A5074247805- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Lower Extremity Biomechanics and Pathologies
- Rheumatoid Arthritis Research and Therapies
- Inflammatory mediators and NSAID effects
- Vitamin D Research Studies
- Musculoskeletal synovial abnormalities and treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Bone and Joint Diseases
- Bone health and treatments
- Bone health and osteoporosis research
- Cancer-related molecular mechanisms research
- Perfectionism, Procrastination, Anxiety Studies
- Musculoskeletal pain and rehabilitation
- Chronic Disease Management Strategies
- Shoulder Injury and Treatment
- Infrared Thermography in Medicine
- Genetic Associations and Epidemiology
- Metabolism, Diabetes, and Cancer
- Autoimmune and Inflammatory Disorders Research
- Bone Metabolism and Diseases
- Parkinson's Disease Mechanisms and Treatments
- Extracellular vesicles in disease
- Liver Disease Diagnosis and Treatment
Southern Medical University
2018-2025
Zhujiang Hospital
2018-2025
The University of Sydney
2024-2025
Royal North Shore Hospital
2024
China University of Mining and Technology
2023-2024
University of Tasmania
2015-2023
Massachusetts General Hospital
2021-2023
Clinical Research Management
2023
Harvard University
2023
Tongji University
2022
<h3>Importance</h3> Observational studies suggest that vitamin D supplementation is associated with benefits for knee osteoarthritis, but current trial evidence contradictory. <h3>Objective</h3> To compare the effects of vs placebo on pain and cartilage volume in patients symptomatic osteoarthritis low levels. <h3>Design, Setting, Participants</h3> A multicenter randomized, double-blind, placebo-controlled clinical Tasmania Victoria, Australia. Participants 25-hydroxyvitamin (12.5-60 nmol/L)...
Osteoarthritis (OA), a disease with whole-joint damage and dysfunction, is the leading cause of disability worldwide. The progressive loss hyaline cartilage extracellular matrix (ECM) considered as its hallmark, but exact pathogenesis needs to be further clarified. MicroRNA(miRNA) contributes OA pathology may help identify novel biomarkers therapies against OA. Here we identified miR-214-3p an important regulator OA.qRT-PCR in situ hybridization were used detect expression level miR-214-3p....
The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint homeostasis the progression of osteoarthritis (OA). cellular transcriptional mechanisms regulating function these specialized tissues under healthy diseased conditions are largely unknown. Here, single-cell single-nuclei RNA sequencing human IPFP synovial were performed to elucidate composition profile. Computational trajectory analysis revealed that dipeptidyl peptidase 4 + mesenchymal cells as a...
Abstract Background To describe demographic and clinical factors associated with the presence incidence of depression explore temporal relationship between joint symptoms in patients symptomatic knee osteoarthritis (OA). Methods Three hundred ninety-seven participants were selected from a randomized controlled trial people OA vitamin D deficiency (age 63.3 ± 7.1 year, 48.6% female). Depression severity assessed using patient health questionnaire (PHQ-9) Western Ontario McMaster Universities...
Background Infrapatellar fat pad (IPFP) quality has been implicated as a marker for predicting knee osteoarthritis (KOA); however, no valid quantification subtle IPFP abnormalities established. Purpose To investigate whether MRI-based three-dimensional texture analysis of could help predict incident radiographic KOA. Materials and Methods In this prospective nested case-control study, 690 participants whose knees were at risk KOA included from the Pivotal Osteoarthritis Initiative MRI...
This study aims to identify circulating proteins that are causally associated with osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical framework.Large-scale two-sample MR was employed estimate the effects of thousands plasma on 12 OA-related traits. Additional analyses including Bayesian colocalisation, Steiger filtering analysis, assessment protein-altering variants and mapping expression quantitative trait loci protein were performed investigate...
To describe the associations between infrapatellar fat pad (IPFP) signal intensity alteration at baseline and knee symptoms structural changes in older adults.A total of 874 subjects (mean 62.1 years, 50.1% female) selected randomly from local community were studied 770 followed up (only 357 had MRI follow-up) over 2.6 years. T1-weighted or T2-weighted suppressed was used to assess IPFP (0-3), cartilage volume, defects bone marrow lesions (BMLs) years later. Knee pain assessed by...
Abstract Objective To investigate the therapeutic effect and mechanism of metformin on knee OA in normal diet (ND) mice or high-fat (HFD)-induced obese mice. Methods Destabilization medial meniscus surgery was performed ND HFD mice, administrated drinking water not. The changes joint structure, infiltration polarization synovial macrophages circulating local levels leptin adiponectin were evaluated. In vitro, effects chondrocytes macrophages, conditioned mediums derived from mouse abdominal...
Accurately predicting knee osteoarthritis (KOA) is essential for early detection and personalized treatment. We aimed to develop test a magnetic resonance imaging (MRI)-based joint space (JS) radiomic model (RM) predict radiographic KOA incidence through neural networks by integrating meniscus femorotibial cartilage features.
Osteoarthritis is a prevalent musculoskeletal condition, but the role of specific serum biomarkers, such as calcium, vitamin D, and C-reactive protein (CRP), in predicting mortality among individuals with osteoarthritis remains unclear. This observational study analyzed longitudinal data from over 500,000 participants UK Biobank, identifying those using ICD-9/10 codes or self-reported history. We performed multivariable cox-regression flexible parametric survival model (FPSM) for analysis,...
Objectives To develop and validate a nomogram to detect improved knee pain in osteoarthritis (OA) by integrating magnetic resonance imaging (MRI) radiomics signature of subchondral bone clinical characteristics. Methods Participants were selected from the Vitamin D Effects on Osteoarthritis (VIDEO) study. The primary outcome was 20% improvement score over 2 years participants administrated either vitamin or placebo. Radiomics features characteristics 216 extracted analyzed. randomly split...
Inflammatory cytokine–induced activation of nuclear factor κB (NF-κB) signaling plays a critical role in the pathogenesis osteoarthritis (OA). We identified PILA as long noncoding RNA (lncRNA) that enhances NF-κB and OA. The abundance was increased damaged cartilage from patients with OA human articular chondrocytes stimulated proinflammatory cytokine tumor necrosis (TNF). Knockdown inhibited TNF-induced signaling, extracellular matrix catabolism, apoptosis chondrocytes, whereas ectopic...
This study aimed to estimate the temporal trend of osteoarthritis (OA) burden in China by age, sex, and joint sites from 1990 2019 predict long-term over next 25 years.