A5100662369- RNA modifications and cancer
- Cancer-related gene regulation
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cancer Immunotherapy and Biomarkers
- Dermatology and Skin Diseases
- Nanoparticle-Based Drug Delivery
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Synthesis and biological activity
- Lung Cancer Treatments and Mutations
- Melanoma and MAPK Pathways
- Cutaneous lymphoproliferative disorders research
- CAR-T cell therapy research
- Nanocomposite Films for Food Packaging
- Cerebrovascular and Carotid Artery Diseases
- Bone and Dental Protein Studies
- Landslides and related hazards
- Hormonal Regulation and Hypertension
- Autoimmune and Inflammatory Disorders Research
- Renin-Angiotensin System Studies
- Immune Cell Function and Interaction
- Medicinal Plants and Bioactive Compounds
- Ferroptosis and cancer prognosis
- ATP Synthase and ATPases Research
- Salivary Gland Disorders and Functions
Tiangong University
2024
Shaanxi University of Chinese Medicine
2024
Gansu Provincial Maternal and Child Health Hospital
2024
Northeast Forestry University
2024
Shangluo University
2024
Xi'an Shiyou University
2024
First Affiliated Hospital of Zhengzhou University
2024
Sun Yat-sen University
2015-2023
Sun Yat-sen University Cancer Center
2015-2023
Zhengzhou University
2023
Summary Background First‐degree relatives ( FDR s) of early‐onset gastric carcinoma EOGC ) patients are at increased risk cancer development. OLGA / OLGIM (Operative Link on Gastritis/Intestinal Metaplasia Assessment) classifications have been proposed for the identification individuals high Aim To estimate prevalence and severity premalignant conditions lesions in s patients. Methods A case–control study was conducted encompassing 103 (cases) 101 age‐ gender‐matched controls, all submitted...
Colorectal cancer (CRC) occurs in the colorectum and ranks second global incidence of all cancers, accounting for one highest mortalities. Although combination chemotherapy regimen 5-fluorouracil (5-FU) platinum(IV) oxaliplatin prodrug (OxPt) is an effective strategy CRC treatment clinical practice, resistance caused by tumor-resided Fusobacterium nucleatum (Fn) could result failure. To enhance efficacy improve biocompatibility chemotherapy, we developed antibacterial-based nanodrug delivery...
Abstract Within a certain range of total transmission ratios, preferred design heavy-duty planetary gear three-stage system, with the volume gearing system as optimization objective, was proposed to address problems such difficulty in coordinating ratios multi-stage challenging balance between lightweight and load-carrying capacity, low space utilization rate. Firstly, based on sequential quadratic programming algorithm, eight kinds ratio preferential assignments were made for system. By...
Pruritus of lymphoma is commonly associated with both Hodgkin (HL) and angioimmunoblastic T cell (AITL) critically affects the life quality patient. Recent evidence suggests that pruritogenic cytokines seem to play a significant role in genesis chronic. This study aims investigate itching patients provide basis for potential therapeutic targets. Serum samples were collected from 60 patients, including 47 13 T-cell (AITL), serving as observation group (lymphoma group, LP n = 60)....
Hepatocellular carcinoma (HCC) accounts for a significant proportion of liver cancer, which has become the second most common cause cancer-related mortality worldwide. To investigate potential mechanisms invasion and progression HCC, bioinformatics analysis validation by qRT-PCR were performed. We found 237 differentially expressed genes (DEGs) including EGR1, FOS, FOSB, three transcription factors. Subsequently, we constructed TF-gene network miRNA-TF-mRNA based on data obtained from mRNA...
Abstract Background Epigenetic abnormalities play important roles in nasopharyngeal cancer (NPC), however, the epigenetic changes associated with abnormal cell proliferation remain unclear. Methods We detected change of ZNF671 NPC tissues and lines by bisulfite pyrosequencing. evaluated zinc finger protein 671 ( ) expression clinical using real-time PCR western blotting. Then, we established that stably overexpressed knocked down to explore its function vitro vivo. Additionally, investigated...
Abstract Purpose: Epigenetic alterations play important roles in metastasis and drug resistance through gene regulation. However, the functional features molecular mechanisms of epigenetic changes remain largely unclear nasopharyngeal carcinoma (NPC) metastasis. Experimental Design: Gene regulatory network analysis was used to identify metastatic-specific dysregulated genes between normal NPC tissues expression validated published Gene-Expression Omnibus data set. The role RAB37...
Background . Cervical squamous cell carcinoma (CSCC) is the main pathological type of cervical cancer, accounting for 80%–85% cancer. Owing to concurrent chemoradiotherapy (CCRT) resistance in a subset CSCC patients, treatment response often unsatisfactory. Identifying predictors and therapeutic targets related cisplatin-based CCRT critical. Methods We reanalyzed GSE56363, an mRNA dataset from GEO database with 21 patients locally advanced CSCC, identify differentially expressed genes (DEGs)...
// Yingqin Li 1, * , Wenfei Qingmei He 1 Yafei Xu Xianyue Ren Xinran Tang Xin Wen Xiaojing Yang Ying Sun Jing Zeng 2 Jingping Yun Na Liu Jun Ma Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, China Department Pathology, These authors contributed equally to this work Correspondence to: Liu, e-mail: liun1@sysucc.org.cn Ma, majun2@mail.sysu.edu.cn Keywords: MET overexpression, amplification, prognosis,...
Allergic asthma is a complex genetic disorder that involves interactions between and environmental factors. Usage of PTEN may be good therapeutic strategy for the management allergic inflammation. Thus, present study aims to explore effects phosphatase tensin homolog (PTEN) gene silencing on airway remodeling proliferation smooth muscle cells (ASMCs) in mouse model asthma.A total 56 healthy female BABL/c mice (weighing 16 22 grams) were selected assigned random into ovalbumin (OVA;...
Background Ovarian cancer is the most lethal type of malignant tumor in gynecological cancers and associated with a high percentage late diagnosis chemotherapy resistance. Thus, it urgent to identify marker or molecular target that allows early detection effective treatment. RNA-binding proteins (RBPs) are crucial various cellular processes at post-transcriptional level. The eukaryotic translation initiation factor 4 gamma, 1(eIF4G1), an protein, facilitates recruitment mRNA ribosome, which...
Increasing evidence recognizes that DNA methylation abnormalities play critical roles in cancer development. Our previous genome-wide profile showed tumor necrosis factor-alpha-induced protein 8 like 3 (TIPE3) was hypermethylated nasopharyngeal carcinoma (NPC). However, the relationship between TIPE3 and its mRNA expression, as well biological NPC are unknown. Bisulfite pyrosequencing quantitative RT-PCR were performed to quantify expression levels. Kaplan-Meier curves Cox regression...
DNA methylation is an important epigenetic change in carcinogenesis. However, the function and mechanism of dysregulation nasopharyngeal carcinoma (NPC) still largely unclear. Our previous genome-wide microarray data showed that NFAT1 one most hypermethylated transcription factor genes NPC tissues. Here, we found hypermethylation contributes to its down-regulation NPC. overexpression inhibited cell migration, invasion, epithelial-mesenchymal transition vitro tumor metastasis vivo. We further...
The use of edible packaging films to delay food spoilage has attracted widespread attention. In this study, partridge tea extract (PTE) was added cassia gum (CG) prepare CG/PTE films. microstructure, optical, mechanical, barrier, and antioxidant properties were investigated, the effect PTE on CG shown. had high transparency smooth surface structure. Additionally, significantly improved elongation at break activity At 2.5% PTE, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging rate film...
Introduction Cynaroside exhibits various biological properties, including anti-inflammatory, antiviral, antitumor, and cardioprotective effects. However, its involvement in methotrexate (MTX)-induced intestinal inflammation remains inadequately understood. Thus, we investigated the impact of cynaroside on MTX-induced potential mechanisms. Methods To assess protective against inflammation, Sprague-Dawley rats were subjected to a regimen 7 mg/kg MTX for 3 days, followed by treatment with at...
Alternative polyadenylation (APA) is a widespread phenomenon in the posttranscriptional regulation of gene expression that generates mRNAs with alternative 3'-untranslated regions (3'UTRs). APA contributes to pathogenesis various diseases, including cancer. However, potential role development nasopharyngeal carcinoma (NPC) remains largely unknown.A strategy sequencing sites (SAPAS) based on second-generation technology was carried out explore global patterns and identify genes tandem 3'UTRs...
A sensitive, convenient, rapid and economic liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed to determine cinacalcet concentration in human plasma. stable isotope (cinacalcet-D3) selected as internal standard the analytes were extracted from plasma samples by a one-step precipitation procedure. Chromatography separation conducted on an Eclipse Plus C18 column gradient elution with mobile phase of methanol-water-ammonium formate system at constant flow rate 0.6...
Heart failure (HF) is the final stage of heart disease. An increasing number experiments and clinical reports have shown that traditional Chinese medicine (TCM) has many therapeutic effects advantages in treating HF. In this study, we used bioinformatics methods to screen key genes predict components herbal medicines with preventive on GSE120895 GSE21610 HF chips were downloaded from Gene Expression Omnibus database. We screened differentially expressed (DEGs). Weighted gene coexpression...
Endosomal pH-responsive micellar nanoparticles were prepared by self-assembly of amphiphilic polyethylene glycol-Schiff base bond-doxorubicin (PEG-Schiff-DOX) prodrug prodrugs, and free DOX can be encapsulated within the hydrophobic cores nanoparticles. These exhibited excellent storage stability under normal conditions for more than a week but rapidly disassembled in slightly acidic environment. The loading nanoparticle up to 61%. CCK-8 assay showed that better antitumor activity against...
Angioleiomyoma (ALM) is a rare benign perivascular (pericytic) tumor primarily composed of well-differentiated smooth muscle and vascular components. Its clinical radiological features lack specificity, making diagnosis challenging prone to misdiagnosis. This report summarizes the data patient treated at our hospital who was preoperatively misdiagnosed with rectal cancer but subsequently found have perirectal ALM. Additionally, review relevant literature provided.