A5046772961- Diabetes Treatment and Management
- Heart Failure Treatment and Management
- Potassium and Related Disorders
- Pregnancy and Medication Impact
- Inflammatory Bowel Disease
- Microscopic Colitis
- Gastroesophageal reflux and treatments
- Medication Adherence and Compliance
- Influenza Virus Research Studies
- Cardiac electrophysiology and arrhythmias
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac pacing and defibrillation studies
- Neuroendocrine Tumor Research Advances
- Peripheral Neuropathies and Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Metabolism, Diabetes, and Cancer
- Cardiovascular Effects of Exercise
- Electrolyte and hormonal disorders
- Acute Lymphoblastic Leukemia research
- Cardiovascular Issues in Pregnancy
- Pneumonia and Respiratory Infections
- Respiratory viral infections research
- Traumatic Brain Injury Research
- Sports injuries and prevention
- Peptidase Inhibition and Analysis
Statens Serum Institut
2015-2024
Karolinska Institutet
2018-2024
IQVIA (United States)
2023
Karolinska University Hospital
2018
Danish Medicines Agency
2011
The composition of the intestinal microflora has been proposed as an important factor in development inflammatory bowel diseases (IBD). Antibiotics have potential to alter microflora. A study was undertaken evaluate association between use antibiotics and IBD childhood.A nationwide cohort conducted all Danish singleton children born from 1995 2003 (N=577,627) with individual-level information on filled antibiotic prescriptions, confounding variables. Using Poisson regression, rate ratios...
Abstract Objective To assess the association between use of sodium glucose cotransporter 2 (SGLT2) inhibitors and seven serious adverse events current concern. Design Register based cohort study. Setting Sweden Denmark from July 2013 to December 2016. Participants A propensity score matched 17 213 new users SGLT2 (dapagliflozin, 61%; empagliflozin, 38%; canagliflozin, 1%) active comparator, glucagon-like peptide 1 (GLP1) receptor agonists. Main outcome measures The primary outcomes were...
<h3>Objective</h3> The use of cone beam imaging during neurointerventional procedure has been increasing rapidly. Initially used as a CT-scan for evaluation intra-procedural complications such hemorrhage, it evolved to provide details implanted devices flow diverters. aim this study is present our experience using CTA with intra-arterial injection and step-by-step approach post-processing in practical protocol daily use. <h3>Methods</h3> After institutional IRB approval was obtained, the...
A Cochrane review and network meta-analysis concluded that there is need for more research on adverse effects, including cancer, after treatment with tumor necrosis factor α (TNF-α) antagonists national registries large databases would provide relevant sources of data to evaluate these effects.To investigate whether patients inflammatory bowel disease (IBD) exposed TNF-α were at increased risk developing cancer.Nationwide register-based cohort study in Denmark, 1999-2012. Participants 56,146...
Azithromycin use is associated with an increased risk of death from cardiovascular causes among patients at high baseline risk. Whether azithromycin confers a similar in the unselected general population unknown.
<h3>Abstract</h3> <h3>Objective</h3> To investigate whether oral fluoroquinolone use is associated with an increased risk of aortic aneurysm or dissection. <h3>Design</h3> Nationwide historical cohort study using linked register data on patient characteristics, filled prescriptions, and cases <h3>Setting</h3> Sweden, July 2006 to December 2013. <h3>Participants</h3> 360 088 treatment episodes (78%<b></b>ciprofloxacin) propensity score matched comparator amoxicillin (n=360 088). <h3>Main...
Increased risks of lymphoma and skin cancer associated with thiopurine use among patients inflammatory bowel disease have been shown, but data on the overall risk are limited. We conducted a historical cohort study 45,986 (of whom, 5,197 (11%) used azathioprine) in Denmark from 1997 to 2008. linked registry filled drug prescriptions, diagnoses, covariates compared rates incident subgroups between users nonusers azathioprine, adjusting for propensity scores. During median 7.9 (interquartile...
Football (soccer) players might be at increased risk of neurodegenerative disease, which has led to questions regarding the safety sport and recent measures introduced by football associations reduce heading ball. We aimed assess disease among male in Swedish top division Allsvenskan, compared with matched controls.In this cohort study, we identified all (amateurs professionals) who had played least one game Allsvenskan from Aug 1, 1924 Dec 31, 2019 excluded whose personal identity number...
Abstract Objective To investigate whether use of glucagon-like peptide 1 (GLP1) receptor agonists is associated with increased risk thyroid cancer. Design Scandinavian cohort study. Setting Denmark, Norway, and Sweden, 2007-21. Participants Patients who started GLP1 agonist treatment were compared patients dipeptidyl peptidase 4 (DPP4) inhibitor treatment, in an additional analysis, sodium-glucose cotransporter 2 (SGLT2) treatment. Main outcome measures Thyroid cancer identified from...
Ondansetron is frequently used to treat nausea and vomiting during pregnancy, but the safety of this drug for fetus has not been well studied.We investigated risk adverse fetal outcomes associated with ondansetron administered pregnancy. From a historical cohort 608,385 pregnancies in Denmark, women who were exposed those included, 1:4 ratio, propensity-score-matched analyses spontaneous abortion (1849 vs. 7396 unexposed women), stillbirth (1915 7660), any major birth defect (1233 4932),...
<h3>Importance</h3> Case reports have suggested a link between human papillomavirus (HPV) vaccination and development of multiple sclerosis other demyelinating diseases. <h3>Objective</h3> To investigate if quadrivalent HPV (qHPV) is associated with an increased risk <h3>Design, Setting, Participants</h3> Using nationwide registers we identified cohort all females aged 10 years to 44 in Denmark Sweden, followed up from 2006 2013, information on qHPV vaccination, data incident diagnoses The...
Experimental evidence and case-control studies suggest that dihydropyridine calcium channel blockers (DiCCBs) may protect against Parkinson's disease. The authors conducted a historical cohort study in Denmark to investigate the association between DiCCB use risk of disease (1998–2006). Individual-level data on filled drug prescriptions, diagnostic information, covariates were linked nationwide registries. Among users, 173 incident cases detected during 461,984 person-years follow-up,...
<h3>Context</h3>Assessment of the fetal safety vaccination against influenza A(H1N1)pdm09 in pregnancy has been limited.<h3>Objective</h3>To investigate whether exposure to an adjuvanted vaccine during was associated with increased risk adverse outcomes.<h3>Design, Setting, and Participants</h3>Registry-based cohort study based on all liveborn singleton infants Denmark, delivered between November 2, 2009, September 30, 2010. In propensity score–matched analyses, we estimated prevalence odds...
<b>Objective</b> To investigate whether an adjuvanted pandemic A/H1N1 2009 influenza vaccine in pregnancy was associated with increased risk of fetal death. <b>Design</b> Nationwide register based cohort study. <b>Setting</b> Denmark. <b>Participants</b> All clinically recognised singleton pregnancies that ended between November and September 2010. Individual level data on exposure to inactivated AS03 (Pandemrix) potential confounders were linked the study using a unique person identifier....
Vaginal candidiasis is common during pregnancy. Although intravaginal formulations of topical azole antifungals are first-line treatment for pregnant women, oral fluconazole often used despite limited safety information.To study the association between exposure pregnancy and risk spontaneous abortion stillbirth.Nationwide register-based cohort in Denmark, 1997-2013. From a 1,405,663 pregnancies, fluconazole-exposed pregnancies were compared with up to 4 unexposed matched on propensity score,...
Abstract Objective To investigate the cardiovascular effectiveness of sodium glucose cotransporter 2 (SGLT2) inhibitors in routine clinical practice. Design Cohort study using data from nationwide registers and an active-comparator new-user design. Setting Denmark, Norway, Sweden, April 2013 to December 2016. Participants 20 983 new users SGLT2 dipeptidyl peptidase 4 (DPP4) inhibitors, aged 35-84, matched by age, sex, history major disease, propensity score. Main outcome measures Primary...
Abstract Objective To assess the association between use of sodium-glucose co-transporter 2 (SGLT2) inhibitors and risk serious renal events in data from routine clinical practice. Design Cohort study using an active comparator, new user design nationwide register data. Setting Sweden, Denmark, Norway, 2013-18. Participants 29 887 users SGLT2 (follow-up time: dapagliflozin 66.1%; empagliflozin 32.6%; canagliflozin 1.3%) dipeptidyl peptidase-4 inhibitors, matched 1:1 on basis a propensity...
The use of proton pump inhibitors (PPIs) in children has increased substantially recent years, concurrently with emerging concerns that these drugs may increase the risk asthma. Whether PPI broad pediatric population is associated asthma not known.To investigate association between and children.This nationwide cohort study collected registry data Sweden from January 1, 2007, to December 31, 2016. Children adolescents 17 years or younger were matched by age propensity score into 80 870 pairs...
Background and Aims: Clinical trials suggest that glucagon-like peptide-1 (GLP-1) receptor agonists may have beneficial effects on NAFLD, but the impact hard hepatic end points is unknown. We assessed association between use of GLP-1 risk serious liver events in routine clinical practice. Approach Results: Cohort study using data from nationwide registers Sweden, Denmark, Norway, 2007–2020, including 91,479 initiators 244,004 active comparator, dipeptidyl peptidase-4 inhibitors, without a...
A recent meta-analysis of randomized trials suggested that use angiotensin receptor blockers (ARBs) may be associated with a modestly increased risk incident cancer, particularly lung cancer.We linked individual-level data from Danish registries on filled drug prescriptions, diagnostic information, and covariates. In nationwide cohort new users ARBs angiotensin-converting enzyme inhibitors ≥35 years age during 1998 to 2006, we compared incidence rates all cancer subgroups by anatomic site,...
IMPORTANCE Metoclopramide, a drug frequently used for nausea and vomiting in pregnancy, is thought to be safe, but information on the risk of specific malformations fetal death lacking.OBJECTIVE To investigate safety metoclopramide use pregnancy.Register-based cohort study Denmark, 1997-2011.From 1 222 503 pregnancies, metoclopramide-exposed unexposed women were matched (1:4 ratio) basis age, calendar year, propensity scores. DESIGN, SETTING, AND PARTICIPANTSMAIN OUTCOMES MEASURES Primary...
The quadrivalent human papillomavirus (HPV) vaccine is recommended for all girls and women 9 to 26 years of age. Some will have inadvertent exposure vaccination during early pregnancy, but few data exist regarding the safety HPV in this context.We assessed a cohort that included Denmark who had pregnancy ending between October 1, 2006, November 30, 2013. Using nationwide registers, we linked information on vaccination, adverse outcomes, potential confounders among cohort. Women prespecified...