A5100616014- Inflammatory Biomarkers in Disease Prognosis
- Mesenchymal stem cell research
- Parkinson's Disease Mechanisms and Treatments
- Neonatal Respiratory Health Research
- Neurological disorders and treatments
- Immune Response and Inflammation
- Botulinum Toxin and Related Neurological Disorders
- Colorectal and Anal Carcinomas
- Lung Cancer Research Studies
- Folate and B Vitamins Research
- Voice and Speech Disorders
- Cholesterol and Lipid Metabolism
- MRI in cancer diagnosis
- Venous Thromboembolism Diagnosis and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiac Fibrosis and Remodeling
- Natural Antidiabetic Agents Studies
- Biomarkers in Disease Mechanisms
- Immune cells in cancer
- Cellular Mechanics and Interactions
- Cardiac Valve Diseases and Treatments
- Bone and Joint Diseases
- Cancer Treatment and Pharmacology
- Occupational and environmental lung diseases
Capital Medical University
2024
Shanghai Ninth People's Hospital
2024
Huazhong University of Science and Technology
2024
Tongji Hospital
2024
Henan University
2024
Zhejiang Hospital
2022-2024
Beijing Tian Tan Hospital
2024
Xijing University
2023
Longhua Hospital Shanghai University of Traditional Chinese Medicine
2021
Shanghai University of Traditional Chinese Medicine
2021
Integrin α11β1 is a stromal cell-specific receptor for fibrillar collagens and overexpressed in carcinoma-associated fibroblasts (CAFs). We have investigated its direct role cancer progression by generating severe combined immune deficient (SCID) mice integrin α11 (α11) expression. The growth of A549 lung adenocarcinoma cells two patient-derived non-small cell carcinoma (NSCLC) xenografts these knockout (α11−/−) was significantly impeded, as compared with wild-type (α11+/+) SCID mice....
The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence poor diagnosis specific histological classifications lung cancer need further exploring. In this study, we investigated relationship between elevated levels three biomarkers CEA, CYFRA21-1 NSE (individually combination) metastasis, survival status prognosis patients. Eight hundred sixty eight patients including adenocarcinoma (ADC, N = 445), squamous...
Purpose . Human papillomavirus (HPV) as a risk factor for esophageal squamous cell carcinoma (ESCC) has previously been studied, but importance of HPV status in ESCC prognosis is less clear. Methods A total 105 specimens with were tested by situ hybridization 16/18 and immunohistochemistry p16 expression. The 5-year overall survival (OS) progression-free calculated relation to these markers the Cox proportional hazards model was used determine hazard ratio (HR) variables univariate...
<h3>ABSTRACT</h3> <h3>BACKGROUND AND PURPOSE:</h3> The efficacy of long-term chronic subthalamic nucleus deep brain stimulation (STN-DBS) in treating Parkinson9s Disease (PD) exhibits substantial variability among individuals. preoperative identification suitable DBS candidates through predictive means becomes crucial. Our study aims to investigate the value characterizing individualized structural covariance networks for DBS, offering patients a precise and cost-effective screening tool....
Background: Previous studies demonstrated a significant association between the albumin-globulin ratio (AGR) and various types of cancers. The aim this study was to evaluate prognostic value preoperative AGR in patients with early-stage non-small cell lung cancer (NSCLC). Methods: Patients diagnosed as NSCLC single center January 1, 2014 February 29, 2016 were retrospectively reviewed. defined serum albumin level globulin level. Receiver operating characteristics analysis performed determine...
Polymorphisms of IL-32 related closely to tumoregenesis.Two polymorphisms (rs12934561 and rs28372698) mRNA expression were conducted by SNP genotype assay real-time PCR in 423 lung cancer patients 437 controls.T allele rs28372698 associated significantly with poor prognosis moderate well-differentiated patients. TT rs12934561 survival status squamous carcinoma. decreased cancer.Our study indicates the importance polymorphism susceptibility influence cancer.
Mesenchymal stem cells (MSCs) are considered the best candidate in therapy due to their multipotent differentiation ability, low expression of co-stimulatory molecules (CD80, CD86, CD34 and HLA-II) immunosuppression effects on vivo immune responses. MSCs were now widely used clinical trials but received no encourage results. The major problem was fate engrafted could not be defined. Some studies indicated that induce response result damage rejection MSCs. As toll like receptors (TLRs)...
Background and Purpose Fulminant myocarditis (FM) is a myocardial inflammatory disease that can result from either viral diseases or autoimmune diseases. In this study, we have determined the treatment effects of immunomodulatory drugs on FM. Experimental Approach FM was induced in A/JGpt mice by intraperitoneal administration coxsackievirus B3, after which immunoglobins were administered daily injection. On seventh day, cardiac structure function using echocardiography catheterisation....
The aim of the present study was to analyze stem cell marker, Nanog gene, for diagnosis and prognosis lung cancer cases, its application in cancer. In total, 100 patients diagnosed with between April, 2013 May, 2015 were included study. randomly divided into group A (lung cancer) B (squamous carcinoma). RT-PCR used detect adjacent tissues, gene expression detected groups cells. results showed that, analysis two varied different degrees. There no significant difference regard age, gender,...
The aim of this study is to the relationship between programmed cell death-1 ligand (PD-L1) and human epidermal growth receptor 2 (HER2) clinical–pathological features gastric cancer (GC) its predictive effect on prognosis patients. A retrospective analysis was performed 113 patients undergoing GC surgery. expression PD-L1 HER2 in paired adjacent nontumor tissues detected by immunohistochemistry or fluorescence situ hybridization, relationships survival were analyzed chi-square analysis,...
Mesenchymal stem cells (MSCs) are now widely used in clinical cell‑based therapy due to their characteristics of low immunogenicity, multiple differentiation potency and the capability modulate immune responses. However, accumulated research has indicated absence engrafted MSCs because increased immunogenicity MSCs. Toll‑like receptors (TLRs) essential for innate response regulating biological function The present study human umbilical cord‑derived (UCMSCs) activated TLR8 pathway UCMSCs role...
The present study was conducted to develop new inhibitors of pancreatic lipase and alpha-glucosidase from Chinese dietary herbs. Sixty-three herbs 39 taxonomic families were selected extracted with aqueous ethanol or water. extracts then tested in vitro enzyme assays for their ability inhibit activities. Orlistat acarbose used as two positive controls. Nelumbo nucifera, Curcuma longa, Piper longum Morus alba showed strong inhibitory effects IC50 at (28.00 +/- 5.51), (5.24 0.51), (14.76...
Mesenchymal stem cells (MSCs) possess three characteristics critical to tissue regeneration; multipotency, low immunogenicity and an undifferentiated status, providing plasticity. However, increasing evidence has indicated that induction of immune response in vivo can injure reject MSC‑based tissues. Toll‑like receptors (TLRs) are a family pathogen‑associated pattern recognition receptors, which important bridging the innate adaptive responses. TLRs have been demonstrated exhibit MSC...
The aim of the present study was to investigate candidate genes and pathways associated with benign prostatic hyperplasia (BPH) diabetes. In vitro experiments were performed using normal epithelial RWPE‑1 HPr‑1 cells. cell lines treated a high‑glucose solution MTS bromodeoxyuridine assays used assess viability. Transcriptome sequencing screen genes. expression further verified by reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) western blotting. A meiotic recombination...