A5080652506- Cardiovascular Function and Risk Factors
- Cardiac Imaging and Diagnostics
- Influenza Virus Research Studies
- Cardiovascular Disease and Adiposity
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Health and Disease Prevention
- Heart Failure Treatment and Management
- Heart Rate Variability and Autonomic Control
- Diabetes Treatment and Management
- Vaccine Coverage and Hesitancy
- COVID-19 Clinical Research Studies
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory viral infections research
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Cardiac Valve Diseases and Treatments
- Long-Term Effects of COVID-19
- Cardiovascular Effects of Exercise
- Receptor Mechanisms and Signaling
- Respiratory Support and Mechanisms
- Cardiac Arrhythmias and Treatments
- Cardiac electrophysiology and arrhythmias
- Congenital Heart Disease Studies
- Mobile Health and mHealth Applications
- Cardiac Health and Mental Health
University of Copenhagen
1987-2025
Brigham and Women's Hospital
2024-2025
Gentofte Hospital
2020-2025
Copenhagen University Hospital
1987-2025
Harvard University
2024-2025
Herlev Hospital
2023-2024
Center for Clinical & Basic Research
2024
Odense University Hospital
2024
Frederiksberg Hospital
2000-2023
Bispebjerg Hospital
2022-2023
The present study had two aims: (i) compare echocardiographic parameters in COVID-19 patients with matched controls and (2) assess the prognostic value of measures left (LV) right ventricular (RV) function relation to related death.In this prospective multicentre cohort study, 214 consecutive hospitalized underwent an examination (by pre-determined research protocol). All participants were successfully 1:1 from general population on age, sex, hypertension. Mean age sample was 69 years, 55%...
Left atrial (LA) strain parameters have been demonstrated to be valuable predictors of fibrillation (AF) in several patient cohorts. The purpose this study was investigate whether LA strain, assessed by two-dimensional speckle-tracking echocardiography, can used predict the development AF general population.This prospective longitudinal included 4466 participants from fifth Copenhagen City Heart Study. All underwent a health examination, including echocardiographic measurements strain....
Left atrial (LA) function assessed by two-dimensional speckle-tracking echocardiography has shown increasing clinical and prognostic significance. We sought to establish age- sex-based normative values of LA strain in the general population assess yield lower limits normality relation future fibrillation (AF).We determined peak longitudinal (PALS), contraction (PACS), during conduit phase (LACS) 1641 healthy participants included fifth Copenhagen City Heart Study. In a secondary analysis,...
BACKGROUND: The relative vaccine effectiveness (rVE) of high-dose quadrivalent influenza vaccines (QIV-HD) versus standard-dose (QIV-SD) against hospitalizations and mortality in the general older population has not been evaluated an individually randomized trial. Because large sample size required, such a trial will need to incorporate innovative, pragmatic elements. METHODS: We conducted pragmatic, open-label, active-controlled, feasibility Danish citizens aged 65 79 years during 2021–2022...
Background: Pressure-strain loop analyses is a noninvasive technique capable of evaluating myocardial work. Reference values are needed to benchmark these work indices for clinical practice. Methods: Healthy participants from general population study were used establish reference global index (GWI), constructive (GCW), wasted (GWW), and efficiency (GWE) measured by pressure-strain analyses. The relation age sex was examined. We furthermore examined the proportion abnormal according low,...
3D echocardiographic (3DE) assessment of the left atrium (LA) is a new modality potential clinical value. Age- and sex-based normative values are needed to benchmark these parameters for use.
ObjectivesTo evaluate the relative effectiveness of high-dose quadrivalent influenza vaccine (QIV-HD) vs. standard-dose (QIV-SD) against recurrent hospitalisations and its potential variation in relation to circulation.MethodsWe did a post-hoc analysis pragmatic, open-label, randomised trial QIV-HD QIV-SD conducted during 2021-2022 season among adults aged 65-79 years. Participants were enrolled October-November, 2021 followed for outcomes from 14 days post-vaccination until May 31, 2022. We...
Yearly influenza vaccination is strongly recommended for older adults and patients with chronic diseases including cardiovascular disease (CVD); however, rates remain suboptimal, particularly among younger patients. Electronic letters incorporating behavioral nudges are highly scalable public health interventions which can potentially increase vaccination, but further research needed to determine the most effective strategies assess effectiveness across different populations. The purpose of...
As heart failure therapeutic care becomes increasingly complex, a composite medical therapy score could be useful to conveniently summarize background therapy. We applied the developed by Heart Failure Collaboratory (HFC) Danish with reduced ejection fraction population evaluate its external validation including assessing distribution of and association survival.
Annual influenza vaccination is widely recommended in older adults and other high-risk groups including patients with cardiovascular disease. The real-world effectiveness of limited by suboptimal uptake effective strategies for increasing rates are therefore needed. purpose this trial to investigate whether behavioral nudges digitally delivered via the Danish nationwide mandatory governmental electronic letter system can increase among adults.The NUDGE-FLU a randomized implementation...
Despite strong worldwide guideline recommendations, influenza vaccination rates remain suboptimal among young and middle-aged patients with chronic diseases. Effective scalable strategies to increase are needed.
Abstract Background Patient-reported outcomes (PRO) and self-swab studies may offer to improve monitoring of infectious diseases. The DANFLU-2 HomeSwab PRO study aimed assess the practicality self-administered swabs digital tracking monitor influenza-like illness (ILI). Methods As part a sub-study trial, participants were instructed self-report ILI quality life (QoL) using Respiratory Intensity Impact Questionnaire (RiiQ) for 14 days following symptom onset. If symptomatic, home-based was...
ABSTRACT Background Influenza infection has been associated with multiple cardiac complications including acute heart failure and myocardial infarction. The FluHeart study aims to uncover the potential effect of influenza on structure function as assessed by echocardiography during hospitalization. Methods This prospective cohort included hospitalized patients 2021–2022 season. Participants underwent using a prespecified protocol. were successfully matched 1:1:1 age, sex, status controls...
This secondary analysis of a randomized clinical trial investigates whether electronic nudging letters to increase influenza vaccination have an effect on COVID-19 vaccination, infection, and hospitalization.
Background: Vitamin K is a cofactor necessary for the biological activity of proteins like Matrix Gla Protein (MGP), which reduce calcification and help preserve lung function. This study aims to determine, first, whether low vitamin status associated with chronic obstructive pulmonary disease (COPD), secondary, level COPD severity, smoking exposure, or mortality. Methods: The plasma concentration dephosphorylated uncarboxylated (dp-uc) MGP was used as an inverse biomarker in 98 patients...
Treatment guidelines for chronic kidney disease (CKD) recommend sodium-glucose cotransporter 2 inhibitors (SGLT2i) as first-line treatment a broad range of individuals with CKD, alongside renin-angiotensin system (RASi). However, adoption in clinical practice is often delayed, potentially leading to avoidable associated morbidity and mortality. Effective strategies are needed improve implementation guideline-directed medical therapy (GDMT) patients CKD. This trial will evaluate the...
The development and pharmacology of a new potent growth hormone (GH) secretagogue, ipamorelin, is described. Ipamorelin pentapeptide (Aib-His-D-2-Nal-D-Phe-Lys-NH2), which displays high GH releasing potency efficacy in vitro vivo. As an outcome major chemistry programme, ipamorelin was identified within series compounds lacking the central dipeptide Ala-Trp hormone-releasing peptide (GHRP)-1. In vitro, released from primary rat pituitary cells with similar to GHRP-6 (ECs) = 1.3+/-0.4nmol/l...