Leonard Gilberg
A5013882341- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- SARS-CoV-2 detection and testing
- Medical Imaging and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Autoimmune and Inflammatory Disorders Research
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Radiology practices and education
- Dental Radiography and Imaging
- Artificial Intelligence in Healthcare and Education
- Traumatic Brain Injury and Neurovascular Disturbances
- Biomarkers in Disease Mechanisms
- Biosensors and Analytical Detection
- Long-Term Effects of COVID-19
- Management of metastatic bone disease
- Animal Virus Infections Studies
- vaccines and immunoinformatics approaches
- Bone health and osteoporosis research
- Intracranial Aneurysms: Treatment and Complications
- Cerebrovascular and Carotid Artery Diseases
- COVID-19 epidemiological studies
- Advanced X-ray and CT Imaging
Ludwig-Maximilians-Universität München
2021-2024
LMU Klinikum
2021-2024
Abstract Background Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate development, repair, pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PCS), increasingly recognized in convalescent individuals. ILCs have been associated with the severity symptoms but their role development PCS remains poorly defined. Methods results Here, we used multiparametric phenotyping, finding expanded...
Background Adaptive immune responses to structural proteins of the virion play a crucial role in protection against coronavirus disease 2019 (COVID-19). We therefore studied T cell multiple SARS-CoV-2 large cohort using simple, fast, and high-throughput approach. Methods An automated interferon gamma release assay (IGRA) for Nucleocapsid (NC)-, Membrane (M)-, Spike-C-terminus (SCT)-, N-terminus-protein (SNT)-specific was performed fresh whole blood from study subjects with convalescent,...
A number of seroassays are available for SARS-CoV-2 testing; yet, head-to-head evaluations different testing principles limited, especially using raw values rather than categorical data. In addition, identifying correlates protection is utmost importance, and comparisons systems with functional assays, such as direct viral neutralisation, needed.We analysed 6658 samples consisting true-positives ( n =193), true-negatives =1091), specimens unknown status =5374). For primary testing, we used...
Abstract Background In the 2nd year of COVID-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November...
Incidental spinal bone lesions, potential indicators of malignancies, are frequently underreported in abdominal and thoracic CT imaging due to scan focus diagnostic bias towards patient complaints. Here, we evaluate a deep-learning algorithm (DLA) designed support radiologists’ reporting incidental lesions during routine clinical practice. The present study is structured into two phases: unaided AI-assisted. A total 32 scans from multiple radiology centers were selected randomly...
Measuring specific anti-SARS-CoV-2 antibodies has become one of the main epidemiological tools to survey ongoing SARS-CoV-2 pandemic, but also vaccination response. The WHO made available a set well-characterized samples derived from recovered individuals allow normalization between different quantitative anti-Spike assays defined Binding Antibody Units (BAU).To assess sero-responses longitudinally, cohort ninety-nine RT-PCR positive subjects was followed up together with forty-five...
Population-based serological studies allow to estimate prevalence of SARS-CoV-2 infections despite a substantial number mild or asymptomatic disease courses. This became even more relevant for decision making after vaccination started. The KoCo19 cohort tracks the pandemic progress in Munich general population over two years, setting it apart Europe.Recruitment occurred during initial wave, including 5313 participants above 13 years from private households Munich. Four follow-ups were held...
Abstract Background Serosurveys are essential to understand SARS-CoV-2 exposure and enable population-level surveillance, but currently available tests need further in-depth evaluation. We aimed identify testing-strategies by comparing seven seroassays in a population-based cohort. Methods analysed 6,658 samples consisting of true-positives (n=193), true-negatives (n=1,091), specimens unknown status (n=5,374). For primary testing, we used Euroimmun-Anti-SARS-CoV-2-ELISA-IgA/IgG...
Abstract Innate lymphoid cells (ILCs) are key organizers of tissue immune responses and regulate development, repair, pathology. Persistent clinical sequelae beyond 12 weeks following acute COVID-19 disease, named post-COVID syndrome (PCS), increasingly recognized in convalescent individuals. ILCs have been associated with the severity symptoms but their role development PCS remains poorly defined. Here we used multiparametric phenotyping, finding expanded circulating ILC precursors (ILCPs)...
(1) Background: Unruptured Intracranial Aneurysms (UIAs) are common blood vessel malformations, occurring in up to 3 % of healthy adults. Magnetic Resonance Angiography (MRA) is frequently used for the screening UIAs due its high resolution vascular anatomy. However, T2-Weighted Imaging (T2WI) a standard sequence utilized majority outpatient head scans. By employing such as T2WI, there possible shift towards early detection through opportunistic screening. Here, we assess Deep Learning...