A5048574559- Viral gastroenteritis research and epidemiology
- Respiratory Support and Mechanisms
- Animal Virus Infections Studies
- Helicobacter pylori-related gastroenterology studies
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Viral Infections and Immunology Research
- Cardiac Arrest and Resuscitation
- Herpesvirus Infections and Treatments
- Hepatitis Viruses Studies and Epidemiology
- Data-Driven Disease Surveillance
- Respiratory viral infections research
- Salmonella and Campylobacter epidemiology
- Viral Infections and Outbreaks Research
- Eosinophilic Esophagitis
- Health and Medical Studies
- Pneumonia and Respiratory Infections
- Neuroscience of respiration and sleep
- Intensive Care Unit Cognitive Disorders
- Influenza Virus Research Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Mechanical Circulatory Support Devices
- Gastric Cancer Management and Outcomes
- Viral Infections and Vectors
RWTH Aachen University
2016-2025
GlaxoSmithKline (Belgium)
2007-2024
Universitätsklinikum Aachen
2015-2024
University of Tübingen
2020
KU Leuven
2018
University Children's Hospital Tübingen
2014
Hochschule Bonn-Rhein-Sieg
2011-2013
GlaxoSmithKline (United Kingdom)
2005-2012
GlaxoSmithKline (Netherlands)
2004-2012
GlaxoSmithKline (India)
2008
The safety and efficacy of an attenuated G1P[8] human rotavirus (HRV) vaccine were tested in a randomized, double-blind, phase 3 trial.We studied 63,225 healthy infants from 11 Latin American countries Finland who received two oral doses either the HRV (31,673 infants) or placebo (31,552 at approximately months four age. Severe gastroenteritis episodes identified by active surveillance. severity disease was graded with use 20-point Vesikari scale. Vaccine evaluated subgroup 20,169 (10,159...
Coronavirus-like particles (CoVLP) that are produced in plants and display the prefusion spike glycoprotein of original strain severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) combined with an adjuvant (Adjuvant System 03 [AS03]) to form candidate vaccine.In this phase 3, multinational, randomized, placebo-controlled trial conducted at 85 centers, we assigned adults (≥18 years age) a 1:1 ratio receive two intramuscular injections CoVLP+AS03 vaccine or placebo 21 days apart. The...
In the summer of 1998, a large outbreak Escherichia coli O157:H7 infections occurred in Alpine, Wyoming. We identified 157 ill persons; stool from 71 (45%) yielded E. O157:H7. two cohort studies, illness was significantly associated with drinking municipal water (town residents: adjusted odds ratio=10.1, 95% confidence intervals [CI]=1.8-56.4; visitors attending family reunion: relative risk=9.0, CI=1.3-63.3). The unchlorinated supply had microbiologic evidence fecal organisms and potential...
A pooled analysis of the safety human papillomavirus (HPV)-16/18 AS04-adjuvanted cervical cancer vaccine Cervarix™ (GlaxoSmithKline) was performed in a cohort almost 30000 girls and women aged ≥10 years, 16142 who received at least one dose HPV-16/18 13811 three controls [Al(OH)3 or hepatitis (720 360 EU)]. Data are available for total 45988 doses. Solicited local general symptoms were recorded 7 days after each dose. Serious adverse events (SAEs), pregnancies, medically significant...
Background: Mexico initiated mass vaccination with the attenuated human rotavirus vaccine (Rotarix) in 2006. This postlicensure study aimed to assess any potential temporal association between and intussusception Mexican infants. Methods: Prospective, active surveillance for among infants aged less than 1 year was conducted 221 hospitals across from Institute of Social Security January 2008 October 2010. The assessed by self-controlled case-series analysis. Results: Of 753 episodes reported...
A multistate outbreak of Escherichia coli O157:H7 infections occurred in the United States June and July 1997. Two concurrent outbreaks were investigated through independent case-control studies Michigan Virginia by subtyping isolates with pulsed-field gel electrophoresis (PFGE). Isolates from 85 persons indistinguishable PFGE. Alfalfa sprouts only exposure associated E. infection both Virginia. Seeds used for sprouting traced back to one common lot harvested Idaho. New tools such as PFGE...
This study sought to assess the risk of secondary transmission after import Lassa fever into Europe. A total 232 persons exposed a case imported Germany were identified. The level exposure was determined for 157 (68%), and 149 (64%) tested serologically. High-risk or close contact reported by 30 (19%) persons. No symptomatic infections observed. However, virus-specific immunoglobulin G antibodies detected in serum sample obtained from physician who examined index patient on day 9 illness....
In a parallel-group, international, phase 3 study (ClinicalTrials.govNCT04762680), we evaluated prototype (D614) and Beta (B.1.351) variant recombinant spike protein booster vaccines with AS03-adjuvant (CoV2 preS dTM-AS03).Adults, previously primed mRNA (BNT162b2, mRNA-1273), adenovirus-vectored (Ad26.CoV2.S, ChAdOx1nCoV-19) or dTM-AS03 [monovalent D614; MV(D614)]) were enrolled between 29 July 2021 22 February 2022. Participants stratified by age (18-55 ≥ 56 years) received one of the...
In the spring of 2000, a cluster indistinguishable Shiga toxin–producing Escherichia coli (STEC) O26:H11 was identified in Germany by molecular subtyping surveillance. An investigation prompted to identify common source exposure. A case subject defined as person having polymerase chain reaction–confirmed STEC O26 infection between March and April irrespective clinical signs, whose isolate from index strain use pulsed-field gel electrophoresis. Eleven subjects were found 5 institutions that...
Salmonella infections due to contaminated food products make many people ill each year and are responsible for substantial economic costs. potentially serious may be fatal, particularly the elderly with weak immune systems (see box on infections). However, most salmonellosis cases do not result in a visit medical facility never reported public health agencies. The high proportion of unreported makes it difficult determine true incidence salmonellosis, has resulted wide range estimates annual...
In 2001 Germany implemented a new electronic reporting system for surveillance of notifiable infectious diseases (SurvNet@RKI). The is currently being used in all 431 local health departments (LHD), the 16 state (SHD) and Robert Koch-Institut (RKI), national agency disease epidemiology. SurvNet@RKI software written MS Access 97 Visual Basic it supports as well SQL Server database management systems back-end. designed distributed, dynamic 73 categories with more than 600 fields about 7000...
<h3>Objective:</h3> Varicella vaccination was introduced at the end of 1999 into Uruguayan immunisation schedule for children aged 12 months. <i>Varilrix</i> (Oka strain; GlaxoSmithKline Biologicals) has been only vaccine used since then and coverage estimated to exceed 90% start universal varicella programme. We assessed impact programme during 2005, 6 years after its introduction. <h3>Methods:</h3> Information on hospitalisations collected from main paediatric referral hospital information...
Introduction: Extending the benefits of vaccination against infectious diseases from childhood throughout entire life-span is becoming an increasingly urgent priority in view world's aging population, emergence and reemergence diseases, necessity to invest more on prevention versus cure global healthcare.Areas covered: This perspective discusses how life-course immunization could benefit human health at all stages life. To achieve this, current paradigm should be changed stakeholders have a...
The association between rotavirus serotypes and severity is not well established. Analysis of a clinical trial conducted in Latin America points at more-severe disease associated with serotype G9. Thus, demonstration efficacy against G9 will be an important asset any vaccine to introduced into American country or where has been shown prevalent.
OBJECTIVES: To estimate the costs, benefits and cost-effectiveness of vaccination for rotavirus gastroenteritis in eight Latin American Caribbean countries: Argentina, Brazil, Chile, Dominican Republic, Honduras, Mexico, Panama, Venezuela. METHODS: An economic model was constructed to from health care system perspective, using national administrative published epidemiological evidence, country-specific cost estimates, vaccine efficacy data. The applied first five years life 2003 birth cohort...
Abstract Background Some vaccines elicit nonspecific immune responses that may protect against heterologous infections. We evaluated the association between recombinant adjuvanted zoster vaccine (RZV) and coronavirus disease 2019 (COVID-19) outcomes at Kaiser Permanente Southern California. Methods In a cohort design, adults aged ≥50 years who received ≥1 RZV dose before 1 March 2020 were matched 1:2 to unvaccinated individuals followed until 31 December 2020. Adjusted hazard ratios (aHRs)...