A5100737310- Optical Coherence Tomography Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Immune cells in cancer
- RNA modifications and cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Aldose Reductase and Taurine
- Acute Ischemic Stroke Management
- Retinal Diseases and Treatments
- Glioma Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Barrier Structure and Function Studies
- Autophagy in Disease and Therapy
- Heme Oxygenase-1 and Carbon Monoxide
- RNA Research and Splicing
- Glaucoma and retinal disorders
- Circular RNAs in diseases
- Epigenetics and DNA Methylation
- Clostridium difficile and Clostridium perfringens research
- Dermatological and COVID-19 studies
- Calpain Protease Function and Regulation
- Prenatal Substance Exposure Effects
- Inflammasome and immune disorders
- Neurogenesis and neuroplasticity mechanisms
- Advanced Fluorescence Microscopy Techniques
Tianjin Huanhu Hospital
2012-2025
Northwestern University
2024
Columbia University
2022-2024
Tianjin Medical University
2014-2015
Novem (Netherlands)
2014
Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-reperfusion (IR) injury, but the mechanism is not yet clear. Tissue-type plasminogen activator (tPA) most thrombolytic drug clinical treatment ischemic stroke and has neuroprotective effects. Here, we explored effects tPA on neuronal apoptosis mitophagy following IR. We found that knocking out gene significantly aggravated brain injury increased mitochondrial damage. Exposure neurons to reduced severity...
UHRF1, an epigenetic factor, is implicated in various cellular processes of tumorigenesis. However, the modulation UHRF1 expression human bladder cancer at post-transcriptional levels remains unclear. Here, we report that miR-124 suppresses to affect progression through competitive binding same region its 3'-UTR. We show compared with corresponding normal tissues, upregulated and downregulated demonstrating inverse correlation UHRF1. Quantitative PCR western blot assay demonstrated...
We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). used a fanout periodically poled lithium niobate (PPLN) crystal for second-harmonic generation (SHG) to convert commercial near-infrared (NIR-SS) laser into SS laser. To enhance SHG efficiency, we amplified NIR-SS output with booster amplifiers (BOAs) and generated up 580 µW power. The SS-vis-OCT achieved maximum axial resolution 7.3 µm an imaging depth 5 mm in air, corresponding 5.4 3.7...
Acute lung injury (ALI) is a serious yet common complication in patients with traumatic brain (TBI), often associated poor prognosis. The development of TBI-induced ALI closely excessive oxidative stress and NLRP3 inflammasome activation. Fingolimod, an immunomodulatory agent, has been reported to attenuate inflammatory responses, restore blood-brain barrier integrity, reduce cerebral edema, mitigate neurological deficits. This study aimed investigate the mechanistic role activation evaluate...
Abstract Accumulating evidence indicates that the dysregulation of miRNAs/mRNA-mediated carcinogenic signaling pathway network is intimately involved in glioma initiation and progression. In present study, by performing experiments bioinformatics analysis, we found RPN2 was markedly elevated specimens compared with normal controls, its upregulation significantly linked to WHO grade poor prognosis. Knockdown inhibited tumor proliferation invasion, promoted apoptosis, enhanced temozolomide...
<b><i>Purpose:</i></b> Lactate dehydrogenase A (LDHA), which functions as a crucial enzyme in transforming from pyruvate into lactate, has been reported to be overexpressed various advanced cancer and its silencing turned out tumor suppressive. Previous studies have showed that the expression of LDHA was higher renal cell carcinoma (RCC) than corresponding normal tissue. However, function RCC, possible mechanism progression, not investigated....
α-l-Fucosidase 1 (FUCA1), a lysosomal enzyme that catalyses the hydrolytic cleavage of terminal fucose residue, has been reported to be involved in tumorigenesis. However, clinical significance and biological roles FUCA1 glioma remain largely unknown. We analyzed expression according data Oncomine, The Cancer Genome Atlas, Chinese Glioma Atlas databases further verified with immunohistochemistry real-time PCR analysis tissues. results showed overexpression was significantly associated...
AGINGHowever, in addition to the thrombolytic function of rt-PA, a growing body evidence indicates that rt-PA treatment increases permeability blood-brain barrier (BBB) [3,4].Ischemic stroke BBB, resulting development cerebral edema.Moreover, increased incidence intracranial hemorrhage acute ischemic patients www.aging-us.com
Excessive inflammation leads to secondary immune damage after traumatic brain injury (TBI). The intestinal mucosa is a key component of tolerance due gut-brain axis regulation, but the curative effect not optimal. Intestinal dysfunction impairs establishment in patients with TBI. Therefore, we orally administered protein (BP) combined probiotics induce and explored mechanism by which homeostasis microbiota contributes enhancement effects BPs. Herein, demonstrated that TBI surgical (SBI)...
Background Many researches demonstrate that the secondary brain injury which is caused by autoimmune attack toward antigens plays an important role in surgical (SBI). Although traditional immunosuppression can reduce attack, it will lower body immunity. Immune tolerance, contrast, not only does immunity, but also could lighten autoimmunity. This study used thymus tolerance to develop immune system tolerant autologous cerebrospinal fluid (CSF) and tissue so be suppressed following disruption...
Background: The interaction between activated microglia and T lymphocytes can yield abundant pro-inflammatory cytokines. Our previous study proved that thymus immune tolerance could alleviate the inflammatory response. This aimed to investigate whether intrathymic injection of myelin basic protein (MBP) in mice suppress response after co-culture BV-2 cells. Methods: Totally, 72 male C57BL/6 were randomly assigned three groups (n = 24 each): Group A: 100 μl MBP (1 mg/ml); B:...
MicroRNAs (miRs), which act as crucial regulators of oncogenes and tumor suppressors, have been confirmed to play a significant role in the initiation progression various malignancies, including glioma. The present study analyzed expression roles miR‑422a glioma, reverse transcription‑quantitative PCR that was significantly lower glioblastoma multiforme (GBM) samples cell lines compared with low‑grade glioma H4 line, respectively. overexpression suppressed proliferation invasion, induced...
Hyperreflective foci (HRFs) appear in optical coherence tomography (OCT) images of the retina and vitreous patients with various ocular diseases. HRFs are hypothesized to be immune cells that response ischemia or tissue damage. To accurately identify establish their clinical significance, it is necessary replicate detection similar patterns vivo a small animal model. We combined visible-light OCT temporal speckle averaging (TSA) visualize track vitreal (VHRFs) densities for three days after...
Visible‐light optical coherence tomography (vis‐OCT) is a novel noninvasive retinal imaging system that offers improved resolution compared to conventional near‐infrared (NIR) OCT systems. Here, we utilized vis‐OCT produce fibergrams (vis‐OCTF) for the first time in human patients, enabling en face visualization and precise quantification of hyperreflective dots central fovea two patients. We also directly compare qualities NIR‐OCT. Vis‐OCT generated 3 × mm 2 image with an impressive axial...
We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). used a fanout periodically poled lithium niobate (PPLN) crystal for second harmonic generation (SHG) to convert commercial near-infrared (NIR-SS) laser into SS laser. To enhance SHG efficiency, we amplified NIR-SS output with booster amplifiers (BOAs). experimentally characterized SS-vis-OCT performance using two different BOAs, one yielding 48 nm bandwidth and 60 μW power, while other...
We demonstrate the feasibility of swept-source visible-light optical coherence tomography (SS-vis-OCT). used a fanout periodically poled lithium niobate (PPLN) crystal for second harmonic generation (SHG) to convert commercial near-infrared (NIR-SS) laser into SS laser. To enhance SHG efficiency, we amplified NIR-SS output with booster amplifiers (BOAs). experimentally characterized SS-vis-OCT performance using two different BOAs, one yielding 48 nm bandwidth and 60 μW power, while other...