A5041232175- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Coronary Interventions and Diagnostics
- Atrial Fibrillation Management and Outcomes
- Cardiac pacing and defibrillation studies
- Lipoproteins and Cardiovascular Health
- Laser Applications in Dentistry and Medicine
- Cancer Immunotherapy and Biomarkers
- Cardiovascular Function and Risk Factors
- Venous Thromboembolism Diagnosis and Management
- Cancer-related molecular mechanisms research
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Arrest and Resuscitation
- Cardiovascular Disease and Adiposity
- Cardiac Arrhythmias and Treatments
- Circular RNAs in diseases
- Vasculitis and related conditions
- Cardiovascular Health and Risk Factors
- Forensic and Genetic Research
- Colorectal and Anal Carcinomas
- Selenium in Biological Systems
- Cholesterol and Lipid Metabolism
- Cardiac Fibrosis and Remodeling
- Atherosclerosis and Cardiovascular Diseases
- Biomarkers in Disease Mechanisms
Sun Yat-sen Memorial Hospital
2022-2025
Sun Yat-sen University
2022-2025
Dalian Medical University
2025
Beijing Anzhen Hospital
2014-2024
Capital Medical University
2000-2024
Beijing Children’s Hospital
2024
Southern Medical University
2023
Shandong University of Technology
2023
Chongqing Medical University
2021-2023
Fudan University
2021
Liver kinase B1 (LKB1) mutation is prevalent and a driver of resistance to immune checkpoint blockade (ICB) therapy for lung adenocarcinoma. Here leveraging single cell RNA sequencing data, we demonstrate that trafficking adhesion process activated T cells are defected in genetically engineered Kras-driven mouse model with Lkb1 conditional knockout. LKB1 mutant cancer result marked suppression intercellular molecule-1 (ICAM1). Ectopic expression Icam1 Lkb1-deficient tumor increases homing...
BACKGROUND The incidence of colon cancer has been progressively increasing over time, whereas penile metastasis remained exceedingly uncommon. Since the prognosis for with BRAF V600E mutation is relatively unfavorable, further exploration and investigation are still required to develop treatment strategies such rare cases. CASE SUMMARY About one year after surgery chemotherapy, a 50-year-old patient sigmoid developed mass at base patient's penis, accompanied by severe tenderness pain during...
Abstract Introduction Neuroendocrine differentiation (NED) in colorectal cancer (CRC) cells has been known for decades, and our previous meta-analysis indicated that CRC patients with neuroendocrine have a lower 5-year survival rate. In recent years, an increasing number of studies found exosome-derived long non-coding RNAs (lncRNAs) play important roles progression metastasis. However, the functions mechanism lncRNAs are not yet fully clear. Materials methods The clinical significance NED...
To investigate the effects of cellular membrane connexin 43 (Cx43) and potential details in ischemic postconditioning (IPOC)‑induced cardioprotection, ischemia/reperfusion (IR) models were generated 8‑week‑old male Sprague‑Dawley rats by ligating left coronary artery anterior descending branch. The serum levels myocardial creatases, nitric oxide (NO) malondialdehyde (MDA) levels, infarct size, arrhythmia events, expression distribution Cx43, ultrastructure apoptosis myocardium different...
The aim of the study was to evaluate feasibility and operative outcomes anterior approach technique for a simultaneous colorectal liver laparoscopic procedure given its demonstrated benefits discuss advantages this strategy.In presented case, total used left hemihepatectomy in combination with resections synchronous metastases, which emphasizes technical aspects procedure. duration surgery, blood loss, postoperative were evaluated.The hepatectomy colon resection metastases feasible safe...
Familial hypercholesterolemia (FH) is an important cause of premature coronary artery disease (CAD). Prognosis data are lacking in patients with FH and particularly the era widespread statin use. We compared long-term prognosis between without after a event.
Abstract Background: The detrimental outcomes of right ventricular pacing on left electromechanical function ultimately result in heart failure, a phenomenon termed pacing-induced cardiomyopathy (PICM) clinical research. This study aimed to validate prognostic factors that can be used identify patients with higher susceptibility progress the stage before pacemaker implantation. Methods: observational analysis enrolled 256 between January 2013 and June 2016, 23 (8.98%) whom progressed PICM...
Congenital heart disease (CHD) is the most common cause of congenital anomaly and a leading morbidity mortality worldwide. Generation cardiomyoctyes derived from pluripotent stem cells (PSCs) has opened new avenues for investigation human cardiac development. Here we report that uric acid (UA), physiologically abundant compound during embryonic development, can consistently robustly enhance differentiation PSCs including hESCs hiPSCs, in replacement ascorbic (AA). We optimized treatment...
Objective: To assess the expanding needs on lipid-lowering treatment in patients with acute coronary syndrome (ACS) by applying newly issued definition of extreme high-risk, which is proposed Chinese expert consensus lipid management high-risk atherosclerotic cardiovascular disease (ASCVD) Society Cardiology (CSC). Methods: Data this study was derived from Improving Care for Cardiovascular Disease China (CCC) project, a case-based nationwide registry and launched as collaborative initiative...
To investigate the efficacy and safety of stent versus non-stent in treating acute ST-segment elevation myocardial infarction (STEMI) patients with single vessel disease intermediate stenosis culprit lesions.
Epigenetic changes of lung adenocarcinoma (LUAD) have been reported to be a relevant factor in tumorigenesis and cancer progression. However, the molecular mechanisms responsible for DNA methylation patterns tumor immune-infiltrating microenvironment immunotherapy remain unclear.We conducted global analysis modification pattern (DMP) immune cell-infiltrating characteristics LUAD patients based on 21 regulators. A score (DMS) system was constructed quantify DMP model each patient estimate...
Hypoxemia sometimes occurs in the emergency room patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), even those administration of conventional high-flow oxygen inhalation. The objective present study was to evaluate effectiveness non-invasive ventilation (NIV) improving blood content and hemorheology AMI hypoxemia.This prospective enrolled 50 consecutive eligible (aged 72.3 ± 9.5 years), who had undergone PCI been administered but still hypoxemia....
Objective: To investigate the association between smoking and severity of coronary lesions among young middle-aged female patients with acute syndrome (ACS). Methods: Data this study were derived from Improving Care for Cardiovascular Disease in China (CCC)-ACS project, a collaborative Chinese Society Cardiology American Heart Association. Since 2014, CCC-ACS project consecutively enrolled inpatients ACS, systematically collected their clinical data evaluated medical quality these 158...
Smith-Lemli-Opitz syndrome is a birth defect caused by the deficiency of 7-dehydrocholesterol reductase in cholesterol biosynthesis pathway, which leads to accumulation and reduction body fluids. To effectively diagnose monitor therapy, reliable method for simultaneous detection needed.In presence antioxidants (2,6-ditert-butyl-4-methylphenol triphenylphosphine), 50 μL human plasma were hydrolyzed at 70℃ 40 min with 1 M potassium hydroxide 90% ethanol, then extracted 600 n-hexane three...
To analyze the clinical characteristics of patients with common cardiovascular diseases (CVD, including hypertension, coronary heart disease, atrial fibrillation, and failure) combined mild cognitive impairment (MCI) explore potential risk factors MCI in CVD.
Background: The global demand for pediatric caries treatment under general anesthesia (PCTGA) has been increasing, driven by the rising incidence of dental in young children and adolescents challenges posed non-cooperative patients. This study aimed to examine epidemiological features disease burden PCTGA China during COVID-19 pandemic. Methods: Data were collected from medical record discharge summaries patients admitted three children’s hospitals affiliated with Futang Research Center...
The benefit/risk ratio of stenting in acute ST-segment elevation myocardial infarction (STEMI) patients with single vessel intermediate stenosis culprit lesions merits further study, therefore the subject present study.It was a prospective, multicenter, randomized controlled trial. Between April 2012 and July 2015, 399 STEMI disease (40%-70%) lesion before or after aspiration thrombectomy and/or intracoronary tirofiban (15 µg/kg) were enrolled randomly assigned (1: 1) to group (n = 201)...