A5013900870- Cancer-related gene regulation
- Cancer Immunotherapy and Biomarkers
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Head and Neck Cancer Studies
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Wnt/β-catenin signaling in development and cancer
- Endometrial and Cervical Cancer Treatments
- Kruppel-like factors research
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Histone Deacetylase Inhibitors Research
- Head and Neck Surgical Oncology
- Circular RNAs in diseases
- Ear and Head Tumors
- Fibroblast Growth Factor Research
- RNA Research and Splicing
- Coronary Interventions and Diagnostics
- Cardiac Ischemia and Reperfusion
- Video Analysis and Summarization
Nanfang Hospital
2019-2025
Southern Medical University
2019-2025
Sanming University
2024
Ruijin Hospital
2023
Shandong First Medical University
2023
Shandong Tumor Hospital
2023
Sun Yat-sen University
2015-2021
Sun Yat-sen University Cancer Center
2015-2021
State Key Laboratory of Oncology in South China
2015-2021
Third Affiliated Hospital of Sun Yat-sen University
2015-2020
Although tumor mutation burden (TMB) has been well known to predict the response immune checkpoint inhibitors (ICI), lack of randomized clinical trial data restricted its application. This study aimed explore significance and feasibility biomarker combination based on TMB copy-number alteration (CNA) for prognosis each prediction ICI therapy in metastatic pan-cancer milieu.Non-ICI-treated MSK cohort was used analysis. Three independent immunotherapy cohorts, including non-small cell lung...
Nasopharyngeal carcinoma (NPC) is characterized by a high rate of local invasion and early distant metastasis. Increasing evidence indicates that epigenetic abnormalities play important roles in NPC development. However, the mechanisms underlying metastasis remain unclear. Here we investigate aberrantly methylated transcription factors tissues, identify HOP homeobox HOPX as most significantly hypermethylated gene. Consistently, find HOXP expression downregulated tissues cell lines. Restoring...
Liver kinase B1 (LKB1) mutation is prevalent and a driver of resistance to immune checkpoint blockade (ICB) therapy for lung adenocarcinoma. Here leveraging single cell RNA sequencing data, we demonstrate that trafficking adhesion process activated T cells are defected in genetically engineered Kras-driven mouse model with Lkb1 conditional knockout. LKB1 mutant cancer result marked suppression intercellular molecule-1 (ICAM1). Ectopic expression Icam1 Lkb1-deficient tumor increases homing...
The therapeutic strategy for advanced nasopharyngeal carcinoma (NPC) is still challenging. It an urgent need to uncover novel treatment targets NPC. Therefore, understanding the mechanisms underlying NPC tumorigenesis and progression essential development of new strategies. Here, we showed that TP53-regulated inhibitor apoptosis (TRIAP1) was aberrantly overexpressed associated with poor survival in patients. TRIAP1 overexpression promoted cell proliferation suppressed death vitro vivo,...
// Qingmei He 1, * , Xianyue Ren Jiewei Chen Yingqin Li 1 Xinran Tang Xin Wen Xiaojing Yang Jian Zhang Yaqin Wang Jun Ma Na Liu Sun Yat-Sen University Cancer Center, State Key laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, People’s Republic China These authors contributed equally to this work Correspondence to: Liu, e-mail: liun1@sysucc.org.cn Keywords: miR-16, fibroblast growth factor 2, nasopharyngeal carcinoma, tumor growth, metastasis...
Abstract Clinically, distant metastasis after primary treatment remains a key problem in nasopharyngeal carcinoma (NPC), and the outcome of metastatic NPC disappointing, so there is pressing need to identify novel therapeutic strategies. In accordance with our previous microarray data, we found that miR-101 was downregulated clinical specimens cell lines. Ectopic expression significantly suppressed migration, invasion angiogenesis vitro inhibited vivo using chicken chorioallantoic membrane...
Background Genetic variations of some driver genes in non-small cell lung cancer (NSCLC) had shown potential impact on immune microenvironment and associated with response or resistance to programmed death protein 1 (PD-1) blockade immunotherapy. We therefore undertook an exploratory analysis develop a genomic mutation signature (GMS) predict the anti-PD-(L)1 therapy. Methods In this multicohort analysis, 316 patients non-squamous NSCLC treated from three independent cohorts were included...
Although metabolic syndrome (MetS) is associated with an increased risk of various cancers, the combined impact MetS and healthy lifestyle factors (HLF) on cancer unclear. This study aimed to investigate independent effects HLF 16 site-specific cancers in a large community-based cohort. A total 289,557 participants UK Biobank were analyzed. was defined using combination factors, while scores evaluated based behaviors, such as smoking, alcohol consumption, physical activity, diet. Cox...
Metastasis remains the major cause of death in nasopharyngeal carcinoma (NPC). Yippee-like 3 (YPEL3) plays an important role tumorigenesis. However, its function and mechanism NPC has not been systematically explored.We evaluated YPEL3 expression cell lines tissues using real-time PCR western blotting. Then, we established that stably overexpressed knocked down to explore vitro vivo. Additionally, investigated potential action by identifying Wnt/β-catenin signaling pathway downstream genes...
Abstract Altered DNA methylation is a key feature of cancer, and aberrant important in nasopharyngeal carcinoma (NPC) development. However, the mechanisms underlying metastasis NPC remain unclear. Analyzing data from public databases conducting our own experiments, we report here that promoter hypermethylation SHISA3 common contributes to downregulation this gene many types tumors, including NPC. suppressed cell invasion vitro vivo by impeding E3 ubiquitin ligase tripartite motif containing...
Distant metastasis remains the predominant mode of treatment failure in nasopharyngeal carcinoma (NPC). Unfortunately, molecular events underlying NPC remain poorly understood. Secreted frizzled-related protein 1 (SFRP1) plays an important role tumorigenesis and progression. However, little is known about function mechanism SFRP1 NPC. Immunohistochemistry was used to determine expression levels patients with evaluated using MTT, colony formation, wound-healing, Transwell assays, vivo models....
Increasing evidence has demonstrated a significant role for long non-coding RNAs (lncRNAs) in tumorigenesis. However, their functions nasopharyngeal carcinoma (NPC) metastasis remain largely unknown. In this study, model comparing high and low metastatic NPC cell lines (5-8F vs. 6-10B S18 S26) was constructed to determine the expression profile of lncRNAs using microarray analysis, we found 167 209 mRNAs were differentially expressed. Bioinformatic analysis indicated that dysregulated...
Abstract Background Immune checkpoint inhibitor (ICI) therapy combined with conventional therapies is being broadly applied in non-small cell lung cancer (NSCLC) patients. However, the risk of interstitial pneumonitis (IP) following a regimen incompletely characterized. Methods A total 46,127 NSCLC patients were extracted for disproportionality analyses IP from Food and Drug Administration’s Adverse Event Reporting System (FAERS) database. 1108 who received ICI treatment at Nanfang Hospital...
Abstract Background Epigenetic abnormalities play important roles in nasopharyngeal cancer (NPC), however, the epigenetic changes associated with abnormal cell proliferation remain unclear. Methods We detected change of ZNF671 NPC tissues and lines by bisulfite pyrosequencing. evaluated zinc finger protein 671 ( ) expression clinical using real-time PCR western blotting. Then, we established that stably overexpressed knocked down to explore its function vitro vivo. Additionally, investigated...
Abstract Purpose: Epigenetic alterations play important roles in metastasis and drug resistance through gene regulation. However, the functional features molecular mechanisms of epigenetic changes remain largely unclear nasopharyngeal carcinoma (NPC) metastasis. Experimental Design: Gene regulatory network analysis was used to identify metastatic-specific dysregulated genes between normal NPC tissues expression validated published Gene-Expression Omnibus data set. The role RAB37...
ADME genes are a set of which involved in drug absorption, distribution, metabolism, and excretion (ADME). However, prognostic value function head neck squamous cell carcinoma (HNSCC) remain largely unclear. In this study, we established an ADME-related model through the least absolute shrinkage selection operator (LASSO) analysis Cancer Genome Atla (TCGA) training cohort its robustness was validated by TCGA internal validation Gene Expression Omnibus (GEO) external cohort. The 14-gene...
Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis several malignant tumors. The aim of this study was to evaluate the expression prognostic value nasopharyngeal carcinoma (NPC).Talin-1 mRNA were examined NPC cell lines clinical tissues by quantitative RT-PCR, agarose gel electrophoresis western blotting. analyzed immunohistochemical staining 233 paraffin-embedded specimens with follow-up data cox regression analysis used identify...
// Yingqin Li 1, * , Wenfei Qingmei He 1 Yafei Xu Xianyue Ren Xinran Tang Xin Wen Xiaojing Yang Ying Sun Jing Zeng 2 Jingping Yun Na Liu Jun Ma Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center Medicine, Guangzhou, China Department Pathology, These authors contributed equally to this work Correspondence to: Liu, e-mail: liun1@sysucc.org.cn Ma, majun2@mail.sysu.edu.cn Keywords: MET overexpression, amplification, prognosis,...