A5060145077- Influenza Virus Research Studies
- Respiratory viral infections research
- Health and Medical Studies
- COVID-19 epidemiological studies
- Legionella and Acanthamoeba research
- Infection Control and Ventilation
- SARS-CoV-2 and COVID-19 Research
- COVID-19 and Mental Health
- Pneumonia and Respiratory Infections
- Viral gastroenteritis research and epidemiology
- Vaccine Coverage and Hesitancy
- Data-Driven Disease Surveillance
- SARS-CoV-2 detection and testing
- Travel-related health issues
- Viral Infections and Outbreaks Research
- Pediatric health and respiratory diseases
- Salmonella and Campylobacter epidemiology
- Escherichia coli research studies
- Food Safety and Hygiene
- Antimicrobial Resistance in Staphylococcus
- Viral Infections and Vectors
- COVID-19 and healthcare impacts
- Medical Practices and Rehabilitation
- Animal Disease Management and Epidemiology
- Immune responses and vaccinations
Robert Koch Institute
2014-2024
European Centre for Disease Prevention and Control
2021-2024
Stockholm University
2021
University of Hong Kong
2014
München Klinik Schwabing
2014
University of Bonn
2014
Charité - Universitätsmedizin Berlin
2010
Centers for Disease Control and Prevention
1998-2002
Los Angeles County Department of Health Services
2000-2002
Epidemic Intelligence Service
1999-2002
We describe an outbreak of gastroenteritis and the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli in Germany May, June, July, 2011. The consumption sprouts was identified as most likely vehicle infection.We analyzed data from reports E. clinical information on patients presenting to Hamburg University Medical Center (HUMC). An case defined a reported or patient infected coli, serogroup O104 unknown, with onset disease during period May 1 through July 4, 2011,...
A large outbreak of the hemolytic-uremic syndrome caused by Shiga-toxin-producing Escherichia coli O104:H4 occurred in Germany May 2011. The source infection was undetermined.We conducted a matched case-control study and recipe-based restaurant cohort study, along with environmental, trace-back, trace-forward investigations, to determine infection.The included 26 case subjects 81 control subjects. illness associated sprout consumption univariable analysis (matched odds ratio, 5.8; 95%...
Abstract In Europe, antimicrobial resistance has been monitored since 1998 by the European Antimicrobial Resistance Surveillance System (EARSS). We examined relationship between penicillin nonsusceptibility of invasive isolates Streptococcus pneumoniae (an indicator organism) and antibiotic sales. Information was collected on 1998-99 data for S. to penicillin, based surveillance from EARSS outpatient sales during 1997 beta-lactam antibiotics macrolides. Our results show that in Europe is...
In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a disease presenting with fever, cough, and often pneumonia. WHO has set strategic objective to interrupt spread of SARS-CoV-2 worldwide. An outbreak Bavaria, Germany, starting at end January, 2020, provided opportunity study transmission events, incubation period, secondary attack rates.
Mitigation of the coronavirus disease (COVID-19) pandemic in Germany included school closures early March 2020. After reopening April, preventive measures were taken schools. We analysed national surveillance system data on COVID-19 outbreaks during different time periods. reopening, smaller (average: 2.2/week) occurred despite low incidence general population. School might have a detrimental effect children and should be applied only cautiously combination with other measures.
Previous controlled studies on the effect of non-pharmaceutical interventions (NPI) - namely use facemasks and intensified hand hygiene in preventing household transmission influenza have not produced definitive results. We aimed to investigate efficacy, acceptability, tolerability NPI households with index patients.We conducted a cluster randomized trial during pandemic season 2009/10 ensuing 2010/11. included an positive case absence further respiratory illness within preceding 14 days....
On 24 October 2012, a patient with acute respiratory distress syndrome of unknown origin and symptom onset on 5 was transferred from Qatar to specialist lung clinic in Germany. Late diagnosis 20 November an infection the novel Coronavirus (NCoV) resulted potential exposure considerable number healthcare workers. Using questionnaire we asked 123 identified contacts (120 hospital three out-of-hospital contacts) about patient. Eighty-five provided blood for serological test using two-stage...
Since the 2008/9 influenza season, I-MOVE multicentre case–control study measures vaccine effectiveness (VE) against medically-attended influenza-like-illness (ILI) laboratory confirmed as influenza. In 2011/12, European studies reported a decline in VE A(H3N2) within season. Using combined data from 2010/11 to 2014/15 we studied effects of time since vaccination on type/subtype-specific VE. We modelled by using restricted cubic spline, controlling for potential confounders (age, sex, onset,...
Background Influenza viral shedding studies provide fundamental information for preventive strategies and modelling exercises. We conducted a prospective household study to investigate in seasonal pandemic influenza between 2007 2011 Berlin Munich, Germany. Methods Study physicians recruited index patients their members. Serial nasal specimens were obtained from all members over at least eight days tested quantitatively by qRT-PCR the virus (sub)type of patient. A subset samples was also...
We investigated three SARS-CoV-2 variant B.1.1.7 childcare centre and related household outbreaks. Despite group cohorting, cases occurred in almost all groups, i.e. also among persons without close contact. Children's secondary attack rates (SAR) were similar to adults (childcare centres: 23% vs 30%; p = 0.15; households: 32% 39%; 0.27); child- adult-induced outbreaks led SAR. With the advent of B.1.1.7, susceptibility infectiousness children seem converge. Public health measures should be...
In May 2003 the Soest County Health Department was informed of an unusually large number patients hospitalized with atypical pneumonia.In exploratory interviews mentioned having visited a farmers' market where sheep had lambed. Serologic testing confirmed diagnosis Q fever. We asked local health departments in Germany to identify notified fever who farmers market. To investigate risk factors for infection we conducted case control study (cases were patients, controls randomly selected...
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Essential epidemiologic and virologic parameters must be measured to provide evidence for policy/public health recommendations mathematical modeling concerning novel influenza A/H1N1 virus (NIV) infections. Therefore, from April through August of 2009, the authors collected nasopharyngeal specimens information on antiviral medication symptoms households with NIV infection a daily basis in Germany. Specimens were analyzed quantitatively by using reverse transcriptase-polymerase chain...
In the spring of 2000, a cluster indistinguishable Shiga toxin–producing Escherichia coli (STEC) O26:H11 was identified in Germany by molecular subtyping surveillance. An investigation prompted to identify common source exposure. A case subject defined as person having polymerase chain reaction–confirmed STEC O26 infection between March and April irrespective clinical signs, whose isolate from index strain use pulsed-field gel electrophoresis. Eleven subjects were found 5 institutions that...
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Influenza immunisation for healthcare workers is encouraged to protect their often vulnerable patients but also due a perceived higher risk influenza. We aimed compare the of influenza infection in acute hospital care with that non-healthcare over same season.We conducted prospective, multicentre cohort study during 2006/07 season Berlin, Germany. Recruited participants gave serum samples before and after season, completed questionnaires determine relevant exposures possible confounding...
Respiratory syncytial virus (RSV) usually causes self-limiting upper respiratory tract infections, but can be associated with severe lower infection disease (LRTID) in infants and patients hematologic malignancies. We have analyzed the risk factors measures for containment within an outbreak of nosocomial RSV infections a hematology SCT unit. A total 56 were affected (53 RSV-A 3 RSV-B) including 32 transplant (16 allogeneic 16 autologous). Forty (71%) suffered from LRTID 14 (35%)...
Abstract Currently, the respiratory route is seen as most important transmission path for SARS-CoV-2. In this investigation, models of other researchers which had aim predicting an infection risk exposed persons in a room through aerosols emitted by infectious case-patient were extended. As novelty – usually neglected parameters or boundary conditions, namely non-stationarity and half-life aerosolized virus, included new method determining quanta emission rate based on measurements particle...
Abstract We determined secondary attack rates (SAR) among close contacts of 59 asymptomatic and symptomatic coronavirus disease case-patients by presymptomatic exposure. observed no transmission from highest SAR through Rapid quarantine with or without symptoms is needed to prevent transmission.
Abstract Background During the SARS-CoV-2 pandemic, German early childhood education and care (ECEC) centres organised children’s attendance in different ways, they reduced opening hours, provided emergency support for a few children, or closed completely. Further, protection hygiene measures like fixed children-staff groups, ventilation surface disinfection were introduced ECEC centres. To inform modify public health ECEC, we investigate occurrence of infections among children staff light...