A5010010466- SARS-CoV-2 and COVID-19 Research
- Microfluidic and Bio-sensing Technologies
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Microfluidic and Capillary Electrophoresis Applications
- Biosensors and Analytical Detection
- Respiratory viral infections research
- Pneumonia and Respiratory Infections
- Immunodeficiency and Autoimmune Disorders
- Vaccine Coverage and Hesitancy
- Electrowetting and Microfluidic Technologies
- Digital Holography and Microscopy
- Data-Driven Disease Surveillance
- Characterization and Applications of Magnetic Nanoparticles
- Influenza Virus Research Studies
- SARS-CoV-2 detection and testing
- COVID-19 and healthcare impacts
- Image Processing Techniques and Applications
- Telecommunications and Broadcasting Technologies
- Climate Change and Health Impacts
- Migration, Health and Trauma
- Virology and Viral Diseases
- Optimism, Hope, and Well-being
- Global Security and Public Health
- Cell Image Analysis Techniques
Austrian Agency for Health and Food Safety
2018-2025
Graz University of Technology
2019-2025
Vienna University of Economics and Business
2019-2025
St. Pölten University of Applied Sciences
2023-2025
Brandenburg University of Technology Cottbus-Senftenberg
2023
Siemens Healthcare (Germany)
2016-2021
Gesundheit Österreich
2020-2021
University of Freiburg
2020
Austrian Academy of Sciences
2019
Medical University of Vienna
2019
A key question concerning coronavirus disease 2019 (COVID-19) is how effective and long lasting immunity against this in individuals who were previously infected with severe acute respiratory syndrome 2 (SARS-CoV-2). We aimed to evaluate the risk of SARS-CoV-2 re-infections general population Austria.This a retrospective observational study using national infection data from Austrian epidemiological reporting system. As primary outcome, we aim compare odds COVID-19 survivors first wave...
Invasive meningococcal disease (IMD) is a major cause of bacterial meningitis and septicaemia although infection by some serogroups may be prevented through vaccination. We aimed to describe the epidemiology IMD in EU/EEA countries during 2004-2014 monitor serogroup- age-specific trends, compare country trends period C conjugate (MCC) vaccine introduction.We analysed surveillance data age, gender, serogroup, outcome. estimated percentage change annual notification rate (NR), using linear...
Weekly monitoring of European all-cause excess mortality, the EuroMOMO network, observed high mortality during influenza B/Yamagata dominated 2017/18 winter season, especially among elderly. We describe and influenza-attributable season in Europe.Based on weekly reporting from 24 countries or sub-national regions, representing 60% population excluding Russian Turkish parts Europe, we estimated age stratified morality using model. In addition, was FluMOMO algorithm, incorporating activity...
Rapid detection of viral contamination remains a pressing issue in various fields related to human health including clinical diagnostics, the monitoring food-borne pathogens, biological warfare agents as well clearance studies for biopharmaceutical products. The majority currently available assays virus are expensive, time-consuming, and labor-intensive. In present work we report creation novel micro total analysis system (µTAS) capable continuously with high sensitivity selectivity....
Abstract Complete blood count and differentiation of leukocytes (DIFF) belong to the most frequently performed laboratory diagnostic tests. Here, a flow cytometry‐based method for label‐free DIFF untouched by digital holographic microscopy on rich phase contrast peripheral leukocyte images, using highly controlled 2D hydrodynamic focusing conditions is reported. Principal component analysis morphological characteristics reconstructed images allows classification nine types, in addition...
Summary This is a report on the first identified cases of coronavirus disease 2019 (COVID-19) in Austria. The documented case was person who stayed Kühtai, Tyrol, from 24 to 26 January 2020, and had been infected by Chinese instructor Starnberg (Germany) between 20 22 January. counts as German since her diagnosis eventually made Munich 28 On 25 February, two imported Italy were diagnosed Innsbruck but again no secondary three infections Austrian inhabitants detected 27 February Vienna....
Abstract We aim to identify those measures that effectively control the spread of SARS-CoV-2 in Austrian schools. Using cluster tracing data we calibrate an agent-based epidemiological model and consider situations where B1.617.2 (delta) virus strain is dominant parts population are vaccinated quantify impact non-pharmaceutical interventions (NPIs) such as room ventilation, reduction class size, wearing masks during lessons, vaccinations, school entry testing by SARS-CoV2-antigen tests. In...
Background: Observational studies may over- or under-estimate SARS-CoV-2 vaccine effectiveness (VE) depending on whether healthier (i.e. healthy effect (HVE)) more ill individuals are preferentially vaccinated. To evaluate this issue, we compared non-COVID-19, all-cause, cancer and COVID-19 mortality in vaccinated versus unvaccinated individuals. Methods: This is a nationwide retrospective observational study the entire adult population Austria with previously documented infection follow-up...
Rapid and specific rare cell detection for point-of-care testing requires an integration of the sample preparation flow cytometry. To achieve such a challenging goal we have developed magnetic cytometry technique which applies magnetophoresis to perform enrichment, focusing, background elimination in single step. Time-of-flight measurements are performed with integrated sensors detect specifically cancer cells diameters whole blood.
Abstract Introduction Evidence is limited on the effectiveness of a fourth vaccine dose against coronavirus disease 2019 (COVID‐19) in populations with prior severe acute respiratory syndrome 2 (SARS‐CoV‐2) infections. We estimated risk COVID‐19 deaths and SARS‐CoV‐2 infections according to vaccination status previously infected individuals Austria. Methods This nationwide retrospective observational study. calculated age gender adjusted Cox proportional hazard ratios (HRs) (primary outcome)...
Since the end of November 2023, European Mortality Monitoring Network (EuroMOMO) has observed excess mortality in Europe. During weeks 48 2023–6 2024, preliminary results show a substantially increased rate 95.3 (95% CI: 91.7–98.9) all-cause deaths per 100,000 person-years for all ages. This is seen adults aged 45 years and older, coincides with widespread presence COVID-19, influenza respiratory syncytial virus (RSV) many countries during 2023/24 winter season.
Background Human beings possess the capacity to cognize their own mortality, which compels them process death awareness. The present study seeks validate Death Reflection Scale (DRS) among older individuals, measures growth-oriented cognitions and prosocial behavior following confrontation with Materials methods DRS was validated using a cross-sectional online survey of adults (50+). To assess configural, metric, scalar measurement equivalence across age groups adults, multi-group...
Microfabricated biochips are developed to continuously monitor cell population dynamics in a non-invasive manner. In the presented work we describe novel combination of contact-less dielectric microsensors and microfluidics promote biofilm formation for quantitative analysis. The chip consists polymeric fluidic (PDMS) system bonded glass wafer containing electrodes while temperature fluid flow controlled by external heating pumping stations. high-density interdigitated capacitors (microIDES)...
Background In February 2012 the ten-valent pneumococcal conjugate vaccine (PCV10) with a 2+1 doses schedule (3, 5, 12 or 14 months of age) without catch-up vaccination was introduced in Austria. We assessed direct and indirect effects on invasive disease (IPD) by population-based intervention study. Methods The study period divided into pre- (2009–2011) post-period (2013–2017, February), regarding as transition year. Outcomes were defined PCV10 ST-IPD, PCV10-related ST 6A 19A IPD non-PCV10...
Between June-September 2018, 20 hepatitis A cases were notified in six counties Sweden. Combined epidemiological and microbiological investigations identified imported frozen strawberries produced Poland as the source of outbreak. Sequence analysis confirmed outbreak strain IB with 100 % identity respective batch was withdrawn. Sharing sequence information internationally led to identification 14 additional Austria, linked from same producer.
As nanotechnology moves towards widespread commercialization, new technologies are needed to adequately address the potential health impact of nanoparticles (NPs). Assessing safety over 30 000 NPs through animal testing would not only be expensive, but it also raise a number ethical considerations. Furthermore, existing in vitrocell-based assays sufficient scope complexity cell–nanoparticle interactions including NP translocation, accumulation and co-transport e.g. allergens. In particular,...
Effective malaria treatment requires rapid and accurate diagnosis of infecting species actual parasitemia. Despite the recent success tests, analysis thick thin blood smears remains gold standard for routine in endemic areas. For non-endemic regions, sample preparation are an issue due to low microscopy expertise few cases imported malaria. Automation results could be beneficial quickly confirm suspected infections such conditions. Here, we present a label-free, high-throughput method early...
An under recognized cause of preventable mortality is healthcare-associated (nosocomial) infections such as biofilms found on implants and catheters. About 5% U.S. E.U. patients acquire nosocomial leading to prolonged hospitalization, increased patient suffering, rates. To date, no satisfactory solutions are available monitor biofilm formation near-native conditions. As a consequence, in the present work, we report development disposable microfluidic biochip capable continuously monitoring...
Over the past 50 years, flow cytometry has had a profound impact on preclinical and clinical applications requiring single cell function information for counting, sub-typing quantification of epitope expression. At same time, workflow complexity high costs such optical systems still limit to specialized laboratories. Here, we present quantitative magnetic cytometer that incorporates in situ magnetophoretic focusing highly accurate reproducible rolling cellular targets over giant...
Time-of-flight (TOF) magnetic sensing of rolling immunomagnetically-labeled cells offers great potential for single cell function analysis at the bedside in even optically opaque media, such as whole blood. However, due to spatial resolution sensor and low flow rate regime required observe behavior cells, concentration range a workflow is limited. Potential clinical applications, testing leukocyte function, require cytometer which can cover several orders magnitude. This challenging task an...
Abstract SARS-CoV-2 surveillance is crucial to identify variants with altered epidemiological properties. Wastewater-based epidemiology (WBE) provides an unbiased and complementary approach sequencing individual cases. Yet, national WBE programs have not been widely implemented data analyses remain challenging. We deep-sequenced 2,093 wastewater samples representing 95 municipal catchments, covering >57% of Austria’s population, from December 2020 September 2021. Our Va riant Qu...
Although liposomes have many outstanding features such as biocompatibility, biodegradability, low toxicity and structural diversity, are successfully applied in areas of chemistry biotechnology, a lack characterization standards quality control tools still inhibiting the translation liposome technology into clinical routine. The greatest obstacle to scale commercialization is inability ensure formulation stability because small size variations or altered surface chemistries can significantly...
Abstract We quantified serum concentrations of chemokine CXCL10 in 288 patients with measles virus (MeV) primary infection and 16 reinfection (vaccine failure). peaked emergence IgM antibodies was elevated hospitalized (3233 vs 1930 pg/mL, P < .0001). differed between (1958 932 = .0402). In comparison to other viral infections rash-like symptoms, highly MeV (area under the curve 0.935; 95% confidence interval, .905–.965; is a potential marker for diagnosis, stage, severity infection.