A5014788412- Systemic Lupus Erythematosus Research
- Rheumatoid Arthritis Research and Therapies
- Cancer Immunotherapy and Biomarkers
- Inflammatory Myopathies and Dermatomyositis
- Atherosclerosis and Cardiovascular Diseases
- T-cell and B-cell Immunology
- Spinal Hematomas and Complications
- Surgical site infection prevention
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Surgical Sutures and Adhesives
- Bone Metabolism and Diseases
- Cancer-related molecular mechanisms research
- Hip and Femur Fractures
- Galectins and Cancer Biology
- Lung Cancer Diagnosis and Treatment
- Spinal Fractures and Fixation Techniques
- Bone fractures and treatments
- Anesthesia and Pain Management
- Head and Neck Surgical Oncology
- Autoimmune and Inflammatory Disorders Research
- Cytokine Signaling Pathways and Interactions
- Wound Healing and Treatments
- Bone and Joint Diseases
- Monoclonal and Polyclonal Antibodies Research
People 's Hospital of Jilin Province
2024
First Affiliated Hospital of Xi'an Jiaotong University
2010-2024
Jishou University
2017-2024
Sichuan University
2015-2024
Hunan University
2023-2024
Xi'an Jiaotong University
2010-2022
Huaian First People’s Hospital
2009-2022
Center for Rheumatology
2022
Institute of Vegetables and Flowers
2022
Chinese Academy of Agricultural Sciences
2022
Human carboxylesterase 2 (CES2), one of the most abundant hydrolases distributed in small intestine, has been validated as a key therapeutic target to ameliorate intestinal toxicity caused by irinotecan. This study aims discover efficacious CES2 inhibitors from natural products and characterize inhibition potentials inhibitory mechanisms newly identified inhibitors. Following high-throughput screening evaluation potency more than 100 against CES2, it was found that biflavones isolated Ginkgo...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by chronic inflammation. Different studies have shown decreased bone mineral density (BMD) in patients with SLE. The objective of this study was to investigate the prevalence and possible risk factors low BMD untreated female SLE Chinese population. A total 119 were included. measured at lumbar spine hip dual-energy X-ray absorptiometry. associations between demographic variables, clinical metabolism variables...
Objective: This study aims to investigate the regulatory mechanism of 1,25-(OH)2D3 on proliferation fibroblast-like synoviocytes (FLS) and expressions pro-inflammatory cytokines in rheumatoid arthritis (RA) rats via microRNA-22 (miR-22). Methods: A rat model RA was established with a subcutaneous injection type II collagen. After treated different concentrations FLS estimated by MTT method, optimal concentration selected for further experiments. Cell detected MTT. cycle apoptosis were...
Background:The use of immunotherapy is progressively expanding for the treatment lung cancer, either alone or in combination with radiotherapy.However, treatment-related adverse events, especially pneumonia, significantly limit drug's effectiveness treating cancer.The occurrence immunotherapy, and pulmonary radiotherapy can all contribute to imbalance microbiota, rendering lungs more susceptible inflammatory reactions.Methods: Mouse models transplantation tumor were treated PD-1 monoclonal...
This study examines tuberculosis (TB) incidence among students in Jilin Province, China, focusing on spatial, temporal, and demographic dynamics areas of social inequality. Variation rate TB was analyzed using the joinpoint regression method. Spatial analyses techniques included global local Moran indices Getis-Ord Gi* analysis. Demographic changes new cases were descriptively, Geodetector method measured influence risk factors student incidence. The analysis revealed a declining trend...
Hypocotyl elongation is dramatically influenced by environmental factors and phytohormones. Indole-3-acetic acid (IAA) plays a prominent role in hypocotyl elongation, whereas abscisic (ABA) regarded as an inhibitor through repressing IAA synthesis signalling. However, the regulatory of ABA local deactivation remains largely uncharacterized. In this study, we confirmed antagonistic interplay during tomato (Solanum lycopersicum) seedlings. We identified oxidase enzyme DIOXYGENASE FOR AUXIN...
Mesenchymal stem cells (MSCs) are considered the best candidate in therapy due to their multipotent differentiation ability, low expression of co-stimulatory molecules (CD80, CD86, CD34 and HLA-II) immunosuppression effects on vivo immune responses. MSCs were now widely used clinical trials but received no encourage results. The major problem was fate engrafted could not be defined. Some studies indicated that induce response result damage rejection MSCs. As toll like receptors (TLRs)...
Fibrous dysplasia associated with aneurysmal bone cyst (ABC)-like changes in the right proximal femur has a low incidence. It is considered more difficult to make early diagnosis than for single fibrous dysplasia.A 14-year-old woman was admitted because of persistent pain hip and abnormal gait over previous 2 mo. She had no history present or past illness. Preoperative photography, enhanced computed tomography, magnetic resonance imaging showed ground-glass appearance cortical scalloping...
To investigate the mechanism underlying systemic lupus erythematosus (SLE)-related bone loss by evaluating mineral density (BMD) and turnover markers (BTMs) in premenopausal patients with new-onset SLE without any treatment.BMD BTMs of 106 64 gender-, age- body mass index (BMI)-matched healthy controls were analyzed. BMD was determined using dual energy X-ray absorptiometry (DXA). Serum measured.Hip lumbar spine significantly decreased compared controls. Higher rate osteoporosis observed...
Background In recent years, severe pain after perianal surgery has seriously affected the prognosis of hospitalized patients. How to maximize improvement postoperative and perioperative comfort becomes particularly important. Methods This study was a double-blind randomized controlled trial (Registration No.: ChiCTR2100048760, Registration Date: 16 July 2021, Link: www.chictr.org.cn/showproj.html?proj=130226 ), patients were randomly divided into two groups: one group underwent 20 mL...