A5070487819- Hearing, Cochlea, Tinnitus, Genetics
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Hearing Loss and Rehabilitation
- Vestibular and auditory disorders
- Eating Disorders and Behaviors
- Spinal Cord Injury Research
- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neural dynamics and brain function
- Traumatic Brain Injury Research
- Neurological Disease Mechanisms and Treatments
- Advanced MRI Techniques and Applications
- Domain Adaptation and Few-Shot Learning
- Cardiac Ischemia and Reperfusion
- Neuroscience and Music Perception
- Neural and Behavioral Psychology Studies
- Dialysis and Renal Disease Management
- Neurological Disorders and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Obsessive-Compulsive Spectrum Disorders
- Transcranial Magnetic Stimulation Studies
- Neonatal and fetal brain pathology
- Pediatric health and respiratory diseases
- EEG and Brain-Computer Interfaces
Capital Medical University
2017-2025
Beijing Friendship Hospital
2019-2025
Fujian Medical University
2024-2025
Fujian Provincial Hospital
2020-2025
Third Affiliated Hospital of Guangzhou Medical University
2024-2025
Philadelphia College of Osteopathic Medicine
2022-2024
University of California, Santa Cruz
2022-2024
Beijing Anzhen Hospital
2024
Kunming Medical University
2024
Shenzhen Bao'an District People's Hospital
2024
Inflammation and apoptosis play critical roles in the acute progression of ischemic injury pathology. Emerging evidence indicates that vagus nerve stimulation (VNS) following focal cerebral ischemia reperfusion (I/R) may be neuroprotective by limiting infarct size. However, underlying molecular mechanisms remain unclear. In this study, we investigated whether protective effects VNS I/R were associated with anti-inflammatory anti-apoptotic processes. Male Sprague-Dawley (SD) rats underwent at...
Background: The cumulative effect of body mass index (BMI) on brain health remains ill-defined. effects overweight across different age groups need clarification. We analyzed the BMI neuroimaging features in adults ages. Methods: This study was based a multicenter, community-based cohort study. modeled trajectories over 16 years to evaluate exposure. Multimodality data were collected once for volumetric measurements macrostructure, white matter hyperintensity (WMH), and microstructure. used...
Abstract Purpose To develop and validate an integrated model for discriminating tumor recurrence from radiation necrosis in glioma patients. Methods Data 160 pathologically confirmed patients were analyzed. The diagnostic was developed a primary cohort ( n = 112). Textural features extracted postoperative 18 F-fluorodeoxyglucose F-FDG) positron emission tomography (PET), 11 C-methionine C-MET) PET, magnetic resonance images. least absolute shrinkage selection operator regression used feature...
Epilepsy is a chronic neurologic disorder characterized by abnormal functioning of brain networks, making it complex research topic. Recent advancements in neuroimaging technology offer an effective approach to unraveling the intricacies human brain. Within different types epilepsy, there growing recognition regarding ongoing changes default mode network (DMN). However, little known about shared and distinct alterations static functional connectivity (sFC) dynamic (dFC) DMN among epileptic...
The aim of this study was to explore possible changes in whole brain gray matter volume (GMV) after spinal cord injury (SCI) using voxel-based morphometry (VBM), and their associations with the duration, severity, clinical variables. In total, 21 patients SCI (10 complete 11 incomplete SCI) age- sex-matched healthy controls (HCs) were recruited. 3D high-resolution T1-weighted structural images all subjects obtained a 3.0 Tesla MRI system. Disease duration American Spinal Injury Association...
Abstract Topological properties, which serve as the core of neural network, and their couplings can reflect different therapeutic effects in tinnitus patients. We hypothesized that patients with outcomes after sound therapy (narrowband noise) would have distinct brain network topological alterations. Diffusion tensor imaging resting‐state functional magnetic resonance (fMRI) were prospectively performed 60 idiopathic 57 healthy controls (HCs). Graph‐theoretical analyses structural...
We cloned two novel human transmembrane semaphorins, (HSA)SEMA6C and (HSA)SEMA6D, that belong to the class VI subgroup of semaphorin family. The genes for SEMA6C SEMA6D are mapped on chromosome 1q12–21.1 15q21.1, respectively. Among adult tissues, is expressed only in skeletal muscle, whereas abundantly kidney, brain, placenta moderately heart muscles. During murine development, neither nor was embryonic day 10.5 (E10.5) embryos, but both were highly areas lateral ventricle, striatum, wall...
Abstract Background Previous studies found minimal evidence and raised controversy about the link between hemoglobin 28-day mortality in sepsis patients. As a result, purpose of this study was to examine association death patients by analyzing Medical Intensive Care IV (MIMIC-IV) database from 2008 2019 at an advanced medical center Boston, Massachusetts. Methods We extracted 34,916 MIMIC-IV retrospective cohort database, using as exposure variable outcome variable, after adjusting for...
Patients with end stage CKD often develop cognitive decline, but whether this is related to the underlying disease or hemodialysis remains unclear. We performed three-dimensional pseudocontinuous arterial spin labeling and quantitative susceptibility mapping prospectively in 40 patients 1-4 CKD, 47 nondialysis 5 44 healthy controls. Our magnetic resonance imaging data demonstrate that changes cerebral blood flow-susceptibility coupling might underlie perhaps hippocampus thalamus. These...
It remains unknown whether tinnitus or tinnitus-related hearing loss (HL) could indirectly impair reshape the white matter (WM) of human brain. We aim to explore possible brain WM change in patients without HL, further investigate their associations with clinical variables. Structural and diffusion tensor imaging (DTI) 20 idiopathic HL 22 healthy controls (HCs) were obtained. Voxel-based morphometry (VBM) tract-based spatial statistics (TBSS) analysis conducted differences volume integrity...
Objective To examine the association between circadian locomotor output cycles kaput ( CLOCK) gene rs1554483 G/C polymorphism and susceptibility to Alzheimer's disease in Chinese people. Methods This case–control study determined apolipoprotein E APOE) CLOCK genotypes using polymerase chain reaction restriction fragment length polymorphism. Results Unrelated patients with n = 130) healthy controls 188) were analysed for an disease. In whole sample APOE ɛ4 isoform noncarriers, prevalence of G...
To determine the neural mechanism underlying effects of sound therapy on tinnitus, we hypothesize that may be effective by modulating both local activity and functional connectivity is associated with auditory perception, information storage or emotional processing. In this prospective observational study, 30 tinnitus patients underwent resting-state magnetic resonance imaging scans at baseline after 12 weeks therapy. Thirty-two age- gender-matched healthy controls also two over a 12-week...
<h3>BACKGROUND AND PURPOSE:</h3> Currently, there is no effective treatment for pediatric patients with complete spinal cord injury. Motor imagery has been proposed as an alternative to physical training who are unable move voluntarily. Our aim was reveal the potential mechanism of motor in rehabilitation <h3>MATERIALS METHODS:</h3> Twenty-six injury and 26 age- sex-matched healthy children controls were recruited. All participants underwent task-related fMRI scans, additional execution...
High myopia (HM) is a public health issue that can lead to severe visual impairment. Previous studies have exhibited widespread white matter (WM) integrity damage in HM patients. However, how these WM damages are topologically related, and the network-level structural disruptions underlying has not been fully defined. We aimed assess alterations of brain networks patients using diffusion kurtosis imaging (DKI) tractography present study. Individual whole-brain ROI-level were constructed DKI...
Abstract Background Bulimia nervosa (BN) is an eating disorder characterized by recurrent binge and compensatory behaviors. The thalamus plays a crucial role in the neural circuitry related to behavior needs be further explored BN. Methods In this study, 49 BN patients 44 healthy controls (HCs) were recruited. We applied fractional amplitude of low-frequency fluctuation investigate regional brain activity functional connectivity (FC) examine synchronization between thalamic subregions other...