A5101429683- Laser Material Processing Techniques
- Cancer-related molecular mechanisms research
- Bone and Joint Diseases
- Circular RNAs in diseases
- Gastric Cancer Management and Outcomes
- Cancer Genomics and Diagnostics
- Healthcare and Venom Research
- Cancer Immunotherapy and Biomarkers
- Hip disorders and treatments
- Venomous Animal Envenomation and Studies
- Advanced Welding Techniques Analysis
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Genetic factors in colorectal cancer
- Seismic Performance and Analysis
- Foot and Ankle Surgery
- Metastasis and carcinoma case studies
- Structural Health Monitoring Techniques
- Laser-induced spectroscopy and plasma
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Colorectal and Anal Carcinomas
- Heavy Metal Exposure and Toxicity
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Orthopedic Surgery and Rehabilitation
Second Affiliated Hospital of Jilin University
2017-2025
Renji Hospital
2012-2025
Shanghai Jiao Tong University
2012-2025
Shanghai Cancer Institute
2024-2025
State Key Laboratory of Oncogene and Related Genes
2024
Guangdong University of Technology
2023-2024
Ruijin Hospital
2023-2024
Nanjing Agricultural University
2022-2023
Guilin University of Electronic Technology
2021-2023
Xihua University
2023
Steroid-induced osteonecrosis of the femoral head (SONFH) is a common debilitating orthopedic disease. The bone marrow mesenchymal stem cells (BMSCs) are type which play crucial roles in repair. adipogenic/osteogenic differentiation disorder BMSCs has been widely perceived contributing to SONFH. However, regulatory mechanism still remains unclear. Circular RNA (circRNA), kind stable ncRNA, plays important regulating gene expression via various ways. To date, there no studies uncover circRNA...
BACKGROUND: Mounting evidence indicates that nuclear receptors play a critical regulatory role in platelet pathophysiology and thrombotic disorders. Although NR4A (the receptor subfamily 4 group A) plays an important cardiovascular pathophysiology, the expression profile biological function of member 1 (NR4A1) platelets have never been reported. METHODS: We evaluated functions underlying mechanisms NR4A1 activation thrombus formation using platelet-specific NR4A1-deficient mice...
Selective protein degradation by the ubiquitin-proteasome system (UPS) is involved in all cellular processes. However, substrates and specificity of most UPS components are not well understood. Here we systematically characterized Saccharomyces cerevisiae. Using fluorescent timers, determined how loss individual affects yeast proteome turnover, detecting phenotypes for 76% E2, E3, deubiquitinating enzymes. We exploit this dataset to gain insights into N-degron pathways, which target proteins...
Abstract The canonical Wnt/β-Catenin signaling pathway is widely involved in regulating diverse biological processes. Dysregulation of the results severe consequences, such as developmental defects and malignant cancers. Here, we identified Ube2s a novel activator pathway. It modified β-Catenin at K19 via K11-linked polyubiquitin chain. This modification resulted an antagonistic effect against destruction complex/β-TrCP cascade-orchestrated degradation. As result, stability was enhanced,...
Long noncoding RNAs (lncRNAs) are critical gene expression regulators and involved in several bone diseases. To explore the potential roles of lncRNAs osteonecrosis femoral head (ONFH), we investigated for first time lncRNA profile marrow mesenchymal stem cells (BMSCs) from patients with steroid-induced ONFH (SONFH) microarray bioinformatics analysis. A total 1878 838 mRNAs were significantly up-regulated while 1842 1937 statistically down-regulated SONFH group compared control group. The...
BACKGROUND:Globally, gastric cancer (GC) is the third most common source of cancer-associated mortality. The aim this study was to identify key genes and circular RNAs (circRNAs) in GC diagnosis, prognosis, therapy further explore potential molecular mechanisms GC. MATERIAL AND METHODS:Differentially expressed (DEGs) circRNAs (DE circRNAs) between tissues adjacent non-tumor were identified from 3 mRNA circRNA expression profiles. Functional analyses performed, protein–protein interaction...
Epithelial-to-mesenchymal transition (EMT) is a pivotal cellular phenomenon involved in tumour metastasis and progression. In gastric cancer (GC), EMT the main reason for recurrence postoperative patients. Acacetin exhibits various biological activities. However, inhibitory effect of acacetin on GC still unknown. Herein, we explored possible mechanism vitro vivo.In vitro, MKN45 MGC803 cells were treated with acacetin, after which cell viability was detected by CCK-8 assays, migration...
Osteosarcoma (OS) is a primary malignant bone tumor with high fatality rate. Many circRNAs have been proved to play important roles in the pathogenesis of some diseases. However, occurrence OS remains little known.The circular RNA (circRNA) expression file GSE96964 dataset, which included seven osteosarcoma cell lines and one control sample (osteoblast line), was downloaded from Gene Expression Omnibus (GEO) database explore potential function by competing endogenous (ceRNA) analysis. Three...
Abstract Background: This study aimed to investigate the safety and reliability of using bioabsorbable screws for fixation chevron osteotomy in treatment hallux valgus (HV) deformity. Methods: Clinical cases HV deformities our hospital between December 2018 August 2022 were retrospectively summarised compare preoperative imaging indices with those at final follow-up session, including angle (HVA), intermetatarsal (IMA) tibial sesamoid position (TSP). The American Orthopaedic Foot Ankle...
In the bioremediation process, coexistence of lead (Pb) and cadmium causes complex toxicity, resulting in difficulty bioremediation. This study investigated physiological responses bioaccumulation mechanisms typical filamentous fungus Aspergillus niger under Pb Cd. Four treatments were set up, i.e., control, sole Pb, Cd, The morphology A. observed by scanning electron microscopy (SEM) transmission (TEM), respectively. Then, nano-scale secondary ion mass spectrometry (NanoSIMS) was applied to...
Oct4 physically interacts with Sox2 by anti bait coimmunoprecipitation (View interaction)
Multiple gene polymorphisms have been demonstrated to correlate with the susceptibility osteonecrosis of femoral head (ONFH). However, as a complex disease induced by multiple genes, development ONFH has rarely reported involve in interaction. In this study, we first explored association 10 variants interactions receptor activator nuclear factor-kappa B (RANK), RANK ligand (RANKL), osteoprotegerin (OPG), tumor necrosis factor receptor-associated 6 (TRAF6), and activated T cells cytoplasmic 1...
ARID1A deletion mutation contributes to improved treatment of several malignancies with immune checkpoint inhibitors (ICIs). However, its role in modulating tumor microenvironment (TIME) gastric cancer (GC) remains unclear. Here, we report an increase CD8+ T cells infiltration GC patients ARID1A-mutation (MUT), which enhances sensitivity ICIs. Kaplan-Meier survival analysis showed that gastrointestinal benefit from immunotherapy. Transcriptome implicated regulates STAT5 downstream targets...
Purpose . Establishing prognostic gene signature to predict clinical outcomes and guide individualized adjuvant therapy is necessary. Here, we aim establish the efficacy of a that closely related tumor immune microenvironment (TIME). Methods Results There are 13,035 expression profiles from 130 samples non-small cell lung cancer (NSCLC) in data set GSE103584. A 5-gene was identified by using univariate survival analysis Least Absolute Shrinkage Selection Operator (LASSO) build risk models....
It has been well known that the degeneration of hip articular cartilage with osteonecrosis femoral head (ONFH) increases instability and accelerates development process ONFH. A better understanding expression chondrogenesis-related arthritis-related genes along progression ONFH seems to be essential for further insight into molecular mechanisms pathogenesis.We analyzed differentially expressed gene profile (GSE74089) human The functions pathway enrichments (DEGs) were via GO KEGG analysis....
Abstract Rapid estimation of post-earthquake building damage and loss is very important in urgent response efforts. The current approach leaves much room for improvement estimating ground motion correctly incorporating the uncertainty spatial correlation loss. This study proposed a new rapidly with reasonable accuracy. method interpolates based on observed using Ground Motion Prediction Equation (GMPE) as weight. It samples seismic quantile considering that expressed by Gaussian copula,...
Recent studies have shown that low-density lipoprotein receptor-related protein 1b (LRP1B), as a potential tumor suppressor, is implicated in the response to immunotherapy. The frequency of LRP1B mutation gene high many cancers, but its role gastric cancer (GC) has not been determined.The prognostic value cohort containing 100 patients having received radical gastrectomy for stage II-III GC was explored. By analyzing data mRNA, risk score differentially expressed genes (DEGs) between...