A5048104176- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- SARS-CoV-2 and COVID-19 Research
- Mercury impact and mitigation studies
- COVID-19 Clinical Research Studies
- Pesticide Exposure and Toxicity
- Heavy Metal Exposure and Toxicity
- SARS-CoV-2 detection and testing
- Pesticide Residue Analysis and Safety
- COVID-19 epidemiological studies
- Carcinogens and Genotoxicity Assessment
- Environmental Toxicology and Ecotoxicology
- Delphi Technique in Research
- Long-Term Effects of COVID-19
- Nutritional Studies and Diet
- Chemical Analysis and Environmental Impact
- Child Nutrition and Water Access
- Pesticide and Herbicide Environmental Studies
- Per- and polyfluoroalkyl substances research
- Environmental Justice and Health Disparities
- Conservation Techniques and Studies
- Insect and Pesticide Research
- Building materials and conservation
Institute of Environmental Assessment and Water Research
2015-2025
Helmholtz Zentrum München
2019-2023
Ludwig-Maximilians-Universität München
2018-2023
Consejo Superior de Investigaciones Científicas
2010-2023
Institute of Bioinformatics and Systems Biology
2020-2021
Center for Environmental Health
2020
LMU Klinikum
2018-2019
Universitat de Barcelona
2017-2018
Institute of Advanced Chemistry of Catalonia
2015
Hospital de Sant Pau
1992
Quantitative serological assays detecting response to SARS-CoV-2 are needed quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 in oligo-/asymptomatic individuals from a population-based cohort.In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction [RT-PCR]-positive pharyngeal swabs, 111 negative controls, 143 positive serology without confirmation by RT-PCR) were tested (Euroimmun Anti-SARS-CoV-2 QuantiVac...
Given the large number of mild or asymptomatic SARS-CoV-2 cases, only population-based studies can provide reliable estimates magnitude pandemic. We therefore aimed to assess sero-prevalence in Munich general population after first wave For this purpose, we drew a representative sample 2994 private households and invited household members 14 years older complete questionnaires blood samples. seropositivity was defined as Roche N pan-Ig ≥ 0.4218. adjusted prevalence for sampling design,...
Phthalates are a group of widely used chemicals and humans exposed to them in their daily life. Some phthalates may affect the hormonal balance both children adults. The aim this study was assess phthalate exposure its determinants among at age 7 years from Polish Mother Child Cohort Study (REPRO_PL). 250 urine samples collected 2014-2015 were analysed for 21 metabolites 11 parent using on-line high performance liquid chromatography coupled tandem mass spectrometry (HPLC-MS/MS). This...
An accurate and sensitive method for the determination of a total 23 pesticides their metabolites in human urine has been optimised. The methodology is based on previously published solid-phase extraction with methanol acetone followed by ultra-performance liquid chromatography coupled to tandem mass spectrometry (UPLC-MS/MS) selected reaction mode (SRM) both positive negative electrospray ionization (ESI+/-). detection settings previous method, which allowed determine from 6 organophosphate...
Prenatal exposure to organophosphate flame retardants (OPFRs) may pose potential health risks offspring. While prior studies have demonstrated that OPFRs can be transferred from mothers fetuses, the mechanism underlying transplacental transfer remains unclear. The pregnant ICR mouse and JAR cell (a monolayer model), in combination with molecular docking, were used explore mechanism. rapidly metabolized into diester metabolites following oral gavage mouse, considerable concentrations detected...
Summary We studied the effect of purified immunoglobulins (Ig) from 21 patients with antiphospholipid antibodies (aPL) on factor Va degradation by activated protein C (aPC) cultured human umbilical vein endothelial cells (HUVEC). Sera were tested an ELISA aPL assay to determine isotype activity. HUVEC incubated IgG or IgM fraction controls patients. Activated PC and then added was measured after several reaction times. 13 14 8 10 showed inhibitory aPC when compared control Ig. also observed...
Background Adaptive immune responses to structural proteins of the virion play a crucial role in protection against coronavirus disease 2019 (COVID-19). We therefore studied T cell multiple SARS-CoV-2 large cohort using simple, fast, and high-throughput approach. Methods An automated interferon gamma release assay (IGRA) for Nucleocapsid (NC)-, Membrane (M)-, Spike-C-terminus (SCT)-, N-terminus-protein (SNT)-specific was performed fresh whole blood from study subjects with convalescent,...
A number of seroassays are available for SARS-CoV-2 testing; yet, head-to-head evaluations different testing principles limited, especially using raw values rather than categorical data. In addition, identifying correlates protection is utmost importance, and comparisons systems with functional assays, such as direct viral neutralisation, needed.We analysed 6658 samples consisting true-positives ( n =193), true-negatives =1091), specimens unknown status =5374). For primary testing, we used...
Abstract Background In the 2nd year of COVID-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November...
Organophosphate (OP) and pyrethroid pesticides (PYR) are extensively used in agriculture, resulting higher exposures among farmworkers. The present study reports the occurrence of 8 urinary OP PYR metabolites a sample farmworkers residents from Sucs (n = 87), rural township North West Catalonia (Spain). aim was to examine differences pesticide metabolite concentrations between occupationally-exposed (farmworkers; n 45) environmentally-exposed subjects 42) assess relationship pesticide's...
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding acute long-term virological immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May December 2020 in Munich, Germany, followed up at multiple defined timepoints to one year. viral culture performed seroresponses measured. Participants classified applying the WHO clinical scale. Short symptom test time (median 5.0 days; p = 0.0016) high loads (VL;...