A5100387435- Cancer, Hypoxia, and Metabolism
- Pancreatic and Hepatic Oncology Research
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Acute Ischemic Stroke Management
- Pituitary Gland Disorders and Treatments
- Cell Adhesion Molecules Research
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Adrenal and Paraganglionic Tumors
- Cancer Research and Treatments
- Tissue Engineering and Regenerative Medicine
- interferon and immune responses
- Chronic Kidney Disease and Diabetes
- Peptidase Inhibition and Analysis
- Protease and Inhibitor Mechanisms
- Vascular Tumors and Angiosarcomas
- Foot and Ankle Surgery
- Adipokines, Inflammation, and Metabolic Diseases
- Ubiquitin and proteasome pathways
- Atherosclerosis and Cardiovascular Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Hormonal Regulation and Hypertension
- Luminescence Properties of Advanced Materials
- Cerebrovascular and Carotid Artery Diseases
Air Force Medical University
2022-2025
Xijing Hospital
2022-2025
Third Hospital of Hebei Medical University
2015-2024
Hebei Medical University
2015-2024
China-Japan Friendship Hospital
2023
Tianjin University
2022
Tianjin Huanhu Hospital
2015-2022
Renji Hospital
2009-2022
Shanghai Jiao Tong University
2021-2022
Tianjin Medical University
2022
Autophagy of mitochondria, termed mitophagy, plays an important role in cerebral ischemia-reperfusion (IR) injury, but the mechanism is not yet clear. Tissue-type plasminogen activator (tPA) most thrombolytic drug clinical treatment ischemic stroke and has neuroprotective effects. Here, we explored effects tPA on neuronal apoptosis mitophagy following IR. We found that knocking out gene significantly aggravated brain injury increased mitochondrial damage. Exposure neurons to reduced severity...
Abstract Doxorubicin, a representative drug of the anthracycline class, is widely used in cancer treatment. However, Doxorubicin-induced cardiotoxicity (DIC) presents significant challenge its clinical application. Mitochondrial dysfunction plays central role DIC, primarily through disrupting mitochondrial dynamics. This study aimed to investigate impact Rnd3 (a Rho family GTPase 3) on with focus Cardiomyocyte-specific transgenic mice (Rnd3-Tg) and LSP/LSP (N-Tg) were established for vivo...
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with an extremely poor prognosis. Effective targets for anticancer therapy confirmed in PDAC are limited. However, the characteristics of genomics have not been fully elucidated large-scale patients from China.We collected both blood and tissue samples 1080 Chinese pancreatic cancer retrospectively investigated genomic landscape using next-generation sequencing (NGS).We found recurrent somatic mutations KRAS (83.2%), TP53 (70.6%),...
Rationale: Extracellular matrix (ECM) remodeling, a key pathological feature in diabetic cardiomyopathy (DCM), is triggered by oxidative stress, inflammation, and various metabolic disorders the heart.Cardiac fibroblasts (CFs) are primary source of ECM proteins ultimate effector cells remodeling.CFs turned on differentiated into myofibroblasts response to profibrotic signaling.Rnd3 small Rho-GTPase involved regulation cell-cycle distribution, cell migration, morphogenesis.Emerging evidence...
Microvascular complications are associated with an overtly increased risk of adverse outcomes in patients diabetes including coronary microvascular injury which manifested as disruption adherens junctions between cardiac endothelial cells (CMECs). However, particular mechanism leading to diabetic hyperpermeability remains elusive.Experimental was induced mice adipose tissue-specific Adipsin overexpression (AdipsinLSL/LSL-Cre) and their respective control (AdipsinLSL/LSL). In addition,...
Abstract Background As the main pathological basis for various cardiovascular and cerebrovascular diseases, atherosclerosis has become one of leading causes death disability worldwide. Emerging evidence suggested that Rho GTPase Rnd3 plays an indisputable role in although its function remains unclear. Here, we found a significant correlation between pyroptosis aortic endothelial cells (ECs). Methods Apoe KO mice were utilized as model atherosclerosis. Endothelium‐specific transgenic employed...
As a vital adipokine, Adipsin is closely associated with cardiovascular risks. Nevertheless, its role in the onset and development of diseases remains elusive. This study was designed to examine effect on survival, cardiac dysfunction adverse remodeling face myocardial infarction (MI) injury. In vitro experiments were conducted evaluate effects cardiomyocyte function hypoxic challenge mechanisms involved. Our results showed that dramatically altered expression proteins iron metabolism...
Phagocytosis of oxidized low-density lipoprotein (OxLDL) by macrophages yields “foam cells” and serves as a hallmark atherosclerotic lesion. Adipsin is critical component the complement activation pathway. Recent evidence has indicated an obligatory role for in pathological models including ischemia-reperfusion sepsis. levels are significantly decreased patients with asymptomatic carotid atherosclerosis, implying potential marker atherosclerosis. This study was designed to evaluate...
Diabetic microvascular dysfunction is evidenced by disrupted endothelial cell junctions and increased permeability. However, effective strategies against these injuries remain scarce. In this study, the type 2 diabetes mouse model was established high-fat diet combined with streptozotocin injection in Rnd3 endothelial- specific transgenic knockout mice. Echocardiography employed to evaluate cardiac function. Microvascular corrosion casts, lanthanum nitrate perfusion, trans- electrical...
<p dir="ltr">Diabetic microvascular dysfunction is evidenced by disrupted endothelial cell junctions and increased permeability. However, effective strategies against these injuries remain scarce. In this study, the type 2 diabetes mouse model was established high-fat diet combined with streptozotocin injection in Rnd3 endothelial-specific transgenic knockout mice. Echocardiography employed to evaluate cardiac function. Microvascular corrosion casts, lanthanum nitrate perfusion,...
<p dir="ltr">Diabetic microvascular dysfunction is evidenced by disrupted endothelial cell junctions and increased permeability. However, effective strategies against these injuries remain scarce. In this study, the type 2 diabetes mouse model was established high-fat diet combined with streptozotocin injection in Rnd3 endothelial-specific transgenic knockout mice. Echocardiography employed to evaluate cardiac function. Microvascular corrosion casts, lanthanum nitrate perfusion,...
This study was designed to assess the prevalence of chronic kidney disease (CKD) and associated risk factors among Chinese population in Taian, China.A primary care-based cross-sectional conducted China, from September December 2012. Participants selected by a multi-stage stratified cluster sampling procedure were interviewed tested for hematuria, albuminuria, estimated glomerular filtration rate (eGFR) other clinical indices. Factors with CKD analyzed univariate multivariate logistic...
Cortactin acts as a prominent substrate of histone deacetylases (HDACs) and plays important roles in tumour progression several human cancers. However, the clinical significance its expression prostate cancer (PCa) has not been determined. We aimed to identify potential role cortactin prognosis PCa association with HDACs.256 foci distinctive lesions 110 specimens were collected status among cortactin, SIRT2, deacetylase 6 (HDAC6) by immunohistochemistry relationship clinicopathological...
Basement membrane degradation and blood-brain barrier damage appear after cerebral infarction, severely impacting neuronal brain functioning; however, the underlying pathogenetic mechanisms remain poorly understood. In this study, we induced infarction in stroke-prone spontaneously hypertensive rats by intragastric administration of high-sodium water (1.3% NaCl) for 7 consecutive weeks. Immunohistochemical immunofluorescence assays demonstrated that, compared with non-infarcted contralateral...
The hippocampal CA1 region is sensitive to hypoxic and ischemic injury but can be protected by preconditioning (IPC). However, the mechanism through which IPC protects neurons still under investigation. Additionally, role of autophagy in determining fate unclear. Here, we examined whether induced alleviate neuronal death vitro vivo with oxygen glucose deprivation (OGD) bilateral carotid artery occlusion (BCCAO) models. Survival increased from 51.5% ± 6.3% non-IPC group (55 min OGD) 77.3%...
Forkhead box K2 (FOXK2) is a member of the forkhead family transcription factors. Recently, researchers discovered that overexpression FOXK2 inhibits proliferation and metastasis breast cancer, non-small cell lung colorectal related to clinical prognosis. However, in hepatocellular carcinoma, results opposite phenotypes. Currently, contribution glioma pathogenesis not clear.We evaluated expression 151 patients using immunohistochemistry assays. The associations among FOXK2,...
Abstract Background Diabetic cardiomyopathy (DCM) causes the myocardium to rely on fatty acid β-oxidation for energy. The accumulation of intracellular lipids and acids in usually results lipotoxicity, which impairs myocardial function. Adipsin may play an important protective role pathogenesis DCM. aim this study is investigate regulatory effect DCM lipotoxicity its molecular mechanism. Methods A high-fat diet (HFD)-induced type 2 diabetes mellitus model was constructed mice with adipose...
The effect of hepatitis B immunoglobulin (HBIG) on virus (HBV) DNA load and its protective mechanism are not well understood. Twenty-eight surface antigen (HBsAg)–positive pregnant women their newborns were assigned to an experimental (n = 12) or control group 16) according whether they received HBIG during pregnancy. HBV markers titer the mothers tested. These in did fluctuate significantly comparable control. In group, there was a positive correlation between with regard antibody titer....
We aimed to compare the safety and patient outcomes of retroperitoneal paraganglioma (PG) following retroperitoneoscopic transperitoneoscopic approaches based on large samples. Seventy-four patients with PG undergoing laparoscopic resection from June 2004 September 2013 were retrospectively included. The divided into (n = 40) transperitoneal 34) groups. Demographic perioperative data, including operation time, estimated blood loss, incidence intraoperative hypertension, bowel recovery day,...
We report on the diameter dependence luminescence property of CsI(Na) crystals under X-ray excitation. When crystal decreases to nano-scale, excited decay time is speeding up from ∼600 ns ∼10 and 420 nm Na-related cathodeluminescence affected drastically. The reason confirmed that reduction leads surface effect accelerate excitons' quenching. These measurement results identify a critical distinguished boundary ∼20 μm) diameter, which provide new way potential application in development fast...