A5059718263- Multiple Myeloma Research and Treatments
- Cancer Treatment and Pharmacology
- Protein Degradation and Inhibitors
- Peptidase Inhibition and Analysis
- Trypanosoma species research and implications
- Research on Leishmaniasis Studies
- Sociology and Education Studies
- Respiratory viral infections research
- Influenza Virus Research Studies
- Asthma and respiratory diseases
- Acute Myeloid Leukemia Research
- Amyloidosis: Diagnosis, Treatment, Outcomes
- ATP Synthase and ATPases Research
- Family Dynamics and Relationships
- Mitochondrial Function and Pathology
- Virology and Viral Diseases
- Cancer therapeutics and mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Marriage and Sexual Relationships
- Hematological disorders and diagnostics
- Statistical Methods in Clinical Trials
- Protease and Inhibitor Mechanisms
- Hepatitis C virus research
- Cancer Immunotherapy and Biomarkers
- Vaccine Coverage and Hesitancy
German Cancer Research Center
2013-2024
Heidelberg University
2013-2024
Max Rubner Institut
2021-2024
Max Planck Society
2024
Max Planck Institute of Biophysics
2024
Medical University of Graz
2023
DKFZ-ZMBH Alliance
2019
Swiss Tropical and Public Health Institute
1989-2017
University of Basel
2017
Boehringer Ingelheim (Germany)
2015-2016
Bortezomib has become a cornerstone in the treatment of AL amyloidosis. In this study, we addressed prognostic impact cytogenetic aberrations for bortezomib-treated patients.We analyzed consecutive series 101 patients with amyloidosis treated bortezomib-dexamethasone as first-line by interphase fluorescence situ hybridization (iFISH). Patients were ineligible high-dose chemotherapy, which would put them at risk cardiac or renal failure, and thus represented poor-risk group.Presence t(11;14),...
Abstract Exposure to antibiotics in the first days of life is thought affect various physiological aspects neonatal development. Here, we investigate long-term impact antibiotic treatment period and early childhood on child growth an unselected birth cohort 12,422 children born at full term. We find significant attenuation weight height gain during 6 years after exposure boys, but not girls, adjusting for potential confounders. In contrast, use associated with significantly higher body mass...
Treatment of Human African Trypanosomiasis (HAT or sleeping sickness) relies on a few drugs which are old, toxic and expensive. The most important drug for the treatment second stage infection is melarsoprol. During last 50 years failures with melarsoprol were not major problem in Trypanosoma brucei gambiense patients. Commonly relapse rate 5–8% was reported, but recent it has increased dramatically some foci T. b. sickness. rhodesiense much less apart from reports between 1960 1985...
The aim of this trial was to investigate the addition anti-SLAMF7 monoclonal antibody elotuzumab lenalidomide, bortezomib, and dexamethasone (RVd) in induction consolidation therapy as well lenalidomide maintenance treatment transplant-eligible patients with newly diagnosed multiple myeloma.
Journal Article Differential regulation of plasminogen activator and inhibitor gene transcription by the tumor suppressor p53 Get access Christina Kunz, Kunz Haemostasis Research Unit, Kerckhoff-Klinik, Max-Planck-InstitutSprudelhof 11, D-61231 Bad Nauheim, Germany Search for other works this author on: Oxford Academic PubMed Google Scholar Stefanie Pebler, Pebler Jürgen Otte, Otte Dietmar von der Ahe * *To whom correspondence should be addressed Nucleic Acids Research, Volume 23, Issue 18,...
Chromosomal aberrations of plasma cells are well established pathogenetic and prognostic factors in multiple myeloma, but their implication systemic light chain (AL) amyloidosis is unclear. Therefore, the aim this study was to identify cytogenetic risk by interphase FISH a series 103 consecutive AL patients treated uniformly with melphalan/dexamethasone as first-line therapy. Detection gain 1q21 predictive for poor overall survival (OS) (median 12.5 versus 38.2 months, p = 0.002)....
In acute myeloid leukemia (AML), studies based on whole-genome sequencing have shown genomic diversity within leukemic clones. The aim of this study was to address clonal heterogeneity in AML metaphase cytogenetics.This analysis included all patients enrolled onto two consecutive, prospective, randomized multicenter trials the Study Alliance Leukemia. Patients were newly diagnosed with non-M3 and fit for intensive chemotherapy.Cytogenetic subclones detected 418 (15.8%) 2,639 from whole...
We investigated the impact of subcutaneous versus intravenous bortezomib in MM5 trial German-Speaking Myeloma Multicenter Group which compared bortezomib, doxorubicin, and dexamethasone with cyclophosphamide, induction therapy newly diagnosed multiple myeloma. Based on data from relapsed myeloma, route administration for was changed to after 314 604 patients had been enrolled. analyzed 598 who received at least one dose medication. Adverse events were reported more frequently treated...
Cells depend on a continuous supply of adenosine triphosphate (ATP), the universal energy currency. In mitochondria, ATP is produced by series redox reactions, whereby an electrochemical gradient established across inner mitochondrial membrane. The synthase harnesses to generate from diphosphate (ADP) and inorganic phosphate. We determined structure within mitochondria unicellular flagellate
During the last years, a strong increase in sales volume and consumption of plant-based drinks was observed, which were partly used as an alternative to cow's milk. As milk is relevant protein source many countries, we have investigated bioaccessibility digestibility soy, almond, oat comparison using tiny-TIMsg gastrointestinal model. The relative all products between 81% (soy drink) 90% (milk). digestible indispensable amino acid score (DIAAS) vitro method estimate nutritional quality....
Respiratory syncytial virus (RSV) usually causes self-limiting upper respiratory tract infections, but can be associated with severe lower infection disease (LRTID) in infants and patients hematologic malignancies. We have analyzed the risk factors measures for containment within an outbreak of nosocomial RSV infections a hematology SCT unit. A total 56 were affected (53 RSV-A 3 RSV-B) including 32 transplant (16 allogeneic 16 autologous). Forty (71%) suffered from LRTID 14 (35%)...
Abstract Lenalidomide (LEN) maintenance (MT) post autologous stem cell transplantation (ASCT) is standard of care in newly diagnosed multiple myeloma (MM) but has not been compared to other agents clinical trials. We retrospectively bortezomib (BTZ; n = 138) or LEN ( 183) MT from two subsequent GMMG phase III All patients received three cycles BTZ-based triplet induction and post-ASCT MT. BTZ (1.3 mg/m 2 i.v.) was administered every weeks for years. included consolidation (25 mg p.o., days...
To noninvasively assess bone marrow microcirculation before and after therapy in patients with newly diagnosed multiple myeloma dynamic contrast-enhanced MRI (DCE-MRI).Ninety-six received DCE-MRI primary treatment for myeloma. For the 91 evaluable patients, consisted of high-dose (HDT) autologous stem cell transplantation (ASCT) 82 chemotherapy without ASCT 9 patients. In addition, 33 healthy volunteers were imaged as control group. Analysis was performed according to two-compartment model...