A5002047948- Lung Cancer Treatments and Mutations
- Cancer therapeutics and mechanisms
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Cancer Treatment and Pharmacology
- Kruppel-like factors research
- Lung Cancer Research Studies
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Cancer, Hypoxia, and Metabolism
- Protein Tyrosine Phosphatases
- Quinazolinone synthesis and applications
- Autophagy in Disease and Therapy
- Cancer-related gene regulation
- Histone Deacetylase Inhibitors Research
- Ubiquitin and proteasome pathways
- Metal complexes synthesis and properties
- RNA modifications and cancer
- PI3K/AKT/mTOR signaling in cancer
- Synthesis and Biological Evaluation
- Renal cell carcinoma treatment
- Toxoplasma gondii Research Studies
- Bioactive Compounds and Antitumor Agents
- Protein Degradation and Inhibitors
Hangzhou First People's Hospital
2016-2024
Zhejiang University
2018-2024
Westlake University
2024
Hangzhou City University
2023
City College
2023
City University
2023
Zhejiang Chinese Medical University
2019
Lanzhou University Second Hospital
2012
Lanzhou University
2012
Lung cancer is a leading cause of cancer-related deaths, and the most common type lung adenocarcinoma (LUAD). LUAD frequently diagnosed in people who never smoked, patients are always at advanced inoperable stages, prognosis ultimately poor. Thus, there an urgent need for development novel targeted therapeutics to suppress progression. In this study, we demonstrated that expression DNA replication sister chromatid cohesion 1 (DSCC1) was higher samples than normal tissues, overexpression...
Abstract Background Hepatocellular carcinoma (HCC) accounts for the majority of liver cancer cases, while metastasis is considered leading cause HCC-related death. However, currently available treatment strategies efficient suppression are limited. Therefore, novel therapeutic targets to inhibit and effectively treat HCC urgently required. Methods Wound healing Transwell assays were used determine migration invasion abilities cells in vitro. Quantitative real-time PCR (qRT-PCR), protein...
Hepatocellular carcinoma (HCC) is an extremely heterogeneous malignant tumor with a high morbidity and mortality. Circular RNAs (circRNAs) are noncoding stability, organ/tissue/cell-specific expression conserved across species. Accumulating evidence suggested that circRNAs play crucial roles as microRNA sponges, protein scaffolds, recruiters could even polypeptide encoders. Many studies have since revealed were aberrantly expressed in HCC acted modulators of carcinogenesis progression....
As patients with non‑small cell lung cancer (NSCLC) and wild‑type epidermal growth factor receptor (EGFR) are resistant to treatment erlotinib or gefitinib, potential chemosensitizers required potentiate EGFR NSCLC cells erlotinib/gefitinib treatment. The present study reported that shikonin could sensitize the anticancer activity of in cells. Furthermore, mitochondrial‑mediated apoptosis induced by In addition, demonstrated induce activating reactive oxygen species (ROS)‑mediated...
Hypoxia promotes drug resistance and induces the expression of hypoxia inducible factor (HIF)‑1α in liver cancer cells. However, to date, no selective HIF‑1α inhibitor has been clinically approved. The aim this study is investigate a drug‑targetable molecule that can regulate under hypoxia. present demonstrated hyperactivation dual‑specificity tyrosine‑phosphorylation‑regulated kinase 1A (DYRK1A)/HIF‑1α signaling was associated with an increased risk cancer. In addition, DYRK1A knockdown...
Deacetylisovaltratum (DI) is isolated from the traditional Chinese herbal medicine Patrinia heterophylla Bunge, which exhibits anti-cancer activity. Here, we investigated effects of DI on human gastric carcinoma cell lines in vitro and elucidated its mechanisms. Human AGS HGC-27 were treated with DI, viability was detected MTT assay. Cell cycle stages, apoptosis mitochondrial membrane potential measured using flow cytometry. Protein levels analyzed by Western blotting. Tubulin polymerization...
Vinpocetine is widely used to treat cerebrovascular diseases. However, the effect of vinpocetine hepatocellular carcinoma (HCC) has not been investigated. In this study, we revealed that was associated with antiproliferative activity in HCC cells, but induced cytoprotective autophagy, which restricted its antitumor activity. Autophagy inhibitors improved cells. Sorafenib effective advanced HCC, autophagy by sorafenib indistinct. We demonstrated plus suppressed activated cells and...
Inositol Polyphosphate-5-Phosphatase B (INPP5B), a inositol 5-phosphatase, plays an important role in many biological processes through phosphorylating PI(4,5)P2 and/or PI(3,4,5)P3 at the 5-position. Nevertheless, little is known about its function and cellular pathways tumors. This study aims to investigate potential of INPP5B as diagnostic prognostic biomarker for lung adenocarcinoma (LUAD), well functions molecular mechanisms LUAD.TCGA, GEO, CTPAC, HPA datasets were used differential...
Hepatocellular carcinoma (HCC) is associated with some of the highest cancer-associated mortality rates. Histone deacetylase (HDAC) inhibitors anti-HCC activities have been shown to promote Snail-induced metastasis. In present study, it was that BAY 87-2243, a hypoxia-inducible transcription factor-1α inhibitor, could enhance effects HDAC inhibitors, including trichostatin A and vorinostat. addition, 87-2243 plus exhibited synergistic cytotoxicity induced significant cell death in Hep3B...
Abstract Background Breast cancer is the most common among women in China. Amplification of Human epidermal growth factor receptor type 2 (HER2) gene present and overexpressed 18–20% breast cancers historically has been associated with inferior disease-related outcomes. There increasing interest de-escalation therapy for low-risk disease. This study analyzes cost-effectiveness Doxorubicin/ Cyclophosphamide/ Paclitaxel/ Trastuzumab (AC-TH) Docetaxel/Carboplatin/Trastuzumab(TCH) from payer...
Platinum compounds, such as cisplatin, carboplatin, oxaliplatin and nedaplatin, are widely used to treat a number of solid malignancies. Nedaplatin is second-generation platinum complex, based on its pronounced anti-cancer activities against several tumors being equivalent that but with lower nephrotoxicity. In this context, the present study aimed investigate potential effect by combining nedaplatin ABT-737. It was found greatly increased ABT-737-mediated apoptosis in A549 95-D cells,...
Abstract Non-small cell lung cancer (NSCLC) is the most common subtype of cancer, and prognosis NSCLC patients still poor particularly for with metastatic disease. Thus, extending knowledge about mechanism metastasis critical treatment. We demonstrated that hsa_circ_0073052 (circPOLK) was overexpressed in blood exosomes from than those healthy people. Furthermore, circPOLK identified as a circular RNA generated host gene POLK by back-splicing cells. Although knockdown could not affect...
Abstract Clear cell renal carcinoma (ccRCC) is the most common type of kidney with poor prognosis and high mortality. Mutation-mediated inactivation Von Hippel Lindau (VHL) a hallmark feature ccRCC, it leads to accumulation hypoxia-inducible factors (HIFs) cancer progression. Therefore, further elucidation network that regulates VHL/HIF-1α pathway will provide potential therapeutic targets for treatment ccRCC. The results current study demonstrated lysosomal-associated protein transmembrane...
Objective To observe the effects of mild hypothermia on post-resuscitation myocardial dysfunction in rabbits order to elucidate underlying mechanism hypothermia.Methods After setting up rabbit model cardiopulmonary resuscitation,20 were randomly ( random number)divided into two groups,namely normothermic resuscitation group (group A,n =10 ) and post-ROSC B,n =10).In A,animals wore treated with standard CPR after cardiac arrest.In group,the body temperature animals was cooled 32 ～ 34°C...