A5058283254- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Contact Dermatitis and Allergies
- Immunotherapy and Immune Responses
- Skin and Cellular Biology Research
- Autoimmune Bullous Skin Diseases
- Vascular Malformations and Hemangiomas
- T-cell and B-cell Immunology
- Vascular Tumors and Angiosarcomas
- Allergic Rhinitis and Sensitization
- Advanced Fluorescence Microscopy Techniques
- Dermatological and Skeletal Disorders
- Psoriasis: Treatment and Pathogenesis
- Eosinophilic Disorders and Syndromes
- Inflammatory Myopathies and Dermatomyositis
- Autoimmune and Inflammatory Disorders
- Connective tissue disorders research
- Acne and Rosacea Treatments and Effects
- Herpesvirus Infections and Treatments
- Patient-Provider Communication in Healthcare
- Optical Coherence Tomography Applications
- Advancements in Transdermal Drug Delivery
- Genetic and rare skin diseases.
Chinese Academy of Medical Sciences & Peking Union Medical College
2024-2025
UNSW Sydney
2025
St Vincent's Hospital Sydney
2021-2025
St Vincent's Hospital
2021-2022
Skin Health Institute
2021-2022
Skin and Cancer Foundation
2021
Institute of Dermatology
2021
The University of Sydney
2013-2020
Royal Prince Alfred Hospital
2013-2020
Northern Sydney Local Health District
2020
Site-specific differences in skin response to pathogens and the course of cutaneous inflammatory diseases are well appreciated. The composition localization leukocytes has been studied extensively using histology flow cytometry. However, precise three-dimensional (3D) distribution distinct immune cell subsets within at different body sites requires visualization intact living skin. We used intravital multiphoton microscopy transgenic reporter mice combination with quantitative cytometry...
The dysfunctional skin barrier in eczema patients may be attributed to decreased levels of ceramides the stratum corneum. aim this study was determine whether a two-part system consisting ceramide-dominant physiological lipid-based moisturizing cream and cleanser could ameliorate signs symptoms moderate adults over 28 days compared placebo. Assessments were conducted at baseline every 7 thereafter. Eczema area severity index score significantly across all time points both groups (P < .0001),...
Objective: Summarize the clinical characteristics, treatment methods, and prognosis of paraneoplastic pemphigus with oral lesions, identify commonalities features to provide better references for diagnosis this disease. Methods: A retrospective analysis was conducted on case data photos 9 patients accompanied by lesions treated in Internal Medicine Ward Department Stomatology Beijing Hospital from September 2017 December 2023, characteristics were summarized analyzed. Results: All had...
Background Multiphoton microscopy (MPM) is a novel imaging technology that has recently become applicable for diagnostic purposes. The use of (near) infrared light in MPM allows deep tissue imaging. In addition, this modality exploits the autofluorescent nature extracellular matrix fibres within skin. Objectives To quantitate structure and abundance elastic human dermis three dimensions utilizing signals generated by objective examination elastin-related skin disorders. Methods...
ABSTRACT A 57‐year‐old woman with prior exposure to bisphosphonates developed myalgia, proximal muscle weakness and lichenoid rash over the upper extremities face 3 days after infusion of zoledronic acid for management osteoporosis. The diagnosis dermatomyositis was made on basis clinical, laboratory histological findings. This is first report drug‐induced secondary acid.
ABSTRACT Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare subtype of and can be associated with various connective tissue disorders. It difficult to treat past therapies include surgical excision, dermabrasion, electrodessication curettage, cryotherapy laser therapy. We present case middle‐aged woman PLCNA CREST (calcinosis, Raynaud phenomenon, oesophageal motility disorders, sclerodactyly telangiectasia) syndrome Sjögren's responding cyclophosphamide no new amyloid deposits...
Une observation chez une femme de 45 ans a Singapour. Le tableau clinique simule tuberculose miliaire: amaigrissement, sueurs nocturnes, affaiblissement rapide, image typique la radiographie thoracique. Les biopsies foie et rate montrent des cellules reticuloendotheliales fortement parasitees par Histoplasma capsulatum
Introduction: Novel treatments are needed for eosinophilic esophagitis (EoE). IRL201104 is a novel immunomodulatory peptide derived from mTB Chaperonin 60.1 with short half-life (∼10-15mins) but long-lasting pharmacodynamic effect across multiple inflammatory cell types in preclinical models. The aim of this Phase 2a trial (NCT05084963) was to evaluate the safety, efficacy, and on biomarkers EoE patients. Methods: This randomized double-blind placebo controlled study enrolled 36 adults...
Acquired progressive lymphangioma (APL) is a rare benign lymphatic proliferation, 1 typically arising as solitary lesion on the trunk and limbs 2 in both children adults. 1,3t can appear fl at, indurated or plaque exhibits range of appearances from red, brown, violaceous yellow.Histological fi ndings need to be distinguished more aggressive entities challenging without further history.A 75-year-old man Italian descent presented with an ill defi ned scaly, slightly indurated, erythematous...
Abstract Background Clinical trial recruitment is challenging for investigators who often overestimate the pool of qualified, willing subjects. Moreover, there a paucity literature, particularly in dermatology, regarding and comparative success advertising strategies. Methods Both ‘traditional’ (physician referral, newspaper radio advertisements, letterbox drops, posters/flyers, word‐of‐mouth) ‘modern’ (patient services, social media, Google websites, email) methods were used to enrol 100...
Pseudoxanthoma elasticum (PXE) is a multisystem disorder characterized by ectopic mineralization of connective tissues with primary manifestations in the skin, eyes and cardiovascular system. The classic forms PXE are caused mutations ABCC6 gene encoding protein, expressed primarily liver. Cutis laxa (CL) manifests loose sagging skin loss recoil. In 2009 we investigated 19-year-old patient overlapping cutaneous features CL, together alpha thalassaemia. Genetic analysis failed to identify...
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