glomerulopathies
- Ion Transport and Channel Regulation
- Electrolyte and hormonal disorders
- Photosynthetic Processes and Mechanisms
- Neonatal Health and Biochemistry
- Apelin-related biomedical research
- Sulfur Compounds in Biology
- Transgenic Plants and Applications
- Hydrogen's biological and therapeutic effects
- Adrenal Hormones and Disorders
- PI3K/AKT/mTOR signaling in cancer
- Birth, Development, and Health
- Intraocular Surgery and Lenses
- Retinopathy of Prematurity Studies
- Animal Genetics and Reproduction
- Cellular transport and secretion
- Calcium signaling and nucleotide metabolism
- Atherosclerosis and Cardiovascular Diseases
- Regulation of Appetite and Obesity
- Renal and Vascular Pathologies
- Adrenal and Paraganglionic Tumors
- Ophthalmology and Eye Disorders
Dalian Polytechnic University
2023-2025
Shenyang Agricultural University
2024-2025
Zhongnan Hospital of Wuhan University
2025
Wuhan University
2025
University of Nebraska Medical Center
2011-2018
University of Virginia
2014
Affiliated Eye Hospital of Wenzhou Medical College
2014
Wenzhou Medical University
2014
Vanderbilt University
2008
Universität Hamburg
2002
The serum- and glucocorticoid-regulated kinase (sgk1) is induced by mineralocorticoids and, in turn, upregulates heterologously expressed renal epithelial Na+ channel (ENaC) activity Xenopus oocytes. Accordingly, Sgk1 considered to mediate the mineralocorticoid stimulation of ENaC antinatriuresis. Here we show that at standard NaCl intake, water electrolyte excretion indistinguishable sgk1-knockout (sgk1–/–) mice wild-type (sgk1+/+) mice. In contrast, dietary restriction reveals an impaired...
The serum- and glucocorticoid-regulated kinase (sgk1) is induced by mineralocorticoids and, in turn, upregulates heterologously expressed renal epithelial Na+ channel (ENaC) activity Xenopus oocytes. Accordingly, Sgk1 considered to mediate the mineralocorticoid stimulation of ENaC antinatriuresis. Here we show that at standard NaCl intake, water electrolyte excretion indistinguishable sgk1-knockout (sgk1–/–) mice wild-type (sgk1+/+) mice. In contrast, dietary restriction reveals an impaired...
OBJECTIVE—Elevated triglyceride (TG) is the major plasma lipid abnormality in obese and diabetic patients contributes to cardiovascular morbidity these disorders. We sought identify novel mechanisms leading hypertriglyceridemia. Resistance negative feedback signals from adipose tissue key central nervous system (CNS) energy homeostatic circuits development of obesity. Because triglycerides both represent largest depot body are elevated obesity diabetes, we hypothesized that same neural...
Nephritis is one of the major complications systemic lupus erythematosus. While glucocorticoids (GCs) are frequently used as first-line treatment for nephritis (LN), long-term GC usage often complicated by severe adverse effects. To address this challenge, we have developed a polyethylene glycol-based macromolecular prodrug (ZSJ-0228) dexamethasone, which self-assembles into micelles in aqueous media. When compared to dose equivalent daily dexamethasone 21-phosphate disodium (Dex) treatment,...
Primary aldosteronism lateralization is critical for the treatment option. This study evaluated preoperative localization diagnostic efficiency of 68Ga-pentixafor positron emission tomography/computed tomography imaging, targeting C-X-C chemokine receptor type 4 in patients with primary and comparing adrenal venous sampling, current gold standard lateralization. Fifty underwent sampling imaging region separately. Patients determined by or adrenalectomy, followed pathologic diagnoses...
Light plays a pivotal role as an environmental factor throughout the entire life cycle of plants, influencing plant growth, development, stress responses, and specialised metabolism. In this study, we identified six growth regulating factors (GRFs) in Catharanthus roseus through genome sequence analysis, notably, two GRFs, CrGRF1 CrGRF4, exhibited responsiveness to light signals. By manipulating expression CrGRF4 C. leaves, both overexpression silencing, observed their capacity enhance...
Triterpenoid saponins, synthesized via the mevalonic acid (MVA) pathway in cytoplasm, provide protection against pathogens and pests plants health benefits for humans. However, mechanisms by which triterpenoid saponins are transported between cellular compartments remain uncharacterized. Here, we characterize a tonoplast localized multidrug toxic compound extrusion transporter, GmMATE100 (encoded
To investigate the effects of transient high perfusion pressure on retinal vessel diameter and ganglion cells.The animals were divided into four groups according to different infusion time (60 mm Hg-3min, 60 Hg-5min, 100 Hg-5min). Each group consisted six rabbits. The left eye was used as experimental right a control. Retinal vascular diameters evaluated before, during infusion, immediately after 5min, 10min 30min based fundus photographs. Blood monitored infusion. eyes removed 24h. Damage...
Many monoterpenoid indole alkaloids (MIAs) produced in Catharanthus roseus have demonstrated biological activities and clinical potential. However, their complex biosynthesis pathway plants leads to low accumulation, limiting therapeutic applications. Efforts elucidate the MIA biosynthetic regulatory mechanism focused on improving accumulation levels. Previous studies revealed that jasmonic acid (JA), an important plant hormone, effectively promotes by inducing expression of transport genes....
ABSTRACT Catharanthus roseus is a highly relevant model for investigating plant defense mechanisms and the biosynthesis of therapeutically valuable compounds, including terpenoid indole alkaloids (TIAs). It has been demonstrated that beneficial microbial interactions can regulate TIA in C. , highlighting need to fully comprehend molecular involved efficiently implement eco‐friendly strategies. This study explores effects novel strain, Y503, identified as Sphingomonas sp., on production...
Renal vascular development is dependent on the participation of renin precursor cells, which localize to areas new vessel formation and differentiate into smooth muscle cells (SMCs), mesangial juxtaglomerular (JG) cells. However, mechanisms that enforce this particular fate remain unclear. During embryogenesis, express a significant number angiogenic factors including Notch signaling ligand Jagged1. We therefore hypothesized Jagged1 necessary for precursors various mural renal arterioles...
The pulsatile uterine secretion of prostaglandin F2 alpha (PGF) triggers the regression corpus luteum (CL). Research from many laboratories has identified early intracellular signaling events initiated by PGF (for example, activation phospholipases, increased calcium, and protein kinases) their involvement in induction a response genes like FOS, JUN, growth 1 (EGR1). Recent studies have used microarray analysis to examine global patterns gene expression approximately 24 hours following...