Abhishek Bakuli
A5036001420- Lymphoma Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- CAR-T cell therapy research
- COVID-19 Clinical Research Studies
- COVID-19 epidemiological studies
- Chronic Lymphocytic Leukemia Research
- SARS-CoV-2 detection and testing
- Tuberculosis Research and Epidemiology
- Monoclonal and Polyclonal Antibodies Research
- Pneumonia and Respiratory Infections
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Health, Environment, Cognitive Aging
- Respiratory viral infections research
- Acute Lymphoblastic Leukemia research
- Pneumocystis jirovecii pneumonia detection and treatment
- Mycobacterium research and diagnosis
- COVID-19 and Mental Health
- COVID-19 Pandemic Impacts
- Asthma and respiratory diseases
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Pediatric health and respiratory diseases
- Long-Term Effects of COVID-19
- Health disparities and outcomes
- Viral Infections and Outbreaks Research
- S100 Proteins and Annexins
Ludwig-Maximilians-Universität München
2019-2024
German Center for Infection Research
2021-2023
LMU Klinikum
2020-2023
MorphoSys (Germany)
2022-2023
Helmholtz Centre for Infection Research
2017-2018
Medizinische Hochschule Hannover
2018
Novartis (India)
2014
Humanitarian crises and migration make girls women more vulnerable to poor sexual reproductive health (SRH) outcomes. Nevertheless, there is still a dearth of information on SRH outcomes access services among refugee young in Africa. We conducted mixed-methods study assess experiences, knowledge the Nakivale settlement, Uganda. A cross-sectional survey 260 adolescent 13–19 years old was between March May 2018. Concurrently, in-depth interviews were subset 28 adolescents. For both methods,...
Quantitative serological assays detecting response to SARS-CoV-2 are needed quantify immunity. This study analyzed the performance and correlation of two quantitative anti-S1 in oligo-/asymptomatic individuals from a population-based cohort.In total, 362 plasma samples (108 with reverse transcription-polymerase chain reaction [RT-PCR]-positive pharyngeal swabs, 111 negative controls, 143 positive serology without confirmation by RT-PCR) were tested (Euroimmun Anti-SARS-CoV-2 QuantiVac...
Given the large number of mild or asymptomatic SARS-CoV-2 cases, only population-based studies can provide reliable estimates magnitude pandemic. We therefore aimed to assess sero-prevalence in Munich general population after first wave For this purpose, we drew a representative sample 2994 private households and invited household members 14 years older complete questionnaires blood samples. seropositivity was defined as Roche N pan-Ig ≥ 0.4218. adjusted prevalence for sampling design,...
Abstract Background Due to the SARS-CoV-2 pandemic, public health interventions have been introduced globally in order prevent spread of virus and avoid overload care systems, especially for most severely affected patients. Scientific studies date focused primarily on describing clinical course patients, identifying treatment options developing vaccines. In Germany, as many other regions, current tests SARS-CoV2 are not conducted a representative basis longitudinal design. Furthermore,...
BackgroundOver 1 year since the first reported case, true COVID-19 burden in Ethiopia remains unknown due to insufficient surveillance. We aimed investigate seroepidemiology of SARS-CoV-2 among front-line hospital workers and communities Ethiopia.MethodsWe did a population-based, longitudinal cohort study at two tertiary teaching hospitals involving workers, rural residents, urban Jimma Addis Ababa. Hospital were recruited both hospitals, community participants by convenience sampling...
Tafasitamab, an anti-CD19 immunotherapy, is used with lenalidomide for patients autologous stem cell transplant-ineligible relapsed/refractory diffuse large B-cell lymphoma based on the results of phase II L-MIND study (NCT02399085). We report final 5-year analysis this study. Eighty ≥18 years who had received one to three prior systemic therapies, and Eastern Cooperative Oncology Group performance status 0-2 up 12 cycles co-administered tafasitamab lenalidomide, followed by monotherapy...
Tuberculosis remains a global health concern, and half of cured patients have permanent lung injury. N-acetylcysteine (NAC) has shown beneficial antimicrobial, antioxidant, immunomodulatory effects in preclinical tuberculosis models. We examined its on treatment outcomes.
A number of seroassays are available for SARS-CoV-2 testing; yet, head-to-head evaluations different testing principles limited, especially using raw values rather than categorical data. In addition, identifying correlates protection is utmost importance, and comparisons systems with functional assays, such as direct viral neutralisation, needed.We analysed 6658 samples consisting true-positives ( n =193), true-negatives =1091), specimens unknown status =5374). For primary testing, we used...
Abstract Background In the 2nd year of COVID-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November...
Since 2020 SARS-CoV-2 spreads pandemically, infecting more than 119 million people, causing >2·6 fatalities. Symptoms of infection vary greatly, ranging from asymptomatic to fatal. Different populations react differently the disease, making it very hard track spread in a population. Measuring specific anti-SARS-CoV-2 antibodies is an important tool assess or successful vaccinations. To achieve sufficient sample numbers, alternatives venous blood sampling are needed not requiring medical...
Abstract Background Despite microbiological cure, about 50% of tuberculosis (TB) patients have poor lung recovery. Neutrophils are associated with pathology; however, CD16/CD62L-defined subsets not been studied in TB. Using flow cytometry, we monitored frequencies, phenotype, and function neutrophils following stimulation Mycobacterium (Mtb) whole cell lysate (WCL) ESAT-6/CFP-10 fusion protein (EC) relation to pathology. Methods Fresh blood from 42 adult, human immunodeficiency virus...
Risk factors for disease progression and severity of SARS-CoV-2 infections require an understanding acute long-term virological immunological dynamics. Fifty-one RT-PCR positive COVID-19 outpatients were recruited between May December 2020 in Munich, Germany, followed up at multiple defined timepoints to one year. viral culture performed seroresponses measured. Participants classified applying the WHO clinical scale. Short symptom test time (median 5.0 days; p = 0.0016) high loads (VL;...
Abstract Background Pulmonary tuberculosis (PTB) is frequently associated with chronic respiratory impairment despite microbiological cure. There are only a few clinical research studies that describe the course, type and severity as well risk factors for lung (LI) in TB patients. Methods A prospective cohort study was conducted at Research Clinic of Instituto Nacional de Saúde Mavalane, Maputo, from June 2014 to 2016. PTB patients were prospectively enrolled followed 52 weeks after...
Background Quantitative serological assays detecting response to SARS-CoV-2 infection are urgently needed quantify immunity. This study analyzed the performance and correlation of two independent quantitative anti-S1 in oligo-/asymptomatic individuals from a previously characterized population-based cohort. Methods A total 362 samples included 108 who had viral RNA detected pharyngeal swabs, 111 negative controls 143 with positive serology but not confirmed by RT-PCR. Blood plasma was tested...
Background The inflammatory response to Mycobacterium tuberculosis results in variable degrees of lung pathology during active TB (ATB) with central involvement neutrophils. Little is known about neutrophil-derived mediators and their role disease severity at baseline recovery upon treatment initiation. Methods 107 adults confirmed pulmonary were categorised based on following successful therapy using chest X-ray scores (Ralph scores) GeneXpert bacterial load (Ct values). Plasma, sputum,...
Abstract Background The highly complex and largely neglected Chagas disease (CD) has become a global health problem due to population movements between Latin America non-endemic countries, as well non-vectorial transmission routes. Data on CD testing treatment from routine patient care in Germany of almost two decades was collected analysed. Methods German laboratories offering diagnostics for chronic Trypanosoma cruzi ( T. ) infection were identified. All retrievable data tests performed...
Abstract Bacterial killing in patients with tuberculosis (TB) relapse was compared to that achieving cure, measured by TB molecular bacterial load assay (TB-MBLA) or mycobacteria growth indicator tube (MGIT) time positivity (TTP). TB-MBLA 4 relapsed significantly different 132 cured after 2 weeks of treatment; MGIT TTP showed a significant difference from week 8.
Abstract Background In the 2 nd year of Covid-19 pandemic, knowledge about dynamics infection in general population is still limited. Such information essential for health planners, as many those infected show no or only mild symptoms and thus, escape surveillance system. We therefore aimed to describe course pandemic Munich living private households from April 2020 January 2021. Methods The KoCo19 baseline study took place June including 5313 participants (age 14 years above). From November...
Abstract Objectives Although a growing share of the population in many countries has been vaccinated against SARS-CoV-2 virus to different degrees, social distancing and hygienic non-pharmaceutical interventions still play substantial role containing pandemic. The goal this study was investigate which factors are correlated with higher compliance these regulations context cohort city Munich, southern Germany, during summer 2020, i.e. after first lockdown phase. Methods Using self-reported...
Measuring specific anti-SARS-CoV-2 antibodies has become one of the main epidemiological tools to survey ongoing SARS-CoV-2 pandemic, but also vaccination response. The WHO made available a set well-characterized samples derived from recovered individuals allow normalization between different quantitative anti-Spike assays defined Binding Antibody Units (BAU).To assess sero-responses longitudinally, cohort ninety-nine RT-PCR positive subjects was followed up together with forty-five...
Population-based serological studies allow to estimate prevalence of SARS-CoV-2 infections despite a substantial number mild or asymptomatic disease courses. This became even more relevant for decision making after vaccination started. The KoCo19 cohort tracks the pandemic progress in Munich general population over two years, setting it apart Europe.Recruitment occurred during initial wave, including 5313 participants above 13 years from private households Munich. Four follow-ups were held...
Abstract Background We assessed the impact of point-of-care (PoC) test-and-treat at birth on clinical outcomes and viral suppression among human immunodeficiency virus (HIV)–positive infants in Mozambique Tanzania. Methods This cluster-randomized trial allocated health facilities to intervention, providing PoC testing antiretroviral treatment (ART) week 4–8, or control, starting these 4–8. The primary outcome was proportions events (mortality, morbidity, retention, virological failure,...
Abstract Background Serosurveys are essential to understand SARS-CoV-2 exposure and enable population-level surveillance, but currently available tests need further in-depth evaluation. We aimed identify testing-strategies by comparing seven seroassays in a population-based cohort. Methods analysed 6,658 samples consisting of true-positives (n=193), true-negatives (n=1,091), specimens unknown status (n=5,374). For primary testing, we used Euroimmun-Anti-SARS-CoV-2-ELISA-IgA/IgG...
Acute respiratory infections (ARI) and acute gastrointestinal (AGI) are the most common childhood infections, corresponding data can either be collected prospectively or retrospectively. The aim of this study was to estimate incidence episodes in German households with children attending day care compare results prospective retrospective collection. We conducted a 4 months cohort winter period 2014/2015 recruited parents aged 0–6 years 75 centers Braunschweig, Lower Saxony, Germany. For all...
Transmission of acute respiratory infections (ARI) and gastroenteritis (AGE) often occurs in households. The aim this study was to assess which proportion ARI AGE is introduced transmitted by children German households with attending child care. We recruited families aged 0-6 years Braunschweig (Germany), for a 4 months prospective cohort the winter period 2014/2015. Every household member included health diary used nasal swabs pathogen identification case ARI. defined transmission if two...