A5029946717- Osteoarthritis Treatment and Mechanisms
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Bone and Joint Diseases
- Vitamin D Research Studies
- Musculoskeletal synovial abnormalities and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- Hip disorders and treatments
- Musculoskeletal pain and rehabilitation
- Systemic Lupus Erythematosus Research
- Adipokines, Inflammation, and Metabolic Diseases
- Autoimmune and Inflammatory Disorders Research
- Neuropeptides and Animal Physiology
- Bone health and treatments
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Orthopedic Infections and Treatments
- Chemokine receptors and signaling
- Receptor Mechanisms and Signaling
- Cytokine Signaling Pathways and Interactions
University of Tasmania
2016-2025
Southern Medical University
2016-2025
Zhujiang Hospital
2018-2025
Guangzhou First People's Hospital
2021-2025
Guangzhou Medical University
2021-2025
South China University of Technology
2021-2025
Ningbo University Affiliated Hospital
2025
Anhui Medical University
2015-2025
Wuhan University of Technology
2025
Ji Hua Laboratory
2025
<b>Objectives:</b> To evaluate further in a phase III, double blind trial the efficacy of infliximab patients with active psoriatic arthritis (PsA), as observed smaller IMPACT trial. <b>Methods:</b> 200 PsA unresponsive to previous treatment were randomised infusions 5 mg/kg or placebo at weeks 0, 2, 6, 14, and 22. Patients inadequate response entered early escape week 16. The primary measure clinical was ACR20. Other measures included Psoriatic Arthritis Response Criteria (PsARC), Psoriasis...
IL-1, IL-6, and TNF-alpha play an important role in the pathogenesis of osteoporosis animals; however, evidence that these a similar bone loss human studies is limited.Our objective was to determine associations between serum markers inflammation changes mineral density (BMD) urinary pyridinoline (PYR) creatinine (Cr) ratio over 2.9 yr older adults.A total 168 randomly selected subjects (mean 63 yr, range 52-78, 48% female) studied. BMD measured by dual-energy x-ray absorptiometry at...
<h3>Objective</h3> To determine the association between inflammatory markers and change in knee pain over 5 years. <h3>Methods</h3> A total of 149 randomly selected subjects (mean 63 years, range 52–78; 46% female) was studied. Serum levels high sensitivity C-reactive protein (hs-CRP), tumour necrosis factor alpha (TNF–α) interleukin (IL)-6 were measured at baseline 2.7 years later. Knee recorded using Western Ontario McMasters osteoarthritis index questionnaire radiographic both knees...
<h3>Importance</h3> Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current trial evidence contradictory. <h3>Objective</h3> To compare the effects of vs placebo on pain and cartilage volume in patients symptomatic osteoarthritis low levels. <h3>Design, Setting, Participants</h3> A multicenter randomized, double-blind, placebo-controlled clinical Tasmania Victoria, Australia. Participants 25-hydroxyvitamin (12.5-60 nmol/L)...
Osteoarthritis (OA), a disease with whole-joint damage and dysfunction, is the leading cause of disability worldwide. The progressive loss hyaline cartilage extracellular matrix (ECM) considered as its hallmark, but exact pathogenesis needs to be further clarified. MicroRNA(miRNA) contributes OA pathology may help identify novel biomarkers therapies against OA. Here we identified miR-214-3p an important regulator OA.qRT-PCR in situ hybridization were used detect expression level miR-214-3p....
The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint homeostasis the progression of osteoarthritis (OA). cellular transcriptional mechanisms regulating function these specialized tissues under healthy diseased conditions are largely unknown. Here, single-cell single-nuclei RNA sequencing human IPFP synovial were performed to elucidate composition profile. Computational trajectory analysis revealed that dipeptidyl peptidase 4 + mesenchymal cells as a...
Recent interest has focused on the potential role of amylin in pathogenesis non-insulin-dependent diabetes mellitus (NIDDM). This 37-amino acid peptide is found extracellular amyloid deposits ∼50% pancreatic islets patients with NIDDM and been shown to inhibit skeletal muscle glycogen synthesis vitro. Immunocytochemical studies have colocalized insulin within β-cell secretory granules nondiabetic humans, provoking following questions. Is cosecreted insulin? Are circulating concentrations...
Abstract Objective The significance of asymptomatic knee cartilage defects in healthy individuals is not known. aim this study was to examine the association between and volume both cross‐sectionally longitudinally healthy, middle‐age adults. Methods Eighty‐six men women (mean ± SD age 53.8 8.8 years) underwent T1‐weighted fat‐suppressed magnetic resonance imaging their dominant knees at baseline 2‐year followup visit. Knee measured. Cartilage were scored according a grading system (0–4) as...
Summary Objective Low 25‐hydroxyvitamin D (25OHD) levels may be associated with both sarcopenia (the age‐related decline in muscle mass and function) low physical activity (PA). Our objective was to describe prospective associations between 25OHD, parameters, PA community‐dwelling older adults. Design Prospective, population‐based study a mean follow‐up of 2·6 ± 0·4 years. Patients Six hundred eighty‐six adults (49% women; SD 62 7 years old). Measurements Appendicular lean percentage (%ALM)...
Tyr-dTrp-Gly-Phe-Met-NH2 is a unique synthetic Met5-enkephalin peptide analog that at concentrations of 1–100 μg/ml incubation medium acts directly on the pituitary rats in vitro to release GH specifically but not LH, FSH, TSH, PRL, or ACTH. Structure-activity studies this pentapeptide emphasize prime importance an aromatic amino acid residue 2 position for GH-releasing activity. Both Tyr-dTrp-Gly-Phe-Met-NH2, and Tyr-dPhe-Gly-Phe-Met-NH2 released vitro, while large seven enkephalin analogs,...
<h3>Background</h3> Knee cartilage defects may play an important role in early osteoarthritis, but little is known about their natural history. <h3>Methods</h3> defect score (range, 0-4), volume, and bone surface area were determined using T1-weighted fat-saturated magnetic resonance imaging 325 subjects (mean age, 45 years) at baseline 2 years later. <h3>Results</h3> Thirty-three percent of the had a worsening (≥1-point increase) 37% improvement decrease) any knee compartment during 2.3...
Abstract Objective To determine the associations between serum levels of vitamin D, sunlight exposure, and knee cartilage loss cross‐sectionally longitudinally in older adults. Methods A total 880 randomly selected subjects (mean age 61 years [range 51–79 years], 50% women) were studied at baseline, 353 these 2.9 later. Serum 25‐hydroxyvitamin D (25[OH]D) assessed by radioimmunoassay, exposure was questionnaire. T1‐weighted fat‐suppressed magnetic resonance imaging (MRI) right performed to...
Abstract Objective To describe the association between chondral defects, bone marrow lesions, knee and hip radiographic osteoarthritis (OA), pain. Methods Knee pain was assessed by Western Ontario McMaster Universities Osteoarthritis Index. T1‐ T2‐weighted fat saturation magnetic resonance imaging performed on right to assess defects subchondral lesions. Radiography scored for OA. Body mass index (BMI) extension strength were measured. Results A total of 500 randomly selected men women...
The action of (Gln4)-neurotensin was studied on the spontaneous motor activity in isolated canine fundic, antral and intestinal pouches. All pouches had been prepared more than 6 months prior to experiments. Spontaneous recorded for at least 1 h before Gln4)-neurotensin infused i.v. 30 min doses ranging between 6.3 100 ng X kg-1 min-1. In vagally denervated fundic inhibted above 25 innervated were sentitive (Gln4)-neurotensin. Thus inhibition induced by as low effect inconsistent. Inhibition...