A5100389552- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- PARP inhibition in cancer therapy
- Toxin Mechanisms and Immunotoxins
- Effects of Radiation Exposure
- Management of metastatic bone disease
- CRISPR and Genetic Engineering
- Sphingolipid Metabolism and Signaling
- Pregnancy-related medical research
- Pelvic floor disorders treatments
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Cervical Cancer and HPV Research
- Cancer-related Molecular Pathways
- Antioxidant Activity and Oxidative Stress
- Anorectal Disease Treatments and Outcomes
- Estrogen and related hormone effects
- Cancer, Hypoxia, and Metabolism
- Retinoids in leukemia and cellular processes
- Cell death mechanisms and regulation
- Metabolism, Diabetes, and Cancer
- Cancer and Skin Lesions
- Caveolin-1 and cellular processes
The First People's Hospital of Changde
2025
Central South University
2025
University of California, Los Angeles
2024
Beijing Chao-Yang Hospital
2016-2019
Capital Medical University
2016-2019
Beijing Chaoyang Emergency Medical Center
2018
Abstract: Poly (ADP-ribose) polymerase (PARP) inhibitors are a class of targeted agents for the treatment solid tumors. Concurrent PARP inhibition in Breast Cancer Susceptibility Gene (BRCA)-mutated or homologous recombination-deficient tumor cells can induce "synthetic lethality", which targets two DNA repair pathways and induces serious cytotoxicity to without damaging normal cells. Currently, such as olaparib, rucaparib niraparib, improve progression-free survival, particularly patients...
Obesity has been linked to several types of cancers including ovarian cancer. Retinol binding protein 4 (RBP4) is an adipokine that drives the development hyperinsulinemia and type II diabetes in obesity patients animals. Previously, we have identified RBP4 as a serum marker for Here further explored consequence upregulation cancer cells its molecular mechanism. Our results show overexpressed same extent adipose tissues. The overexpression promotes cell migration proliferation. At level,...
Adaptive radiotherapy (ART) provides greater benefits than intensity-modulated (IMRT) regarding dosimetric outcomes in patients with cervical cancer. To investigate the clinical of ART, we have collected data from 115 cancer who underwent radical at our institution. Fifty-nine received a single course IMRT. Fifty-six offline defined as reduction gross tumor volume (GTV) by least 30% after 30 Gy radiotherapy, followed modified treatment plan for second-stage. After treatment, 53 ART group...
To determine the effect of mechanical stretching load and efficacy postmenopausal estrogen therapy (ET) on pelvic organ prolapse (POP), vaginal fibroblasts isolated from women with or without POP were subjected to 0.1-Hz uniaxial cyclic (CS) 10% elongation 10−8 M 17-β-estradiol (E2) treatment. We investigated morphological characteristics extracellular polymers using scanning electron microscopy (SEM) monitored mRNA expression type I collagen (COL I) III III) as well small leucine-rich...
To explore the role of lysophosphatidic acid receptor 1 (LPAR1) and its correlation with PI3K/AKT pathway in development intratumoral heterogeneity (ITH) human ovarian serous cystadenocarcinoma (OSC).Immunohistochemical staining was performed to detect LPAR1 expression matched primary recurrent lesions from same patients. Cell models ITH were established using limiting dilution methodology Transwell invasion/migration assays. cell silenced or upregulated lentiviral particles, biological...
Interest surrounding the effect of irradiation on immune activation has exponentially grown within last decade.This includes work regarding mechanisms abscopal and success achieved by combination radiotherapy immunotherapy.It is hypothesized that triggers system to eliminate tumors inducing tumor cells immunogenic cell death (ICD) in cells.Activation ICD pathways can be exploited as an situ vaccine.In this review, we provide fundamental knowledge various forms caused irradiation, describe...
The standard treatment for cervical adenocarcinoma in situ (AIS) is hysterectomy, which a more aggressive than that used squamous intraepithelial lesions. Several previous studies have primarily demonstrated the loop electrosurgical excision procedure (LEEP) as safe and effective cold knife cone (CKC) biopsy when AIS unexpectedly found excision. This study evaluated safety of LEEP initial patients with who were strictly selected before after resection. oncological reproductive outcomes...