A5100406720- Pancreatic and Hepatic Oncology Research
- Immune cells in cancer
- Epigenetics and DNA Methylation
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Cancer Immunotherapy and Biomarkers
- Phagocytosis and Immune Regulation
- Histone Deacetylase Inhibitors Research
- Cancer Genomics and Diagnostics
- Protein Degradation and Inhibitors
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Hippo pathway signaling and YAP/TAZ
- Plant Pathogens and Fungal Diseases
- Cancer Research and Treatments
- Caveolin-1 and cellular processes
- Ferroptosis and cancer prognosis
- Genetics and Plant Breeding
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related gene regulation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Immune Cell Function and Interaction
- interferon and immune responses
Renji Hospital
2016-2025
Shanghai Jiao Tong University
2014-2025
Shanghai Cancer Institute
2017-2025
State Key Laboratory of Oncogene and Related Genes
2017-2024
Second Xiangya Hospital of Central South University
2023
Central South University
2023
First Hospital of Qinhuangdao
2023
Hebei Medical University
2023
Dalian University of Technology
2023
New York University
2023
Abstract The mechanisms responsible for radioresistance in pancreatic cancer have yet to be elucidated, and the suppressive tumor immune microenvironment must considered. We investigated whether radiotherapy-augmented Warburg effect helped myeloid cells acquire an immunosuppressive phenotype, resulting limited treatment efficacy of ductal adenocarcinoma (PDAC). Radiotherapy enhanced tumor-promoting activity myeloid-derived suppressor (MDSC) cancer. Sustained increase lactate secretion, from...
Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among top upregulated metabolic genes in several immunotherapy-resistant tumors. We show that CDA cells contributes uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y
Many types of human tumour cells overexpress the dual-specificity phosphatase Cdc25A. Cdc25A dephosphorylates cyclin-dependent kinase and regulates cell cycle, but other substrates their relevant cellular functions have yet to be identified. We demonstrate here that EGFR activation results in c-Src-mediated phosphorylation at Y59, which interacts with nuclear pyruvate M2 (PKM2). PKM2 S37, promotes PKM2-dependent β-catenin transactivation c-Myc-upregulated expression glycolytic genes GLUT1,...
Pancreatic ductal adenocarcinoma (PDAC) is a deadly disease, and its incidence increasing annually. It critical to reveal delineate the molecular mechanism promoting PDAC development progression. Mammalian STE20-like kinase 1 (MST1) proapoptotic cytoplasmic also one of core components Hippo pathway. Here, we showed that MST1 expression was decreased in PDAC, restored promoted cell death suppressed proliferation, migration, invasion, spheroid formation via caspase-1-induced pyroptosis....
Abstract In many types of cancer, tumor cells prefer to use glycolysis as a major energy acquisition method. Here, we found that the 18 fluoro-deoxyglucose (FDG) positron emission tomography (PET)/computed (CT)-based markers were positively associated with expression programmed cell death ligand 1 (PD-L1), pyruvate kinase M2 (PKM2), both which indicate poor prognosis in patients pancreatic ductal adenocarcinoma (PDAC). However, regulatory mechanism PD-L1 remains elusive. this study,...
Pterostilbene (Pt) is a natural polyphenol found in blueberries and several grape varieties. Pt's pharmacological importance was well documented. Nevertheless, the depigmenting effects are not demonstrated. We evaluated through autophagy induction B16F10 cells inhibition of UVA (3 J/cm2)-irradiated α-MSH keratinocyte HaCaT via Nrf2-mediated antioxidant pathways. Pt (2.5-5μM) attenuated ROS production downregulated POMC/α-MSH pathway cells. The conditioned medium-derived from UVA-irradiated...
Pancreatic ductal adenocarcinoma (PDAC) is a malignant tumor with an extremely poor prognosis. Effective targets for anticancer therapy confirmed in PDAC are limited. However, the characteristics of genomics have not been fully elucidated large-scale patients from China.We collected both blood and tissue samples 1080 Chinese pancreatic cancer retrospectively investigated genomic landscape using next-generation sequencing (NGS).We found recurrent somatic mutations KRAS (83.2%), TP53 (70.6%),...
Our previous research defined a novel metabolic cancer associated fibroblasts subset (meCAFs) enriched in loose-type pancreatic ductal adenocarcinoma (PDAC) and related to CD8+ T cells accumulation. Consistently, the abundance of meCAFs was with poor prognosis but better immunotherapy responses PDAC patients. However, characteristic its cross-talk remain be elucidated. In this study, we identified PLA2G2A as marker meCAFs. particular, PLA2G2A+ positively accumulation total negatively...
The mutualism pattern of the dark septate endophyte (DSE) Harpophora oryzae in rice roots and its biocontrol potential blast disease caused by Magnaporthe were investigated. Fluorescent protein-expressing H. was used to monitor colonization pattern. Hyphae invaded from epidermis inner cortex, but not into root stele. Fungal increased with tissue maturation, showing no meristematic zone, slight elongation heavy differentiation zone. adopted a biotrophic lifestyle accompanied programmed cell...
Chondroitin polymerizing factor (CHPF) is an important glycosyltransferase involved in the biosynthesis of chondroitin sulfate. However, relationship between CHPF and gastric cancer has not been fully investigated. expression tissues was detected by immunohistochemistry correlated with patient prognosis. Cultured cells human epithelial cell line GES1 were used to investigate effects shCHPF shE2F1 on development progression MTT, western blotting, flow cytometry analysis apoptosis, colony...
Asymmetrical localization of transcripts coupled with localized translation constitutes an important mechanism widely deployed to regulate gene activity in a spatial manner. The conserved transmembrane protein Crumbs (Crb) is regulator epithelial polarity. However, it remains unclear how Crb targeted the apical domain. Here, we show that cytoplasmic dynein complex transports both and domain Drosophila melanogaster follicular cells (FCs). crb 3′ untranslated region (UTR) necessary sufficient...
Abstract Liposomal irinotecan has shown promising antitumor activity in patients with advanced or metastatic pancreatic ductal adenocarcinoma (PDAC) who have undergone prior gemcitabine-based therapies. This randomized, double-blind, parallel-controlled, multicenter phase 3 study (NCT05074589) assessed the efficacy and safety of liposomal HR070803 combined 5-fluorouracil (5-FU) leucovorin (LV) this patient population. Patients unresectable, locally advanced, PDAC had previously received...
To date, a growing body of evidence suggests that unfolded protein response (UPR) sensors play vital role in carcinogenesis. However, it remains unclear whether they are involved pancreatic ductal adenocarcinoma (PDAC) and how relate to clinical outcomes. This study aims investigate the biological function mechanism novel UPR sensor, CREB3L1 works PDAC further evaluate its application prospect. We tested signaling including Thapsigargin-treated cells. Subsequently, we defined expression...
Maize plant height related traits including height, ear and internode number are tightly linked with biomass, planting density, grain yield in the field. Previous studies have focused on understanding genetic basis of architecture per se, but combining ability remains poorly understood. In this study, 328 recombinant inbred lines were inter-group crossed two testers to produce 656 hybrids using North Carolina II mating design. Both parental evaluated summer maize-growing regions China 2015...
<h3>Objective:</h3> Pancreatic ductal adenocarcinoma (PDAC) is a disease with high mortality. Many so-called "junk" noncoding RNAs need to be discovered in PDAC. The purpose of this study was therefore investigate the function and regulatory mechanism long RNA MEG3 <h3>Methods:</h3> Gene Expression Omnibus database (GEO database) used determine differential expression PDAC, selected for subsequent verification. Tissue cell samples were verify expression, followed by functional detection...
Next-generation sequencing (NGS) technology is capable of millions or billions DNA molecules simultaneously. Therefore, it represents a promising tool for the analysis molecular targets initial diagnosis disease, monitoring disease progression, and identifying mechanism drug resistance. On behalf Tumor Biomarker Committee Chinese Society Clinical Oncology (CSCO) China Actionable Genome Consortium (CAGC), present expert group hereby proposes advisory guidelines on clinical applications NGS...
Mps1 binding protein (MOB1) is one of the core components mammalian Hippo pathway and plays important roles in cancer development. However, its expression, function regulation pancreatic ductal adenocarcinoma (PDAC) have not been revealed yet. The expression MOB1 lysine demethylase 2B (KDM2B) PDAC adjacent normal pancreas tissues were measured. Also, underlying mechanisms altered impact on biology investigated. We for first time that was decreased a statistically significant independent...
Pancreatic cancer (PC) is a fatal tumor with high mortality. Pyroptosis plays suppressor role as novel cell death. However, the influences of pyroptosis-related lncRNAs (PRlncRNAs) on prognosis and microenvironment (TME) infiltration have not been fully studied in PC. Using coexpression analysis univariate Cox regression analysis, we identified seventeen prognostic PRlncRNAs from The Cancer Genome Atlas (TCGA) dataset, which were all expressed differently normal samples. A seven-PRlncRNA...
Myeloid-derived suppressor cells (MDSCs) are a population of immature bone marrow that accumulate in large numbers the spleen, peripheral blood, marrow, lymph nodes, and local metastatic foci tumors. C/EBP homologous protein (CHOP) CCAAT/enhancer binding β (C/EBPβ) play key roles regulating immunosuppressive function differentiation MDSCs. Our study revealed long noncoding RNA Lnc-17Rik was able to promote immunosuppression tumors by facilitating activation expression genes involved MDSC...