A5048775979- Vector-borne infectious diseases
- Viral Infections and Vectors
- Vector-Borne Animal Diseases
- Insect and Pesticide Research
- Insect symbiosis and bacterial influences
- Zoonotic diseases and public health
- Yersinia bacterium, plague, ectoparasites research
- Mosquito-borne diseases and control
- Toxin Mechanisms and Immunotoxins
- SARS-CoV-2 and COVID-19 Research
- Dermatological diseases and infestations
- SARS-CoV-2 detection and testing
- COVID-19 Clinical Research Studies
- Immunodeficiency and Autoimmune Disorders
- Liver Disease Diagnosis and Treatment
- Autoimmune Bullous Skin Diseases
- Rabies epidemiology and control
- Muscle Physiology and Disorders
- Urticaria and Related Conditions
- Neurogenetic and Muscular Disorders Research
- Genital Health and Disease
- COVID-19 epidemiological studies
- Oral Health Pathology and Treatment
- Complement system in diseases
- Lymphatic System and Diseases
Ludwig-Maximilians-Universität München
2002-2025
Institute of Bioinformatics and Systems Biology
2014-2024
Bayerisches Landesamt für Gesundheit und Lebensmittelsicherheit
2015-2024
Instand
2024
Health and Safety Authority
2009-2023
European Society of Clinical Microbiology and Infectious Diseases
2016-2022
German Center for Infection Research
2021
Amsterdam UMC Location University of Amsterdam
2019
University Medical Center
2019
University of Amsterdam
2019
Lyme neuroborreliosis (LNB) is a nervous system infection caused by Borrelia burgdorferi sensu lato (Bb).To present evidence-based recommendations for diagnosis and treatment.Data were analysed according to levels of evidence as suggested EFNS.The following three criteria should be fulfilled definite LNB, two them possible LNB: (i) neurological symptoms; (ii) cerebrospinal fluid (CSF) pleocytosis; (iii) Bb-specific antibodies produced intrathecally. PCR CSF culture may corroborative if...
In December, 2019, the newly identified severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, China, causing COVID-19, a disease presenting with fever, cough, and often pneumonia. WHO has set strategic objective to interrupt spread of SARS-CoV-2 worldwide. An outbreak Bavaria, Germany, starting at end January, 2020, provided opportunity study transmission events, incubation period, secondary attack rates.
ABSTRACT Analysis of Lyme borreliosis (LB) spirochetes, using a novel multilocus sequence analysis scheme, revealed that OspA serotype 4 strains (a rodent-associated ecotype) Borrelia garinii were sufficiently genetically distinct from bird-associated B. to deserve species status. We suggest be raised status and named bavariensis sp. nov. The rooted phylogenetic trees provide insights into the evolutionary history LB spirochetes.
The need for timely establishment of diagnostic assays arose when Germany was confronted with the first travel-associated outbreak severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in Europe. We describe our laboratory experiences during a large contact tracing investigation, comparing previously published real-time RT-PCR different PCR systems and commercial kit. found that assay performance using same primers probes varied kit performed well.
We describe the isolation and characterization of Rickettsia monacensis sp. nov. (type strain, IrR/Munich(T)) from an Ixodes ricinus tick collected in a city park, English Garden Munich, Germany. Rickettsiae were propagated vitro with scapularis cell line ISE6. BLAST analysis 16S rRNA, citrate synthase, partial 190-kDa rickettsial outer membrane protein A (rOmpA) gene sequences demonstrated that isolate was spotted fever group (SFG) rickettsia closely related to several yet-to-be-cultivated...
Human granulocytotropic ehrlichias are tick-borne bacterial pathogens that cause an acute, life-threatening illness, human granulocytic ehrlichiosis (HGE). Ehrlichias within neutrophil granulocytes invade tick bite sites likely ingested by the vector, to be transmitted another mammalian host during tick's next blood meal. Thus, cycle of replication and development in vector is prerequisite infection, yet these events have not been described. We report cell culture isolation two strains HGE...
Anaplasma phagocytophilum is a gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals. In contrast to the United States, human granulocytic anaplasmosis seems be rare disease Europe despite initial recognition of A. as causative agent tick-borne fever European sheep cattle. Considerable strain variation has been suggested occur within this species, because isolates from animals differed their pathogenicity for...
The genus Borrelia, originally described by Swellengrebel in 1907, contains tick- or louse-transmitted spirochetes belonging to the relapsing fever (RF) group of spirochetes, Lyme borreliosis (LB) and that form intermittent clades. In 2014 it was proposed Borrelia should be separated into two genera; 1907 emend. Adeolu Gupta containing RF Borreliella LB spirochetes. this study we conducted an analysis based on a method is suitable for bacterial demarcation, percentage conserved proteins...
Since the original description of Borrelia bavariensis sp. nov. in 2009, additional samples available from humans and ticks Europe Mongolia, respectively, have been used to further characterize strains belonging this group spirochaetes that utilize rodents as reservoir hosts. These investigations suggested presence related Asia confirmed their status representing a distinct species. Furthermore, were investigated by researchers China Japan confirm ecological relationship members proposed...
To assess Borrelia burgdorferi sensu lato (the cause of Lyme borreliosis) seropositivity in Germany, we tested serum samples from health survey (2008-2011) participants. Seroprevalence was 5.8% among women and 13.0% men; infection risk highest persons >60 years age. Public interventions, including education about factors preventive measures, are needed.
Abstract Borrelia miyamotoi is a newly recognized human pathogen in the relapsing fever group of spirochetes. We investigated case B. infection central nervous system resembling burgdorferi–induced Lyme neuroborreliosis and determined that this emergent agent can be diagnosed with existing methods.
Lyme borreliosis (LB) is the most commonly reported tick-borne disease in Germany. In 9/16 states, notification of erythema migrans (EM), acute neuroborreliosis (NB) and arthritis (LA) mandatory. We describe incidence measures, time trends, geographical distribution frequencies manifestations to better understand LB epidemiology target prevention measures. used cases notified 9 states confirmed by local health offices, 2013-2017, calculate incidences time, place person. Altogether, we...
Quantitative serological assays detecting response to SARS-CoV-2 are needed quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 in oligo-/asymptomatic individuals from a population-based cohort.In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction [RT-PCR]-positive pharyngeal swabs, 111 negative controls, 143 positive serology without confirmation by RT-PCR) were tested (Euroimmun Anti-SARS-CoV-2 QuantiVac...