A5100400653- Cancer Research and Treatments
- Eating Disorders and Behaviors
- Extracellular vesicles in disease
- Cancer, Hypoxia, and Metabolism
- Functional Brain Connectivity Studies
- Ubiquitin and proteasome pathways
- Endoplasmic Reticulum Stress and Disease
- HIV-related health complications and treatments
- Neural and Behavioral Psychology Studies
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Autophagy in Disease and Therapy
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Ovarian cancer diagnosis and treatment
- Liver Diseases and Immunity
- Pediatric Hepatobiliary Diseases and Treatments
- Cardiovascular Disease and Adiposity
- Obsessive-Compulsive Spectrum Disorders
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Peroxisome Proliferator-Activated Receptors
- HIV Research and Treatment
- RNA Interference and Gene Delivery
- Single-cell and spatial transcriptomics
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2025
Capital Medical University
2017-2024
Beijing YouAn Hospital
2008-2024
Beijing Friendship Hospital
2022-2024
Shenzhen Second People's Hospital
2024
Shenzhen University Health Science Center
2024
Beijing Anding Hospital
2023
Chinese Institute for Brain Research
2023
Institute of Psychology, Chinese Academy of Sciences
2023
Beijing Institute of Neurosurgery
2018-2022
The ATP-gated P2X7 has been shown to play an important role in invasiveness and metastasis of some tumors. However, the possible links underlying mechanisms between prostate cancer have not elucidated. Here, we demonstrated that was highly expressed cells. Down-regulation by siRNA significantly attenuated ATP- or BzATP-driven migration invasion cells vitro, inhibited tumor metastases nude mice. In addition, silencing remarkably BzATP- driven expression changes EMT/invasion-related genes...
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of targeted agents for the treatment solid tumors. Concurrent PARP inhibition in Breast Cancer Susceptibility Gene (BRCA)-mutated or homologous recombination-deficient tumor cells can induce "synthetic lethality", which targets two DNA repair pathways and induces serious cytotoxicity to without damaging normal cells. Currently, such as olaparib, rucaparib niraparib, improve progression-free survival, particularly patients...
Recent studies in cognitively unimpaired elderly individuals suggest that the APOE ε4 allele exerts a dosage-dependent effect on brain tau deposition. The aim of this study was to investigate sex differences gene dosage effects deposition impaired using quantitative 18F-flortaucipir PET. Preprocessed PET images, T1-weighted structural MRI, demographic information, global cortical amyloid-β burden measured by 18F-florbetapir PET, CSF total and phosphorylated measurements were obtained from...
Abstract Purpose: Patients with recurrent or metastatic sinonasal squamous cell carcinoma (R/M SNSCC) lack standardized systemic treatment and prospective studies. We evaluated the anti-tumor response safety of pembrolizumab nab-paclitaxel platinum in R/M SNSCC. Methods: SNSCC patients received 200mg, 260mg/m2 plus cisplatin 75 mg/m2 carboplatin at an area under curve 5 on day 1 every 21 days for up to six cycles, followed by maintenance until progression unacceptable toxicity 35 cycles. The...
Hepatic metastasis is responsible for the majority of colorectal cancer (CRC)-related mortalities. Although Gankyrin (PSMD10) has been implicated in metastasis, its exact role and underlying mechanisms CRC hepatic remain largely unknown. Herein, we showed that expression was higher primary with compared without metastasis. RNAi-mediated silencing highly metastatic human cells impaired their migratory capacity vivo. Genome-wide transcriptome profiling revealed activation interleukin (IL)-8...
Stearoyl-CoA desaturase 1 (SCD1) is an established molecular target in many primary tumors including breast, lung, pancreatic, colon and hepatocellular carcinomas. However, its potential role supporting endometrial cancer growth progression has not yet been determined. In this study, we evaluated the value of SCD1 as a candidate therapeutic human cancer. Compared with secretory post-menopausal endometrium, was highly expressed normal endometrium proliferative phase, hyperplasia carcinoma,...
Resting-state functional magnetic resonance imaging (fMRI) studies have demonstrated that basal ganglia connectivity is altered in Parkinson's disease (PD) as compared to healthy controls. However, such alterations not been related the dopaminergic deficits occurs PD over time. To examine whether impairments are correlated with across subdivisions patients both cross-sectionally and longitudinally. We assessed resting-state of dopamine transporter density using 11C-PE2I PET thirty-four at...
Abstract Background Bulimia nervosa (BN) is an eating disorder characterized by recurrent binge and compensatory behaviors. The thalamus plays a crucial role in the neural circuitry related to behavior needs be further explored BN. Methods In this study, 49 BN patients 44 healthy controls (HCs) were recruited. We applied fractional amplitude of low-frequency fluctuation investigate regional brain activity functional connectivity (FC) examine synchronization between thalamic subregions other...
Abstract Endoplasmic reticulum stress (ER stress) just like a double-edged sword depending on different conditions in the development of multiple hepatic diseases. But molecular mechanisms functional conversion during ER have not been fully elucidated. In this study, we aim to illustrate role PPARα and subtle mechanism stress. Tunicamycin (TM) thapsigargin (TG), as inducers, were used induce AML12 cells. During stress, qRT-PCR immunoblotting was measure expression levels GRP78 CHOP which...
Exosomes are nanoscale vesicles released by diverse types of cells for complex intercellular communication. Numerous studies have shown that exosomes can regulate the body's immune response to tumor and interfere with microenvironment (TME). In clinical trials on dendritic cell (DC)-based antitumor vaccines, no satisfactory results been achieved. However, recent suggested DC-derived (DEX) may be superior DC-based vaccines in avoiding tumor-cell-mediated immunosuppression. DEX...
Patients with human immunodeficiency virus (HIV) are at a significantly higher risk of cardiovascular disease (CVD) compared to HIV-negative people. Left heart dysfunction is the most common cardiac complication in people living HIV/acquired immune deficiency syndrome (PLWHA), and diastolic an important predictor events. The aims this study were (1) detect changes left structure function antiretroviral therapy (ART)-naive PLWHA using echocardiography; (2) investigate factors for development...
Alzheimer's disease (AD) is a progressive neurodegenerative characterized by cognitive decline and memory impairment. Amnestic mild impairment (aMCI) the intermediate stage between normal aging early dementia caused AD. It can be challenging to differentiate aMCI patients from healthy controls (HC) AD patients.To validate whether combination of 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) diffusion tensor imaging (DTI) will improve classification performance compared...
Familial partial lipodystrophy type 3 (FPLD3) is an autosomal dominant disease. Patients typically present with loss of adipose tissue and metabolic complications. Here, we reported a Chinese FPLD3 patient novel PPARG gene mutation.A 16-year-old female her relatives were assessed by detailed clinical biochemical examinations. Sequencing was performed using the extracted DNA. Moreover, identified patients from previous studies, according to protein region affected mutation. We divided into...
Abstract Bulimia nervosa (BN) has been observationally linked to the functional connectivity (FC) of large-scale brain networks, but biological mechanisms remain unclear. This study used two-sample Mendelian randomization (MR) with genetic variations as instrumental variables (IVs) explore potential causal relationships between FC and BN. Summary data from genome-wide association studies (GWAS) involving 2,564 individuals were analyzed identify genetically predicted Functional magnetic...
Brain structural and functional abnormalities have been shown to be involved in the neurobiological underpinnings of bulimia nervosa (BN), while mechanisms underlying this dysregulation are unclear. The main goal investigation was explore presence brain alterations relevant changes BN. We hypothesized that BN patients had regional gray matter volume corresponding resting-state connectivity (rsFC) compared with healthy controls. Thirty-one twenty-eight matched controls underwent both...