A5075128410- HIV/AIDS Research and Interventions
- COVID-19 and Mental Health
- Adolescent Sexual and Reproductive Health
- Global Maternal and Child Health
- COVID-19 epidemiological studies
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Infection Control and Ventilation
- Mobile Health and mHealth Applications
- HIV, Drug Use, Sexual Risk
- Digital Mental Health Interventions
- COVID-19 Impact on Reproduction
- Migration, Health and Trauma
- Respiratory viral infections research
- HIV/AIDS Impact and Responses
- Psychological Well-being and Life Satisfaction
- Parasites and Host Interactions
- Malaria Research and Control
- Travel-related health issues
- Sports and Physical Education Research
- Sex and Gender in Healthcare
- Child Development and Education
Charité - Universitätsmedizin Berlin
2015-2025
Humboldt-Universität zu Berlin
2020-2025
Freie Universität Berlin
2020-2025
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2020-2024
Since 2008, Tanzanian guidelines for prevention of mother-to-child-transmission HIV (PMTCT) recommend combination regimen mother and infant starting in gestational week 28. Combination prophylaxis is assumed to be more effective less prone resistance formation compared single-drug interventions, but the required continuous collection intake drugs might pose a challenge on adherence especially peripheral resource-limited settings. This study aimed at analyzing under field conditions rural...
Intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine–pyrimethamine (SP) is widely implemented sub-Saharan Africa for the prevention of malaria and adverse birth outcomes. However, areas intense SP resistance, efficacy IPTp may be compromised. A cross-sectional study among 915 delivering women (728 analysable live singleton deliveries) was conducted Fort Portal, western Uganda, to assess associations reported use, Plasmodium falciparum infection, maternal anaemia, low...
Since 2012, lifelong antiretroviral therapy for all HIV-positive pregnant women (“Option B+”) is recommended by WHO the prevention of mother-to-child transmission HIV (PMTCT). Many sub-Saharan African countries have since introduced this regimen, but to date, longer-term outcome evaluations are scarce. We conducted an observational study in Fort Portal Municipality, Uganda, describe uptake and adherence Option B+ during pregnancy. approaching antenatal care (ANC) services two hospitals were...
BackgroundSchool attendance during the COVID-19 pandemic is intensely debated.AimIn November 2020, we assessed SARS-CoV-2 infections and seroreactivity in 24 randomly selected school classes connected households Berlin, Germany.MethodsWe collected oro-nasopharyngeal swabs blood samples, examining infection IgG antibodies by RT-PCR ELISA. Household members self-swabbed. We individual institutional prevention measures. Classes with were retested after 1 week.ResultsWe examined 1,119...
During the COVID-19 pandemic, children and adolescents worldwide have disproportionally been affected in their psychological health wellbeing. We conducted a cohort study among German school children, aiming at assessing levels of general anxiety disorder (GAD) identifying associated factors second pandemic year.A 660 students from 24 Berlin schools was recruited to fill questionnaires including GAD-7 tool on symptoms three time points between June September 2021. To adjust for non-random...
Introduction Long-term health consequences after mild COVID-19 are not well described. Our aim was to estimate their prevalence and describe the time course of signs symptoms for a period up 24 months SARS-CoV-2 infection. Methods We conducted cohort study matched age, sex, test week among individuals who had attended public center at Charité—Universitätsmedizin Berlin, Germany. In early 2022, 576 former patients (>95% non-hospitalized) 302 uninfected responded questionnaire on...
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Introduction During the coronavirus disease-19 (COVID-19) lockdowns, children repeatedly experienced social isolation. Dealing with resulting post-pandemic health implications remains a challenge. The role of group recreational activities is crucial in promoting children’s health; however implementation can encounter challenges, especially when infections such as COVID-19 are surging. Objectives In this prospective observational study, we aimed to investigate whether safe cohorts be created...
The benefits of male partner involvement in antenatal care (ANC) and prevention mother-to-child transmission HIV (PMTCT) for maternal infant health outcomes have been well recognised. However, many sub-Saharan African settings, these services remains low. Previous research has suggested written invitation letters as a way to promote involvement. In this implementation study conducted at three sites southwest Tanzania, acceptability partners was assessed. Pre-study CVCT rates 2–19 % had...
Briefly before the first peak of COVID-19 pandemic in Berlin, Germany, schools closed mid-March 2020. Following re-opening, resumed operation at a reduced level for nine weeks. During this phase, we aimed assessing, among students and teachers, infection status, symptoms, individual behaviour, institutional prevention measures. Twenty-four primary secondary school classes, randomly selected across were examined. Oro-nasopharyngeal swabs capillary blood samples collected to determine...
Since 2012, the WHO recommends Option B+ for prevention of mother-to-child transmission HIV. This approach entails initiation lifelong antiretroviral therapy in all HIV-positive pregnant women, also implying protection during breastfeeding 12 months or longer. Research on long-term adherence to throughout is scarce date. Therefore, we conducted a prospective observational cohort study Fort Portal, Western Uganda, assess until 18 postpartum. In 2013, recruited 67 HIV-positive, enrolled women...
The COVID-19 pandemic and related restrictions have affected the wellbeing of schoolchildren worldwide, but extent duration specific problems are still not completely understood. We aimed to describe students’ psychosocial behavioral parameters associated factors during in Berlin, Germany. Our longitudinal study included 384 students from 24 randomly selected Berlin primary secondary schools, assessing at four time points between June 2020 March 2021. analyzed temporal changes proportions...
Abstract Partner involvement is considered to increase the effectiveness of female-oriented services for sexual and reproductive health (SRH), like those antenatal care (ANC) or prevention mother-to-child transmission HIV (PMTCT). However, male participation rates remain mostly low, previous research has identified restrictive provider attitudes among barriers partner in such services. Individual perspectives experiences healthcare providers are assumed significantly influence quality...
In many Sub-Saharan African settings male partner involvement in antenatal care (ANC) remains low, although great benefits for maternal and infant health outcomes have been long recognised, particular regarding the prevention of HIV transmission. Yet there is paucity on evidence effectiveness strategies to increase involvement. This controlled intervention trial Ruanda Health Centre Mbeya, Tanzania, assessed invitation letters ANC. Pregnant women approaching ANC without partners received...
While most Sub-Saharan African countries are now implementing the WHO-recommended Option B+ protocol for prevention of vertical HIV transmission, there is a lack knowledge regarding influence exposure on adverse birth outcomes (ABOs). Against this background, we assessed ABOs among delivering women in Western Uganda.A cross-sectional, observational study was performed within cohort 412 mother-newborn-pairs Virika Hospital, Fort Portal 2013. The occurrence stillbirth, pre-term delivery, and...
Background WHO-guidelines for prevention of mother-to-child transmission HIV-1 in resource-limited settings recommend complex maternal antiretroviral prophylaxis comprising antenatal zidovudine (AZT), nevirapine single-dose (NVP-SD) at labor onset and AZT/lamivudine (3TC) during one week postpartum. Data on resistance development selected by this regimen is not available. We therefore analyzed the emergence minor drug-resistant variants Tanzanian women following prophylaxis. Method 1395...
Sierra Leone has one of the highest maternal mortality rates in world. Encouraging use skilled birth attendance health facilities is an important step endeavor to increase number safe deliveries. However, public trust been greatly damaged during Ebola epidemic outbreak 2014/2015, and little known about external intrinsic barriers facility-based delivery (FBD) country since end epidemic.We conducted a qualitative study on FBD Princess Christian Maternity Hospital, Freetown, which national...
The study attempted to determine the incidence of HIV among pregnant women in Kabarole District, Uganda, and identify socio-demographic behavioral risk factors for seroconversion during pregnancy.
Abstract Background In the African region, 5.6% of pregnancies are estimated to be complicated by preeclampsia and 2.9% eclampsia, with almost one in ten maternal deaths being associated hypertensive disorders. Sierra Leone, representing countries highest mortality rates world, 16% were caused pregnancy-induced hypertension 2016. light high burden eclampsia (PrE/E) we aimed at assessing population-based risk factors for PrE/E offer improved management women risk. Methods A facility-based,...
Introduction Tanzanian guidelines for prevention of mother-to-child-transmission HIV (PMTCT) recommend an antiretroviral combination regimen involving zidovudine (AZT) during pregnancy, single-dosed nevirapine at labor onset, AZT plus Lamivudine (3TC) delivery, and AZT/3TC 1–4 weeks postpartum. As drug toxicities are a relevant concern, we assessed hematological alterations in AZT-exposed women their infants. Methods Materials A cohort HIV-positive women, either with intake (n = 82, group 1)...