A5008042144- Extracellular vesicles in disease
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Surgical Treatments
- Inflammatory Biomarkers in Disease Prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Peptidase Inhibition and Analysis
- Colorectal Cancer Screening and Detection
- MicroRNA in disease regulation
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Phagocytosis and Immune Regulation
- Gastric Cancer Management and Outcomes
- Genetic factors in colorectal cancer
- Proteoglycans and glycosaminoglycans research
- Gallbladder and Bile Duct Disorders
- Gastrointestinal Tumor Research and Treatment
- Cancer Immunotherapy and Biomarkers
- Colorectal Cancer Treatments and Studies
- Adenosine and Purinergic Signaling
- Nanoplatforms for cancer theranostics
- Pancreatitis Pathology and Treatment
- Anorectal Disease Treatments and Outcomes
- Immune Cell Function and Interaction
- Epigenetics and DNA Methylation
- Economic and Financial Impacts of Cancer
TU Dresden
2014-2025
University Hospital Carl Gustav Carus
2015-2025
National Center for Tumor Diseases
2022-2025
Heidelberg University
2023-2025
German Cancer Research Center
2023-2025
Helmholtz-Zentrum Dresden-Rossendorf
2023-2025
VIB-KU Leuven Center for Cancer Biology
2024
University Hospital Heidelberg
2023
Klinik und Poliklinik für Hals-, Nasen-, Ohrenheilkunde
2017
Klinik und Poliklinik für Psychotherapie und Psychosomatik
2017
Many individuals with cancer are resistant to immunotherapies. Here, we identify the gene encoding pyrimidine salvage pathway enzyme cytidine deaminase (CDA) among top upregulated metabolic genes in several immunotherapy-resistant tumors. We show that CDA cells contributes uridine diphosphate (UDP) pool. Extracellular UDP hijacks immunosuppressive tumor-associated macrophages (TAMs) through its receptor P2Y
The prognosis of pancreatic ductal adenocarcinoma (PDAC) is one the most dismal all cancers and median survival PDAC patients only 6-8 months after diagnosis. While decades research effort have been focused on early diagnosis understanding molecular mechanisms, few clinically useful markers universally applied. To improve treatment management PDAC, it equally relevant to identify prognostic factors for optimal therapeutic decision-making patient survival. Compelling evidence suggested...
The treatment of colorectal cancer (CRC) has improved during the last decades, but methods for crucial early diagnosis are yet to be developed. influence tumour microenvironment on liquid biopsies diagnostics gaining growing interest, especially with emphasis exosomes (EXO), a subgroup extracellular vesicles (EVs). In this study, we established paired cancer-associated (CAFs) and normal fibroblasts (NF) from 13 CRC patients investigated activation status-related protein abundance in derived...
Pancreatic cancer consists of a heterogenous bulk tumor cells and stroma which contribute to progression by releasing angiogenic factors. Those factors can be detected as circulating serum We performed compartment-specific analysis tumor-derived stroma-derived identify biomarkers molecular targets for the treatment pancreatic cancer. Kryo-frozen tissue from primary ductal adenocarcinomas (n = 51) was laser-microdissected isolate tissue. Expression 17 (angiopoietin-2, follistatin, GCSF, HGF,...
Clinical abundance of artificial intelligence has increased significantly in the last decade. This survey aims to provide an overview current state knowledge and acceptance AI applications among surgeons Germany.
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) exhibits a high frequency of neural invasion (NI). Schwann cells (SCs) have been shown to be reprogrammed facilitate cancer cell migration and into nerves. Since extracellular vesicles (EVs) affect the tumour microenvironment promote metastasis, present study analysed involvement EVs from pancreatic their in altering SC phenotype as part early events process NI. Methods were isolated human/murine PDAC cells, stellate (PSCs), human...
Epithelial-to-mesenchymal transition (EMT) contributes significantly to tumor progression and metastasis. The assessment of EMT-associated transcription factors could be a promising approach identify biomarkers potential therapeutic targets in colorectal cancer. In our study, we focused on the factor "Sine oculis homeobox" (SIX) 1, which is member superfamily homeobox genes has been described promote EMT different types tumors. Immunohistochemistry against SIX1 was performed mucosa,...
Tumour-associated stroma has a critical role in tumour proliferation. Our aim was to determine specific protein expression profile of stromal angiogenic cytokines and matrix metalloproteinases (MMPs) identify potential biomarkers or new therapy targets. Frozen tissue primary colorectal cancer (n=25), liver (n=25) lung metastases (n=23) laser-microdissected obtain epithelial cells adjacent tumour-associated stroma. Protein nine eight MMPs analysed using multiplex-based assay. We found...
Epithelial-to-mesenchymal transition (EMT) and cancer stem cells (CSC) contribute to tumour progression metastasis. Assessment of transcription factors involved in these two mechanisms can help identify new targets for an oncological therapy. In this study, we focused on the evaluation factor Six1 (Sine oculis 1). This protein is embryologic development its contribution carcinogenesis has been described several studies.Immunohistochemistry against was performed a tissue microarray containing...
MicroRNAs are small non-coding RNAs with a length of 18–25 nucleotides. They can regulate tumor invasion and metastasis by changing the expression translation their target mRNAs. Their is substantially altered in colorectal cancer cells as well adjacent tumor-associated stroma. Both these compartments have mutual influence on progression. In development metastases, initially interact host tissue. Therefore, compartment-specific signatures three locations—tumor, associated stroma, tissue—can...
Exosomes are nano-sized membranous vesicles of endosomal origin that carry nucleic acids, lipids and proteins. The cargo exosomes is cell specific the release these uptake by an acceptor seen as a vital element cell-cell communication. Here, we sought to investigate diagnostic prognostic value expression glypican 3 (GPC3) on primary gastro-esophageal adenocarcinoma (GEA) tissue (tGPC3) corresponding serum (eGPC3). Circulating were extracted from samples 49 patients with GEA 56 controls....
Anastomotic leakage (AL) and surgical site infection (SSI) account for most postoperative complications in colorectal surgery. The aim of this retrospective trial was to investigate whether perioperative selective decontamination the digestive tract (SDD) reduces these provide a cost-effectiveness model elective surgery.All patients operated between November 2016 March 2020 were included our analysis. Patients primary cohort (PC) received SDD those historical control (CC) did not receive...
The treatment of choice for patients presenting with obstructive cholestasis due to periampullary carcinoma is oncologic resection without preoperative biliary drainage (PBD). However, PBD becomes virtually impossible in cholangitis or severely impaired liver cell function. appropriate duration by has not yet been defined these patients.A retrospective analysis was conducted on 170 scheduled pancreatic following between January 2012 and June 2018 at the University Hospital Dresden Germany....
BACKGROUND: Pancreatic cancer is the 4th leading cause of cancer-related death with poor survival even after curative resection. RAB27A and RAB27B are key players in exosome pathway where they play important roles secretion. Evidence suggests that expression not only leads to tumor proliferation invasion, but also plays an role antigen transfer necessary for anticancer immunity. OBJECTIVE: In this study, we analyze patients pancreatic surgery or without adjuvant chemotherapy its influence on...
Colorectal cancer stands as a prevalent cause of cancer-related mortality, necessitating effective treatment strategies. Acute colonic obstruction occurs in approximately 20% patients and represents surgical emergency with substantial morbidity mortality. The optimal approach for managing left-sided colon acute remains debatable, no consensus on whether resection or bridge-to-surgery, involving initial decompressing stoma subsequent elective after recovery, should be employed. Current...
Abstract Introduction CRC with liver metastases is a major contributor to cancer-related mortality. Despite advancements in resection techniques, patient survival remains concern due high recurrence rates. This study seeks uncover prognostic biomarkers that predict overall patients undergoing curative hepatic for metastases. Methods Prospectively collected serum samples from cohort of 49 who received were studied. The are part cohort, previously analyzed perioperative complications (see...
Abstract Background Preoperative anaemia is a prevalent morbidity predictor that adversely affects short- and long-term outcomes of patients undergoing surgery. This analysis aimed to investigate preoperative its detrimental effects on after distal pancreatectomy. Material methods The present study was propensity-score match 286 consecutive Patients were screened for classified according WHO recommendations. primary outcome measure overall morbidity. secondary endpoints in-hospital mortality...
Abstract Introduction Early detection of severe complications may reduce morbidity and mortality in patients undergoing hepatic resection. Therefore, we prospectively evaluated a panel inflammatory blood markers for their value predicting postoperative liver surgery. Methods A total 139 resections (45 wedge resections, 49 minor 45 major resections) were enrolled between August 2017 December 2018. Leukocytes, CRP, neutrophil-lymphocyte ratio (NLR), thrombocyte-lymphocyte (TLR), bilirubin,...
Eine erfolgreiche chirurgische Behandlung ist ein entscheidender prognostischer Faktor in der von Patienten mit Kolonkarzinom. Dabei spielt die Versorgungsqualität behandelnden Klinik eine entscheidende Rolle. Zertifizierungen gelten als Qualitätssiegel für Umsetzung leitliniengerechter Behandlungsstrategien Versorgung Tumorerkrankungen. Die Studie untersucht Wirksamkeit chirurgischer eines Kolonkarzinoms Abhängigkeit des Qualitätsbewusstseins im Sinne einer Zertifizierung.
The influence of salt restriction for 3 months on blood pressure, peripheral vascular resistance (observed by occlusive plethysmography), erythrocyte sodium, platelet calcium, and pH, was studied in eight untreated essential hypertensive patients. A low diet decreases resistances, but not pH. strong positive correlation noted between baseline calcium resistances (r = 0.95, P less than .01). But during the period, a negative has been observed changes these parameters, which casts doubt use as...
Exosomes are nanosized membranous vesicles of endosomal origin. They released by cancer cells and transport RNA, DNA proteins their cellular have therefore gained increasing attention as non-invasive biomarkers in cancer. Glypcian-3 is a proteoglycan, which has been described tumor suppressor gene gastric Moreover, Glypican-3 shows decreased expression The value exosomal (eGCP-3) diagnostic prognostic biomarker patients with not investigated yet.
Exosome sind kleine ca. 30 – 100nm große Vesikel die von Zellen sezerniert werden und eine wichtige Rolle in der intrazellulären Verständigung spielen. Aktuelle Hinweise suggerieren Kommunikation zwichen Tumorzellen ihrem umgebenden Microenvironment. RAB27B ist ein Schlüsselprotein im Exosom-Pathway spielt entscheidende während Exosom-Sekretion. In vorliegenden Studie wurde Expression Pankreaskarzinomen auf deren Einfluss das Ansprechen Chemotherapie sowie Gesamtüberleben untersucht.