A5040251176- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Nanoparticle-Based Drug Delivery
- 3D Printing in Biomedical Research
- Quantum Dots Synthesis And Properties
- Graphene and Nanomaterials Applications
- Cancer Cells and Metastasis
- Immune cells in cancer
- Immune Cell Function and Interaction
- Cancer, Stress, Anesthesia, and Immune Response
- Laser-Ablation Synthesis of Nanoparticles
- Immunotoxicology and immune responses
- Animal testing and alternatives
- Adenosine and Purinergic Signaling
- RNA Interference and Gene Delivery
KU Leuven
2020-2025
Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among top upregulated metabolic genes in several immunotherapy-resistant tumors. We show that CDA cells contributes uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y
Despite efforts in producing nanoparticles with tightly controlled designs and specific physicochemical properties, these can undergo massive nano-bio interactions bioprocessing upon internalization into cells. These transformations generate adverse biological outcomes premature loss of functional efficacy. Hence, understanding the intracellular fate is a necessary prerequisite for their introduction medicine. Among nanomaterials devoted to theranostics copper sulfide (CuS), which provides...
Abstract Cancer immunotherapy has emerged as a promising approach for the induction of an antitumor response. While response rates are very high in some cancers, efficacy against solid tumors remains limited caused by presence immunosuppressive tumor microenvironment. Induction immunogenic cell death (ICD) can be used to boost cancers eliciting release immune‐stimulatory components. However, delivery components inducing ICD sites challenge. Here, novel method is described therapy based on...
Nanoparticle (NP) delivery to solid tumors remains an actively studied field, where several recent studies have shed new insights into the underlying mechanisms and still overall poor efficacy. In present study, Au NPs of different sizes were used as model systems address this topic, systemically administered tumor a whole or cells specifically was examined in view broad range tumor-associated parameters. Using non-invasive imaging combined with histology, immunohistochemistry, single-cell...
Abstract Cancer immunotherapy is often hindered by an immunosuppressive tumor microenvironment (TME). Various strategies are being evaluated to shift the TME from immunologically ‘cold’ ‘hot’ and hereby improve current immune checkpoint blockades (ICB). One particular hot topic use of combination therapies. Here, we set out screen a variety metallic nanoparticles explored their in-vitro toxicity against series non-tumor cell lines. For silver nanoparticles, also effects core size surface...
Abstract Exploring alternatives to in vivo models, this study validates Precision Cut Lung Slices (PCLS) as a viable ex platform for lung cancer research. We established the prolonged viability and structural preservation of PCLS, essential accurate drug response studies. Using Paclitaxel benchmark therapeutically promising silver nanoparticles combination with immunotherapy, we conducted pioneering comparative analysis its therapeutic effects on PCLS against traditional models. Results...
Cancer immunotherapy is often hindered by an immunosuppressive tumor microenvironment (TME). Various strategies are being evaluated to shift the TME from immunologically 'cold' 'hot' and hereby improve current immune checkpoint blockades (ICB). One particular hot topic use of combination therapies. Here, we set out screen a variety metallic nanoparticles explored their in vitro toxicity against series non-tumor cell lines. For silver nanoparticles, also effects core size surface chemistry on...