Tyra Grove Krause
A5065031002- Influenza Virus Research Studies
- SARS-CoV-2 and COVID-19 Research
- COVID-19 epidemiological studies
- COVID-19 Clinical Research Studies
- Respiratory viral infections research
- SARS-CoV-2 detection and testing
- Vaccine Coverage and Hesitancy
- COVID-19 and healthcare impacts
- Climate Change and Health Impacts
- Pneumonia and Respiratory Infections
- COVID-19 and Mental Health
- Immune responses and vaccinations
- Bacterial Infections and Vaccines
- COVID-19 diagnosis using AI
- Receptor Mechanisms and Signaling
- Asthma and respiratory diseases
- Virology and Viral Diseases
- Health disparities and outcomes
- Data-Driven Disease Surveillance
- Neonatal Respiratory Health Research
- Animal Virus Infections Studies
- Viral Infections and Outbreaks Research
- Long-Term Effects of COVID-19
- COVID-19 Impact on Reproduction
- Immune Response and Inflammation
Statens Serum Institut
2016-2025
European Centre for Disease Prevention and Control
2022
University of Copenhagen
2022
Imperial College London
2022
Nordsjællands Hospital
2022
Omron (Japan)
2022
Delta Air Lines (United States)
2022
Queen Ingrid's Hospital
2011
Universität Greifswald
2002
Danish National Research Foundation
2001
Population-level knowledge on individuals at high risk of severe and fatal coronavirus disease 2019 (COVID-19) is urgently needed to inform targeted protection strategies in the general population.We examined characteristics predictors hospitalization death a nationwide cohort all Danish tested for acute respiratory syndrome 2 (SARS-CoV-2) from 27 February 2020 until 19 May 2020.We identified 11 122 SARS-CoV-2 polymerase chain reaction-positive cases whom 80% were community-managed 20%...
A remarkable excess mortality has coincided with the COVID-19 pandemic in Europe. We present preliminary pooled estimates of all-cause for 24 European countries/federal states participating monitoring public health action (EuroMOMO) network, period March–April 2020. Excess particularly affected ≥ 65 year olds (91% all deaths), but also 45–64 (8%) and 15–44 (1%). No was observed 0–14 olds.
1 Abstract The Omicron SARS-CoV-2 variant of concern (VOC lineage B.1.1.529), which became dominant in many countries during early 2022, includes several subvariants with strikingly different genetic characteristics. Several countries, including Denmark, have observed the two subvariants: BA.1 and BA.2. In Denmark latter has rapidly replaced former as subvariant. Based on nationwide Danish data, we estimate transmission dynamics BA.2 following spread VOC within households late December 2021...
By 9 December 2021, 785 SARS-CoV-2 Omicron variant cases have been identified in Denmark. Most were fully (76%) or booster-vaccinated (7.1%); 34 (4.3%) had a previous infection. The majority of with available information reported symptoms (509/666; 76%) and most infected Denmark (588/644; 91%). One five cannot be linked to cases, indicating widespread community transmission. Nine hospitalised, one required intensive care no deaths registered.
In 2014, Denmark experienced a rapid decline in vaccination uptake for the human papillomavirus (HPV) vaccine after successful introduction of 2009. Before decline, first HPV was around 90% girls born period 1998 to 2000, while it dropped 54% 2003. The followed negative public attention from 2013 coinciding with increasing suspected adverse-event reporting Danish Medicines Agency. aim this study is describe HPV-vaccination uptake, quantify relevant HPV-related media coverage, and analyse...
1 Abstract The Omicron variant of concern (VOC) is a rapidly spreading SARS-CoV-2 that likely to overtake the previously dominant Delta VOC in many countries by end 2021. We estimated transmission dynamics following spread within Danish households during December used data from registers estimate household secondary attack rate (SAR). Among 11,937 (2,225 with VOC), we identified 6,397 infections 1-7 day follow-up period. SAR was 31% and 21% VOC, respectively. found an increased for...
ABSTRACT In this brief communication we are showing original research results with early estimates from Danish nationwide databases of vaccine effectiveness (VE) against the novel SARS-CoV-2 Omicron variant (B.1.1.529) up to five months after a primary vaccination series BNT162b2 or mRNA-1273 vaccines. Our study provides evidence protection infection completion vaccines; in particular, found VE 55.2% (95% confidence interval (CI): 23.5 73.7%) and 36.7% CI: -69.9 76.4%) for vaccines,...
The more infectious SARS-CoV-2 lineage B.1.1.7 rapidly spread in Europe after December, 2020, and a concern that could cause severe disease has been raised. Taking advantage of Denmark's high RT-PCR testing whole genome sequencing capacities, we used national health register data to assess the risk COVID-19 hospitalisation individuals infected with compared those other lineages.We did an observational cohort study all SARS-CoV-2-positive cases confirmed by Denmark, sampled between Jan 1...
In June-November 2020, SARS-CoV-2-infected mink were detected in 290 of 1,147 Danish farms. North Denmark Region, 30% (324/1,092) people found connected to farms tested SARS-CoV-2-PCR-positive and approximately 27% (95% confidence interval (CI): 25-30) SARS-CoV-2-strains from humans the community mink-associated. Measures proved insufficient mitigate spread. On 4 November, government ordered culling all mink. Farmed constitute a potential virus reservoir challenging pandemic control.
SARS coronavirus 2 (SARS-CoV-2) continues to evolve and new variants emerge. Using nationwide Danish data, we estimate the transmission dynamics of SARS-CoV-2 Omicron subvariants BA.1 BA.2 within households. Among 22,678 primary cases, identified 17,319 secondary infections among 50,588 household contacts during a 1-7 day follow-up. The attack rate (SAR) was 29% 39% in households infected with BA.2, respectively. associated increased susceptibility infection for unvaccinated (Odds Ratio (OR)...
Abstract In late 2021, the Omicron SARS-CoV-2 variant overtook previously dominant Delta variant, but extent to which this transition was driven by immune evasion or a change in inherent transmissibility is currently unclear. We estimate transmission within Danish households during December 2021. Among 26,675 (8,568 with VOC), we identified 14,140 secondary infections 1–7-day follow-up period. The attack rate 29% and 21% infected Delta, respectively. For Omicron, odds of infection were 1.10...
Abstract The newly found Omicron SARS-CoV-2 variant of concern has rapidly spread worldwide. carries numerous mutations in key regions and is associated with increased transmissibility immune escape. recently been divided into four subvariants substantial genomic differences, particular between BA.1 BA.2. With the surge BA.2, a large number reinfections from earlier cases observed, raising question whether BA.2 specifically can escape natural immunity acquired shortly after infection. To...
We describe 10 cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant BA.2.86 detected in Denmark, including molecular characteristics and results from wastewater surveillance that indicate the is circulating country at a low level. This new with many spike gene mutations was classified as under monitoring by World Health Organization on 17 August 2023. Further global COVID-19, other SARS-CoV-2 variants highly warranted.
We report a surge of patients, especially children and adolescents, with respiratory disease caused by
In low-income countries, live measles vaccine reduces mortality from causes other than infection. Such nonspecific effects of vaccines might also be important for the health children in high-income settings.To examine whether against measles, mumps, and rubella (MMR) is associated with lower rates hospital admissions infections among Denmark.Population-based cohort study Danish born 1997-2006 followed up ages 11 months to 2 years (last follow-up, August 31, 2008). Nationwide registers...
Immunisation information systems (IIS) are valuable tools for monitoring vaccination coverage and estimating vaccine effectiveness safety. Since 2009, an advanced IIS has been developed in Denmark will be implemented during 2012–14. This is based on a database existing since 2000. The reporting of all administered vaccinations including outside the national programme become mandatory. Citizens get access to data about their own healthcare personnel patients. A concept identification,...
<h3>Context</h3>Assessment of the fetal safety vaccination against influenza A(H1N1)pdm09 in pregnancy has been limited.<h3>Objective</h3>To investigate whether exposure to an adjuvanted vaccine during was associated with increased risk adverse outcomes.<h3>Design, Setting, and Participants</h3>Registry-based cohort study based on all liveborn singleton infants Denmark, delivered between November 2, 2009, September 30, 2010. In propensity score–matched analyses, we estimated prevalence odds...
<b>Objective</b> To investigate whether an adjuvanted pandemic A/H1N1 2009 influenza vaccine in pregnancy was associated with increased risk of fetal death. <b>Design</b> Nationwide register based cohort study. <b>Setting</b> Denmark. <b>Participants</b> All clinically recognised singleton pregnancies that ended between November and September 2010. Individual level data on exposure to inactivated AS03 (Pandemrix) potential confounders were linked the study using a unique person identifier....
Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high mortality during influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe and influenza-attributable season in Europe.Based on weekly reporting from 24 countries or sub-national regions, representing 60% population excluding Russian Turkish parts Europe, we estimated age stratified morality using model. In addition, was FluMOMO algorithm, incorporating activity...
Since December 2016, excess all-cause mortality was observed in many European countries, especially among people aged ≥ 65 years. We estimated and influenza-attributable 19 countries/regions. Excess primarily explained by circulation of influenza virus A(H3N2). Cold weather snaps contributed some countries. The pattern similar to the last major A(H3N2) season 2014/15 Europe, although starting earlier line with early start.