A5100735131- Bone and Joint Diseases
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Hematopoietic Stem Cell Transplantation
- Circular RNAs in diseases
- Hip disorders and treatments
- Chemokine receptors and signaling
- Glycosylation and Glycoproteins Research
- Soybean genetics and cultivation
- Osteoarthritis Treatment and Mechanisms
- Plant Molecular Biology Research
- Cerebrovascular and Carotid Artery Diseases
- Immune Cell Function and Interaction
- Coronary Interventions and Diagnostics
- Cytokine Signaling Pathways and Interactions
- Orthopedic Infections and Treatments
- HER2/EGFR in Cancer Research
- Retinoids in leukemia and cellular processes
- Bone health and treatments
- Cancer Cells and Metastasis
- Hematological disorders and diagnostics
- Monoclonal and Polyclonal Antibodies Research
- Plant Stress Responses and Tolerance
- RNA modifications and cancer
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Shenyang Pharmaceutical University
2024-2025
Jilin University
2016-2025
Nanjing University of Aeronautics and Astronautics
2025
Beijing Hospital
2022-2024
China Agricultural University
2015-2024
Second Affiliated Hospital of Jilin University
2016-2024
Weifang People's Hospital
2024
Jiaxing University
2024
Qingdao University
2024
Steroid-induced osteonecrosis of the femoral head (SONFH) is a common debilitating orthopedic disease. The bone marrow mesenchymal stem cells (BMSCs) are type which play crucial roles in repair. adipogenic/osteogenic differentiation disorder BMSCs has been widely perceived contributing to SONFH. However, regulatory mechanism still remains unclear. Circular RNA (circRNA), kind stable ncRNA, plays important regulating gene expression via various ways. To date, there no studies uncover circRNA...
Pancreatic cancer remains one of the leading causes cancer-related deaths worldwide. ductal adenocarcinoma (PDAC) is most common type pancreatic tumor. Many circular RNAs (circRNAs) have proven to play vital roles in physiological and pathological processes tumorigenesis; however, their biogenesis PDAC unclear. In this study, expression profiles circRNAs from 10 tissues paired adjacent nontumor were analyzed through RNA sequencing analysis. An enrichment analysis was employed predict...
Abstract Background Salinity, alkalinity, and drought stress are the main abiotic factors affecting plant growth development. Sophora alopecuroides L., a perennial leguminous herb in genus , is highly salt-tolerant sand-fixing pioneer species distributed mostly Western Asia northwestern China. Few studies have assessed responses to S. . The transcriptome of genes that confer stress-tolerance this has not previously been sequenced. Our objective was sequence analyze transcriptome. Results...
A certain number of epithelial cells in intestinal crypts are DNA damage resistant and contribute to regeneration. However, the cellular mechanism underlying regeneration remains unclear. Using lineage tracing, we show that marked by an Msi1 reporter (Msi1+) right above Lgr5high exhibit resistance. Single-cell RNA sequencing reveals Msi1+ heterogeneous with majority being stem (ISCs). The damage-resistant subpopulation is characterized low-to-negative Lgr5 expression more rapidly cycling...
Corticotropin releasing factor (CRF) network in the oval nucleus of bed nuclei stria terminalis (ovBNST) is generally indicated stress, but its role female-biased susceptibility to anxiety unknown. Here, we established a stress paradigm. We found that CRF release ovBNST during showed pattern, and neurons were more prone be hyperexcited female mice both vitro vivo studies. Moreover, optogenetic modulation exchange activation pattern between male could reverse their anxiety. Last, receptor...
HA2-16 ferritin nanoparticles induce stem-directed neutralizing antibodies by H3 influenza virus boost.
Long noncoding RNAs (lncRNAs) are critical gene expression regulators and involved in several bone diseases. To explore the potential roles of lncRNAs osteonecrosis femoral head (ONFH), we investigated for first time lncRNA profile marrow mesenchymal stem cells (BMSCs) from patients with steroid-induced ONFH (SONFH) microarray bioinformatics analysis. A total 1878 838 mRNAs were significantly up-regulated while 1842 1937 statistically down-regulated SONFH group compared control group. The...
Mung bean (Vigna radiata L.) is an important edible in the human diet worldwide. However, its growth, development, and yield may be restricted or limited by insufficient unbalanced nitrogen (N), phosphorus (P), potassium (K) fertilization. Despite this, there are few long-term studies of effects varying levels N, P, K combined fertilizers optimal fertilization for improving mung quality. This study was conducted to optimize strategies high improve components (pods per plant, seeds pod,...
Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intestinal epithelial cells facilitates small both three-dimensional cultured organoids mouse models. As shown the study, during post-irradiation regeneration, AA positively regulates cell by upregulating expression Ascl2 activating WNT signaling, but negatively...
Salt stress seriously restricts crop yield and quality, leading to an urgent need understand its effects on plants the mechanism of plant responses. Although phytohormones are crucial for responses salt stress, role phytohormone signal transduction in stress-resistant species such as Sophora alopecuroides has not been reported. Herein, we combined transcriptome metabolome analyses evaluate expression changes key genes metabolites associated with hormone S. roots under 0 h 72 h. Auxin,...
440 Background: Approximately 12–23% G/GEJC patients have human epidermal growth factor receptor 2 (HER2)-positive disease. Despite survival benefit from combination therapy with trastuzumab and chemotherapy, the prognosis remains unsatisfactory; more effective treatments are needed. This phase study is evaluating of HLX22 (an anti-HER2 monoclonal antibody targeting a different epitope than trastuzumab), trastuzumab, XELOX chemotherapy as first-line treatment for advanced/metastatic G/GEJC....
Abstract Soybean isoflavones, natural phytoestrogens within the flavonoid family, exhibit diverse physiological benefits such as anticancer, antioxidant, and cardioprotective properties. Yet, underlying biosynthetic pathways remain unclear. Research is required to get better knowledge of soybean isoflavone production its potential uses. Our work thoroughly examined R2R3‐MYB subclass in discovered a new MYB transcription factor, GmMYB3a , which shares significant similarities with Arabidopsis...
Objective: Summarize the clinical characteristics, treatment methods, and prognosis of paraneoplastic pemphigus with oral lesions, identify commonalities features to provide better references for diagnosis this disease. Methods: A retrospective analysis was conducted on case data photos 9 patients accompanied by lesions treated in Internal Medicine Ward Department Stomatology Beijing Hospital from September 2017 December 2023, characteristics were summarized analyzed. Results: All had...
This study delves into the pivotal role of biochar particle size and addition ratio in mitigating cadmium (Cd) contamination paddy-upland soils, with a specific focus on curbing Cd uptake by Chinese cabbage (Brassica chinensis L.) during transition from paddy to upland cultivation. Through meticulously designed laboratory experiment, we uncovered that biochar's adsorption capacity for soil is markedly lower than its maximum adsorptive as determined kinetics, potentially due competitive other...
Osteosarcoma (OS) is a primary malignant bone tumor with high fatality rate. Many circRNAs have been proved to play important roles in the pathogenesis of some diseases. However, occurrence OS remains little known.The circular RNA (circRNA) expression file GSE96964 dataset, which included seven osteosarcoma cell lines and one control sample (osteoblast line), was downloaded from Gene Expression Omnibus (GEO) database explore potential function by competing endogenous (ceRNA) analysis. Three...
BACKGROUND Steroid-induced osteonecrosis of the femoral head (SONFH) is a common orthopedic disease associated with application glucocorticoid (GC). In this study, we detected microRNAs (miRNAs) differentially expressed in bone marrow mesenchymal stem cells (BMSCs) from SONFH patients, and target gene predictions were performed, functions genes was verified. MATERIAL AND METHODS BMSCs collected patients neck fracture (FNF) constituted group (n=3) FNF (control) (n=3), respectively. MiRNA...
Hepatocellular carcinoma (HCC) accounts for a significant proportion of liver cancer, which has become the second most common cause cancer-related mortality worldwide. To investigate potential mechanisms invasion and progression HCC, bioinformatics analysis validation by qRT-PCR were performed. We found 237 differentially expressed genes (DEGs) including EGR1, FOS, FOSB, three transcription factors. Subsequently, we constructed TF-gene network miRNA-TF-mRNA based on data obtained from mRNA...