A5100378811- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- HIV/AIDS drug development and treatment
- Immune Cell Function and Interaction
- HIV-related health complications and treatments
- T-cell and B-cell Immunology
- Fungal Infections and Studies
- Syphilis Diagnosis and Treatment
- Hepatitis B Virus Studies
- SARS-CoV-2 and COVID-19 Research
- Cardiovascular Function and Risk Factors
- COVID-19 Clinical Research Studies
- Hematological disorders and diagnostics
- HIV, Drug Use, Sexual Risk
- Cardiovascular Disease and Adiposity
- Pneumocystis jirovecii pneumonia detection and treatment
- Bacillus and Francisella bacterial research
- Poxvirus research and outbreaks
- Tuberculosis Research and Epidemiology
- Liver Disease Diagnosis and Treatment
- Antifungal resistance and susceptibility
- Bone and Joint Diseases
- Reproductive tract infections research
- Herpesvirus Infections and Treatments
- CAR-T cell therapy research
Beijing Friendship Hospital
2024
Beijing Jishuitan Hospital
2021-2024
Capital Medical University
2014-2024
Peking University
2021-2024
Beijing YouAn Hospital
2014-2024
China Academy of Chinese Medical Sciences
2024
Jilin Province Tumor Hospital
2024
Southwest University
2024
Second Affiliated Hospital of Harbin Medical University
2022-2024
Harbin Medical University
2022-2024
Sexually transmitted infections (STIs) are common worldwide and pose a challenge to public health. We conducted this study assess the annual incidence of five STIs, including syphilis, chlamydia, gonorrhea, trichomoniasis, genital herpes at global, regional, national levels.We obtained detailed data on STIs excluding HIV from 1990 2019 Global Burden Disease (GBD) database. Estimated percentage change (EAPC) was calculated quantify trends in age-standardized rates (ASR) stratified by gender,...
This study compared the immunogenicity of inactivated SARS-CoV-2 vaccines between people living with HIV (PLWH) and HIV-negative individuals. We recruited 120 PLWH 53 individuals aged 18-59 years who had received an vaccine in two Chinese cities April June 2021. Blood samples were tested for vaccines. The prevalence severity adverse events associated similar seropositivity neutralizing activity against authentic SARS-CoV-2, total amount antibody (total antibody) S-IgG 71.3%, 81.9%, 92.6%,...
Purpose Ongoing Monkeypox (MPX) outbreaks in countries outside Africa have unique characteristics. However, data on cohorts of confirmed cases China is limited. The study provides important epidemiological, diagnostic, and clinical information about this disease China. Methods We report a series Chinese individuals with MPX infections identified at Beijing Youan Hospital (China) from June 10 to July 15, 2023. Samples were taken the skin, anus, throat, blood. An epidemiological questionnaire...
This study evaluated the prevalence and factors associated with sleep disturbance in a large cohort of HIV-infected patients across China. A cross-sectional was conducted among on antiretroviral therapy at 20 AIDS clinics. The Pittsburgh Sleep Quality Index self-administered by subjects. Socio-demographic characteristics, medical history HIV-related clinical data were collected. 4103 had complete for analysis. disturbances observed 43.1% patients. Associated multivariable analysis included...
Artemisinin, a traditional Chinese medicine with remarkable antimalarial activity. In recent years, studies demonstrated that artemisinin and its derivatives (ARTs) showed anti-inflammatory immunoregulatory effects. ARTs have been developed gradually applied to treat autoimmune inflammatory diseases. However, their role in the treament of patients diseases particular is less well recognized. This review will briefly describe history use diseases, theorized mechanisms action agents ARTs,...
Background Epidemics of HFMD are elevated every year globally, especially in mainland China. The disease now presents as an increasing threat to public health worldwide. Methods Five hundred and seventy-one EV71-infected patients Beijing You'an Hospital were grouped by severity: Mild (no severe complication) (n = 221), Severe group (complicated with brainstem encephalitis (BE), and/or pulmonary edema (PE) 350)). Clinical laboratory findings levels 7 serum cytokines analyzed. Results...
Monocytes have been recently subdivided into three subsets: classical (CD14++CD16-), intermediate (CD14++CD16+), and non-classical (CD14+CD16++) subsets, but phenotypic functional abnormalities of the monocyte subsets in HIV-1 infection not fully characterized, especially acute (AHI). In study, we explored dynamic changes their surface markers, association between IFN-γ, IL-4, IL-17 TNF-α producing CD4+ T cells chronic HIV-1-infected patients. We found that, individuals, frequency...
Background: Lopinavir/ritonavir (LPV/r) is a major antiretroviral treatment in China, but little known about the performance of first-line LPV/r-based regimens treatment-naïve patients with HIV-1. This study aims to assess efficacy and adverse effect events LPV/r plus lamivudine tenofovir or zidovudine as an initial HIV-1-infected individuals for whom cannot take efavirenz (EFV) allergic EFV. Methods: We performed retrospective registering China's National Free Antiretroviral Treatment...
HIV subtypes convey important epidemiological information and possibly influence the rate of disease progression. In this study, progression in patients infected with CRF01_AE, CRF07_BC, subtype B was compared largest molecular epidemiology study ever done China. A national data set pol sequences assembled by pooling from public databases Beijing laboratory network. Logistic regression used to assess factors associated risk AIDS at diagnosis ([AIDSAD], defined as a CD4 count < 200 cells/µL)...
Investigating immune memory to vaccinia virus and pre-existing immunity mpox (MPXV) among the population is crucial for global response this ongoing epidemic. Blood was sampled from vaccinees inoculated with Tiantan (VTT) strain born before 1981 unvaccinated control subjects since 1982. After at least 40 years of inoculation, 60% or 5% VTT possess neutralizing antibodies (NAbs) MPXV, 50% having T cell protein antigens. Notably, 46.7% show responses MPXV. Broad CD8+ reactivities MPXV are...
Abstract Background Albuvirtide is a once-weekly injectable human immunodeficiency virus (HIV)-1 fusion inhibitor. We present interim data for phase 3 trial assessing the safety and efficacy of albuvirtide plus lopinavir-ritonavir in HIV-1-infected adults already treated with antiretroviral drugs. Methods carried out 48-week, randomized, controlled, open-label non-inferiority at 12 sites China. Adults on World Health Organization (WHO)-recommended first-line treatment >6 months plasma...
In the COVID-19 outbreak year 2020, a consensus was reached on fact that SARS-CoV-2 spreads through aerosols. However, finding an efficient method to detect viruses in aerosols monitor risk of similar infections and enact effective control remains great challenge. Our study aimed build swirling aerosol collection (SAC) device collect viral particles exhaled breath subsequently using reverse transcription polymerase chain reaction (RT-PCR). Laboratory tests SAC aerosolized pseudovirus...
Understanding the facilitator of HIV-1 infection and subsequent latency establishment may aid discovery potential therapeutic targets. Here, we report elevation plasma transforming growth factor β (TGF-β) during acute among men who have sex with (MSM). Using a serum-free in vitro system, further delineated role TGF-β signaling mediating activated resting memory CD4+ T cells. could upregulate both frequency expression coreceptor CCR5, thereby augmenting CCR5-tropic viral cells via Smad3...
Abstract Background Most international treatment guidelines recommend rapid initiation of antiretroviral therapy (ART) for people newly diagnosed with human immunodeficiency virus (HIV)-1 infection, but experiences ART remain limited in China. We aimed to evaluate the efficacy and safety efavirenz (400 mg) plus lamivudine tenofovir disoproxil fumarate (EFV + 3TC TDF) versus coformulated bictegravir, emtricitabine, alafenamide (BIC/FTC/TAF) among men who have sex (MSM) been HIV. Methods This...
<abstract abstract-type="Summary"> <sec> <b>What is already known about this topic?</b> The prevalence of monkeypox (mpox) infections primarily observed among young men who engage in sexual activities with other men, and there a possibility transmission. Co-occurring sexually transmitted have also been documented. </sec><sec> added by report?</b> In report, we present case patient China was simultaneously diagnosed mpox, acute human immunodeficiency virus (HIV) infection. exhibited symptoms...
Abstract We conducted a prospective cohort study among HIV-negative MSM aged 18 years or older between 2007 and 2012 in Beijing, China to measure the rates of incident HIV identify risk factors for infection. Among 5,800 participants evaluated at enrollment, we identified 486 prevalent cases (8.4%). 3,625 enrollees who were enrollment completed least one follow-up interview, 440 follow up period: this constituted an incidence rate 7.1 per 100 person-years (95% CI: 6.4–7.7). Early treatment...