A5021208951- Hepatitis C virus research
- Smoking Behavior and Cessation
- Liver Disease Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Congenital Heart Disease Studies
- Hepatitis B Virus Studies
- Liver Disease and Transplantation
- Health disparities and outcomes
- Knee injuries and reconstruction techniques
- Behavioral Health and Interventions
- HIV/AIDS drug development and treatment
- Antioxidant Activity and Oxidative Stress
- Racial and Ethnic Identity Research
- Nutritional Studies and Diet
- Neuroscience and Neuropharmacology Research
- Nuts composition and effects
- Air Quality and Health Impacts
- DNA Repair Mechanisms
- Estrogen and related hormone effects
- Cancer-related molecular mechanisms research
- Inflammatory mediators and NSAID effects
- Horticultural and Viticultural Research
- Obesity, Physical Activity, Diet
- Angiogenesis and VEGF in Cancer
- Hepatitis Viruses Studies and Epidemiology
Southern Medical University
2020-2025
Zhujiang Hospital
2020-2025
Weifang People's Hospital
2025
Kanion Pharmaceutical (China)
2025
Michael E. DeBakey VA Medical Center
2014-2024
Center for Innovation
2014-2024
University of Jinan
2024
Nanjing General Hospital of Nanjing Military Command
2024
Baylor College of Medicine
2006-2024
Shandong University of Political Science and Law
2023
The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct-acting antivirals (DAA) is unclear. Our aim was to examine the and determinants HCC in patients cured DAA.We conducted a retrospective cohort study hepatitis C virus who were treated DAA any 129 Veterans Health Administration hospitals between January 1, 2015 December 31, 2015. We calculated annual incidence rates by SVR. used Cox regression models compare vs those without SVR identify factors...
Sustained virologic response (SVR) after direct acting antiviral agents (DAAs) holds promise for reducing hepatocellular cancer (HCC). DAAs have recently been available long enough to estimate the long‐term risk. We conducted a retrospective cohort study of hepatitis C virus (HCV) patients who achieved SVR with from 129 Veterans Health Administration hospitals between January 1, 2015, and December 31, follow‐up through September 30, 2018. calculated overall quarterly HCC incidence rates....
Several national health care-based smoking cessation initiatives have been recommended to facilitate the delivery of evidence-based treatments, such as quitline (telephone-based tobacco services) assistance. The most notable examples are 5 As (Ask, Advise, Assess, Assist, Arrange) and Ask. Advise. Refer. (AAR) programs. Unfortunately, rates primary care referrals quitlines low, referred smokers fail call for assistance.To evaluate a new approach--Ask-Advise-Connect (AAC)--designed address...
Children with congenital heart disease (CHD) are at risk for developmental delay (DD). Changes in cognitive, language, and motor skills early childhood have not been described. We report the results of a structured approach using longitudinal testing to identify problems ensure intervention accordance published guidelines.Bayley Scales Infant Development, Third Edition, were used assess 99 children CHD. Subjects evaluated 3 6 times first years life. DD was defined as scores >1 SD below...
Osteoarthritis (OA), a disease with whole-joint damage and dysfunction, is the leading cause of disability worldwide. The progressive loss hyaline cartilage extracellular matrix (ECM) considered as its hallmark, but exact pathogenesis needs to be further clarified. MicroRNA(miRNA) contributes OA pathology may help identify novel biomarkers therapies against OA. Here we identified miR-214-3p an important regulator OA.qRT-PCR in situ hybridization were used detect expression level miR-214-3p....
The infrapatellar fat pad (IPFP) and synovium play essential roles in maintaining knee joint homeostasis the progression of osteoarthritis (OA). cellular transcriptional mechanisms regulating function these specialized tissues under healthy diseased conditions are largely unknown. Here, single-cell single-nuclei RNA sequencing human IPFP synovial were performed to elucidate composition profile. Computational trajectory analysis revealed that dipeptidyl peptidase 4 + mesenchymal cells as a...
Angiostatin is a potent angiogenesis inhibitor which has been identified as an internal fragment of plasminogen that includes its first four kringle modules. We have recently demonstrated the anti-endothelial cell proliferative activity angiostatin also displayed by three structures and marginally so 4 (Cao, Y., Ji, R.-W., Davidson, D., Schaller, J., Marti, Sohndel, S., McCance, S. G., O'Reilly, M. Llinás, M., Folkman, J. (1996) <i>J. Biol. Chem.</i> 271, 29461–29467). now report 5 human...
We investigated differences in smoking behaviors between US-and Mexican-born ever smokers and examined the influence of US culture on initiation.Participants were 5030 adults Mexican descent enrolled an ongoing population-based cohort Houston, Tex.More men than women reported current smoking; rates among US-born higher those women. Smoking earlier published Hispanics non-Hispanic Whites but similar to African Americans. Current lower for Hispanics, Whites, Older age, male gender, a level...
We examined the influence of tobacco outlet density and residential proximity to outlets on continuous smoking abstinence 6 months after a quit attempt.
Abstract Objective: To evaluate the association between birthplace (Mexico or U.S.) and obesity in men women to analyze relationship duration of U.S. residency prevalence Mexican immigrants. Research Methods Procedures: We used cross‐sectional data from 7503 adults descent residing Harris County, TX, relationships among BMI, birthplace, years U.S., controlling for demographic characteristics, physical activity level, acculturation level. Results: U.S.‐born had an increased risk (between 34%...
Abstract It is generally accepted that glioma develops through accumulation of genetic alterations. We hypothesized polymorphisms candidate genes involved in the DNA repair pathways may contribute to susceptibility glioma. To address this possibility, we conducted a study on 373 Caucasian cases and 365 cancer-free controls assess associations between risk 18 functional single-nucleotide genes. evaluated potential gene-gene gene-environment interactions using multianalytic strategy combining...
To compare the efficacy of Mindfulness-Based Addiction Treatment (MBAT) to a Cognitive Behavioral (CBT) that matched MBAT on treatment contact time, and Usual Care (UC) condition comprised brief individual counseling.Participants (N = 412) were 48.2% African American, 41.5% non-Latino White, 5.4% Latino, 4.9% other, 57.6% reported total annual household income < $30,000. The majority participants female (54.9%). Mean cigarettes per day was 19.9 (SD 10.1). Following baseline visit, randomized...
Paneth cell dysfunction has been implicated in a subset of Crohn's disease (CD) patients. We previously stratified clinical outcomes CD patients by using phenotypes, which we defined the intracellular distribution antimicrobial proteins. Animal studies suggest that cells shape intestinal microbiome. However, it is unclear whether phenotypes alter microbiome complexity subjects. Therefore, analyzed correlation with mucosal composition and ileal RNA expression pediatric noninflammatory bowel...
Children with congenital heart disease are at risk for developmental delay. This study sought to identify early factors abnormal trajectories in children disease.Children high delay, without known genetic abnormality, and ≥3 assessments by the use of Bayley Scales Infant Toddler Development, Third Edition, were studied. Logistic regression was used assess impact patient clinical on cognitive, language, motor score trajectories; classified as: average or improved if all scores ≥85 (<1...
Abstract DNA repair genes play a major role in maintaining genomic stability through different pathways that are mediated by cell cycle control such as p53. We found previously glioma patients were susceptible to γ-ray-induced chromosomal breaks, which may be influenced genetic variation involved strand XRCC1 single-strand break repair, XRCC3 and RAD51 homologous recombination XRCC7 nonhomologous end joining double-strand repair. Therefore, we tested the hypothesis polymorphisms XRCC1,...
Preventing readmission has been the focus of numerous quality improvement efforts across many conditions. Early outpatient follow-up proposed as best mechanism for reducing readmissions. The extent to which early averts or improves outcomes in cirrhosis is not known. We evaluated relationship between and short-term mortality patients with cirrhosis. conducted a retrospective cohort study who were hospitalized liver-related diagnosis discharged home from 122 Veterans Administration hospitals...
Direct-acting anti-virals (DAA) are safe, effective treatment of hepatitis C virus (HCV). Suboptimal linkage to specialists and access DAAs the leading barriers treatment; however, data limited.To determine predictors follow-up, receipt DAAs, reasons for lack thereof.We used clinical from retrospective cohort HCV-infected patients with previously established HCV care in US Department Veterans Affairs examine follow-up clinics DAA (during 12/1/2013-4/30/2015). We then conducted a structured...
Direct acting antiviral agents (DAA) are highly effective yet expensive. Disparities by race and/or gender often exist in the use of costly medical advances as they become available.