A5100456015- RNA Research and Splicing
- RNA modifications and cancer
- CAR-T cell therapy research
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Cancer Immunotherapy and Biomarkers
- Protein Tyrosine Phosphatases
- Wnt/β-catenin signaling in development and cancer
- Advanced Proteomics Techniques and Applications
- Phytochemical compounds biological activities
- Cancer, Hypoxia, and Metabolism
- Medical Research and Treatments
- vaccines and immunoinformatics approaches
- Renal and related cancers
- Cancer-related gene regulation
- Physiological and biochemical adaptations
- Crustacean biology and ecology
- Cancer Research and Treatments
- Blood groups and transfusion
- Pharmacological Effects of Natural Compounds
- Ferroptosis and cancer prognosis
- Pancreatic and Hepatic Oncology Research
- Proteoglycans and glycosaminoglycans research
- Ubiquitin and proteasome pathways
- Natural Compounds in Disease Treatment
Tsinghua–Berkeley Shenzhen Institute
2025
Second Affiliated Hospital of Jilin University
2018-2024
Beijing University of Chinese Medicine
2019-2021
Nanjing University of Chinese Medicine
2020
Jiangsu Provincial Hospital of Traditional Chinese Medicine
2019
Sichuan University
2018
Bengbu Medical College
2018
Hangzhou First People's Hospital
2016
Huazhong Agricultural University
2015
Qingdao National Laboratory for Marine Science and Technology
2015
Increasing evidence supports the association of microRNA with tumor occurrence and development. However, expression miR-6875-3p its role in cell proliferation, invasion metastasis hepatocellular carcinoma (HCC) remains elusive.The BTG2 HCC tissues lines was detected by using situ hybridization, immunohistochemistry qRT-PCR, respectively. A western blot assay, qRT-PCR Luciferase reporter assay were employed to study interaction between BTG2. Cell proliferation measured MTT, transwell matrigel...
Currently, antitumor drugs show limited clinical outcomes, mainly due to adaptive resistance. Clinical evidence has highlighted the importance of tumor microenvironment (TME) and tumor-associated macrophages (TAMs) in response conventional drugs. Preclinical studies that TAMs following agent can be reprogrammed an immunosuppressive phenotype proangiogenic activities through different mechanisms, mediating drug resistance poor prognosis. Potential extrinsic inhibitors targeting repolarize...
The phosphoinositide 3-kinase (PI3K) pathway shows frequent aberrant alterations and pathological activation in breast cancer cells. While PI3K inhibitors have not achieved expectant therapeutic efficacy clinical trials, several studies provide promising combination strategies to substantially maximize outcomes. Besides its direct impact on regulating cells survival, are also demonstrated an immunomodulatory based the tumor microenvironment. Inhibition of leukocyte-enriched isoforms may...
The Piwi subfamily is one of two Argonaute family proteins, which are characterized by the presence and Piwi‑Argonaute‑Zwille domains, well known for their role in RNA silencing. Hiwi, a human member subfamily, restricted to germ line, where it binds Piwi‑interacting RNAs functions stem cell self‑renewal gametogenesis. Previous reports have indicated that abnormal Hiwi expression may be associated with poor prognosis numerous types cancer, including hepatocellular carcinoma (HCC). However,...
Alternative splicing (AS) is an important regulatory mechanism that greatly contributes to eukaryotic transcriptome diversity. A substantial amount of evidence has demonstrated AS complexity relevant evolution, development, adaptation, and complexity. In this study, six teosinte ten maize transcriptomes were sequenced analyze changes signatures selection in domestication improvement.In teosinte, 13,593 highly conserved genes, including 12,030 multiexonic detected. By identifying isoforms...
Hepatocellular carcinoma (HCC) accounts for a significant proportion of liver cancer, which has become the second most common cause cancer-related mortality worldwide. To investigate potential mechanisms invasion and progression HCC, bioinformatics analysis validation by qRT-PCR were performed. We found 237 differentially expressed genes (DEGs) including EGR1, FOS, FOSB, three transcription factors. Subsequently, we constructed TF-gene network miRNA-TF-mRNA based on data obtained from mRNA...
Objective: The aim of the present network meta-analysis (NMA) was to explore comparative effectiveness and safety different Chinese herbal injections (CHIs) combined with FOLFOX regimen versus alone for colorectal cancer (CRC). Methods: A comprehensive search randomized controlled trials (RCTs) performed regard CHIs treating CRC in several electronic databases up July 2016. quality assessment included RCTs conducted according Cochrane risk bias tool. Standard pair-wise Bayesian NMA were...
Abstract MicroRNAs are a class of small non-coding RNAs which act as oncogenes or tumor suppressors through targeting specific mRNAs. Colorectal cancer (CRC) is one the most common malignancies worldwide. MiR-3622a-3p found to be decreased in colorectal by analyzing data from TCGA database and there few reports about role miR-3622a-3p cancers. Our research aimed explore effects on CRC. was down-regulated CRC tissues cells qRT-PCR. The effect proliferation, apoptosis, cell cycle, migration...
The cell surface adhesion receptor CD44 reportedly affects the development and progression of cancers. Moreover, gene rs187115 polymorphism appears to be genetic determinant cancer susceptibility. We investigated whether is associated with colorectal (CRC) risk prognosis. enrolled 669 CRC cases 826 controls in this three-center case-control study a Chinese Han population. All individuals were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry....
Deacetylisovaltratum (DI) is isolated from the traditional Chinese herbal medicine Patrinia heterophylla Bunge, which exhibits anti-cancer activity. Here, we investigated effects of DI on human gastric carcinoma cell lines in vitro and elucidated its mechanisms. Human AGS HGC-27 were treated with DI, viability was detected MTT assay. Cell cycle stages, apoptosis mitochondrial membrane potential measured using flow cytometry. Protein levels analyzed by Western blotting. Tubulin polymerization...
Serum proteins carry out several functions in the circulation, including transfer, immunological functions, messenger coagulation, and regulation of homeostasis. To investigate changes serum that occur during development, proteomes embryonic 15.5 (E15.5) fetuses newborn rats were compared using LC-MS/MS.A total 958 identified at both developmental stages. The proteome pattern was to E15.5 by relative quantitation. expression patterns hemoglobin subunits different two stages, with most having...
Abstract Background Tripterygium hypoglaucum Hutch (THH) both has prominent efficacy and unwarranted toxicity in the treatment of autoimmune diseases. Nevertheless, its pharmacological toxicological profiles still remain to be elucidated. In current study, network pharmacology approach was applied identify synergistic interaction mechanism for THH from a holistic perspective. Methods The compounds were collected using literature retrieval relevant databases. After production putative...
Resonance light scattering has been extensively used in the detection of concentrations biological macromolecules. For development resonance based protein sensor at point-of-care, it is necessary to make enhanced wavelength move long wave direction improve sensitivity. A method for determination was developed presence tetra-amino copper phthalocyanine (TACuPc) by technique. In acidic solution, interaction between TACuPc and human serum albumin yielded strongly signals 454 nm intensity...