A5048159118- Pancreatic and Hepatic Oncology Research
- RNA modifications and cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer-related molecular mechanisms research
- Cancer Mechanisms and Therapy
- PI3K/AKT/mTOR signaling in cancer
- Liver Disease Diagnosis and Treatment
- Ferroptosis and cancer prognosis
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Cancer, Hypoxia, and Metabolism
- Nanoplatforms for cancer theranostics
- Mitochondrial Function and Pathology
- Metastasis and carcinoma case studies
- Berberine and alkaloids research
- Cancer Research and Treatments
- Organic Electronics and Photovoltaics
- Copper-based nanomaterials and applications
- Cancer Immunotherapy and Biomarkers
- Advanced Photocatalysis Techniques
- Pharmacological Effects of Natural Compounds
- Text and Document Classification Technologies
- Machine Learning in Bioinformatics
Second Affiliated Hospital of Jilin University
2016-2025
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2024
Jilin University
2013-2022
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry
2021-2022
Jilin Province Science and Technology Department
2021
Jilin Medical University
2021
Union Hospital
2016
Pyroptosis, which is a mode of programmed cell death, has proven effective for cancer therapy. However, efficient pyroptosis inducers tumor treatment are limited. This study proposes biodegradable K3ZrF7:Yb/Er upconversion nanoparticles (ZrNPs) as immunotherapy. ZrNPs, similar to ion reservoirs, can be dissolved inside cells and release high amounts K+ [ZrF7]3- ions, resulting surge in intracellular osmolarity homeostasis imbalance. further induces an increase reactive oxygen species (ROS),...
Photocatalytic hydrogen evolution (PHE) over semiconductor photocatalysts is usually constrained by the limited light-harvesting and separation of photogenerated electron-hole pairs. Most reported systems focusing on PHE are facilitated consuming photoinduced holes with organic sacrificial electron donors (SEDs). The introduction SEDs not only causes environmental problem, but also increases cost reaction. Herein, a dual-functional photocatalyst developed morphology sandwiched-like hollowed...
The tumor cells have some metabolic characteristics of the original tissues, and metabolism is closely related to autophagy. However, mechanism autophagy in chemotherapeutic drug resistance still poorly understood. In this study, we investigated role glucose by using cholangiocarcinoma QBC939 with primary cisplatin hepatocellular carcinoma HepG2 cells. We found that had a higher capacity for uptake, consumption, lactic acid generation, activity pentose phosphate pathway compared cells, PPP...
Abstract Vascular disrupting agents (VDAs) have great potential for cancer treatment. Poly( l ‐glutamic acid)‐combretastatin A4 conjugate (PLG‐CA4) is a novel class of VDAs. Though it has notable antitumor activity, can induce host immune responses that promote tumor growth. Here, PLG‐CA4 induces the polarization tumor‐associated macrophages (TAMs) toward M2‐like phenotype in 4T1 metastatic breast (Control 30% vs 53%; p < 0.05). Compared to monotherapy PLG‐CA4, inhibition phosphoinositide...
Currently, antitumor drugs show limited clinical outcomes, mainly due to adaptive resistance. Clinical evidence has highlighted the importance of tumor microenvironment (TME) and tumor-associated macrophages (TAMs) in response conventional drugs. Preclinical studies that TAMs following agent can be reprogrammed an immunosuppressive phenotype proangiogenic activities through different mechanisms, mediating drug resistance poor prognosis. Potential extrinsic inhibitors targeting repolarize...
The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy clinical trials, several studies provide promising combination strategies to substantially maximize outcomes. Besides its direct impact on regulating cells survival, are also demonstrated an immunomodulatory based the tumor microenvironment. Inhibition of leukocyte-enriched isoforms may...
Abstract Objectives The genotoxicity of cisplatin towards nuclear DNA is not sufficient to explain the resistance hepatocellular carcinoma (HCC) cells; interacts with many organelles, which can influence sensitivity. Here, we explored role mitochondrial‐lysosomal crosstalk in HCC cells. Materials and methods Huh7 HepG2 cells were subjected different treatments. Flow cytometry was conducted detect mitochondrial reactive oxygen species, mass, lysosomal function, membrane potential apoptosis....
Deep blue luminescent materials play a crucial role in the organic light-emitting diodes (OLEDs). In this work, novel deep molecule based on hybridized local and charge-transfer (HLCT) excited state was reported with emission wavelength of 423 nm. The OLED material achieved high maximum external quantum efficiency (EQE) 4% good color purity. results revealed that locally-excited (LE)-dominated HLCT had obvious advantages short narrow spectrum emission. What is more, experimental theoretical...
Hepatocellular carcinoma (HCC) has a poor prognosis due to its high malignancy, rapid disease progression, and the presence of chemotherapy resistance. Long-stranded non-coding RNAs (lncRNAs) affect many malignant tumors, including HCC. However, their mechanism action in HCC remains unclear. This study aimed clarify role DUXAP8 regulating phenotype resistance Using an vivo xenograft tumor model, regulatory functions mechanisms lncRNA progression response were explored. It was found that...
Fibrinogen is an important plasma protein composed of three polypeptide chains, fibrinogen alpha (FGA), beta, and gamma. Apart from being inflammation regulator, also plays a role in tumor progression. Liver cancer usually has poor prognosis, with chronic hepatitis the main cause liver cirrhosis hepatocellular carcinoma (HCC). FGA serves as serological marker for hepatitis, but its relationship remains unclear. Through bioinformatics analysis agarose gel electrophoresis, we found that was...
Hepatocellular carcinoma (HCC) accounts for a significant proportion of liver cancer, which has become the second most common cause cancer-related mortality worldwide. To investigate potential mechanisms invasion and progression HCC, bioinformatics analysis validation by qRT-PCR were performed. We found 237 differentially expressed genes (DEGs) including EGR1, FOS, FOSB, three transcription factors. Subsequently, we constructed TF-gene network miRNA-TF-mRNA based on data obtained from mRNA...
Background: This study will explore the therapeutic value of traditional Chinese medicine (TCM) in Hepatocellular Carcinoma (HCC) through meta-analysis, combined with network pharmacology analysis. Methods: The results randomized controlled trials on TCM and HCC were retrieved summarized from multiple databases. effective active com-pounds target genes high-frequency obtained using TCMSP database, disease targets acquired public database. analysis was used to get core investigate potential...