A5074896502- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- SARS-CoV-2 detection and testing
- Adolescent Sexual and Reproductive Health
- HIV-related health complications and treatments
- HIV/AIDS drug development and treatment
- Metabolism and Genetic Disorders
- Global Maternal and Child Health
- Respiratory viral infections research
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Water Access
- Infant Development and Preterm Care
- Acute Myeloid Leukemia Research
- HIV/AIDS oral health manifestations
- Pneumocystis jirovecii pneumonia detection and treatment
- COVID-19 diagnosis using AI
- COVID-19 epidemiological studies
- Retinoids in leukemia and cellular processes
- Advanced biosensing and bioanalysis techniques
- HIV/AIDS Impact and Responses
- Vaccine Coverage and Hesitancy
- Biosensors and Analytical Detection
Clinton Health Access Initiative
2018-2024
Objective: We measured the effect of point-of-care (POC) early infant HIV testing on antiretroviral therapy initiation rates and retention in care among infants Mozambique. Design: A cluster-randomized trial was conducted 16 primary healthcare centres providing either on-site POC arm (n = 8) or referred laboratory [standard-of-care (SOC) arm; n 8] testing. Methods: The outcomes were proportion HIV-positive initiating within 60 days sample collection, who initiated that retained at 90...
Background Failure to timely diagnose HIV in infants is a major barrier for scaling-up paediatric antiretroviral treatment (ART). WHO recommends birth testing earlier diagnosis and improve test coverage, but current takes 2–3 weeks complete, thereby limiting the ability of care givers provide follow-on care, especially low-resource settings. We evaluated benefit implementing rapid at primary health maternity wards Mozambique. Methods findings Infants born HIV-infected mothers delivering...
(1) Background: Laboratory-based molecular assays are the gold standard to detect SARS-CoV-2. In resource-limited settings, implementation of these has been hampered by operational challenges and long turnaround times. Rapid antigen detection tests an attractive alternative. Our aim is evaluate clinical performance two SARS-CoV-2 rapid during a high transmission period. (2) Methods: A total 1277 patients seeking diagnosis were enrolled at four health facilities. Nasopharyngeal swabs for real...
Timely viral load (VL) results during pregnancy and the postpartum period are crucial for HIV disease management preventing mother-to-child transmission. Point-of-care (POC) VL testing could reduce turnaround times streamline patient management. We evaluated diagnostic performance of novel m-PIMA HIV-1/2 assay (Abbott, Chicago, IL) in Mozambique.The study was conducted prenatal consultation rooms 2 primary health care clinics. Sample collection on were performed by trained...
Abstract Background We assessed the impact of point-of-care (PoC) test-and-treat at birth on clinical outcomes and viral suppression among human immunodeficiency virus (HIV)–positive infants in Mozambique Tanzania. Methods This cluster-randomized trial allocated health facilities to intervention, providing PoC testing antiretroviral treatment (ART) week 4–8, or control, starting these 4–8. The primary outcome was proportions events (mortality, morbidity, retention, virological failure,...
Background: In resource-poor countries, antigen-based rapid tests (Ag-RDTs) performed at primary healthcare and community settings improved access to SARS-CoV-2 diagnostics. However, the technical skills biosafety requirements inherent nasopharyngeal oropharyngeal (OP) specimens limit scale-up of testing. The collection nasal-swabs is programmatically viable, but its performance has not been evaluated in settings. Methods: We first SteriPack self-collected nasal swabs for detection by...
Abstract Patients with acute promyelocytic leukemia (APL), a subtype of myeloid (AML), often present severe leucocytosis and thrombocytopenia, which may lead to symptoms that require prompt diagnosis treatment. Immunophenotyping combined cytomorphology is valuable tool for identifying APL patients. We describe the case 9-year-old male patient who was diagnosed in July 2022 using immunophenotyping cytomorphology. The treated chemotherapy now full remission maintenance phase. This demonstrated...
Conventional diagnostic systems struggled to meet the fluctuating demand for testing across different waves of coronavirus disease 2019 (COVID-19) pandemic. This study aimed assess feasibility and effectiveness walkthrough (WT) approach in extending access COVID-19 high-risk populations traditionally underrepresented at health facilities (HFs) observe its impact on demand. An interventional was implemented markets (WT markets) ports ports) Maputo City Province, Mozambique. Demographic,...
Novel approaches to case identification and linkage antiretroviral therapy (ART) are needed close gaps in early infant diagnosis (EID) of HIV. Point-of-care (POC) EID is a recent innovation that eliminates the long turnaround times conventional limit patient management inpatient setting. The initial deployment POC Mozambique focused primarily on outpatient clinics; however, 2 high-volume tier-4 pediatric referral hospitals were also included.To assess impact EID, retrospective review testing...
Background: We assessed the impact of point-of-care (PoC) test-and-treat at birth on clinical outcomes and viral suppression among HIV-positive infants in Mozambique Tanzania. Methods: This cluster-randomized trial allocated public health facilities to intervention, providing PoC-early infant diagnosis antiretroviral treatment from birth, or control, starting these 4-8 weeks. The primary outcome was proportions events (mortality, morbidity, retention) 18 months. also estimated hazard ratios...
<h3>Background</h3> Roughly 1.3 million infants are exposed and 150,000 newly diagnosed with Human Immunodeficiency Virus (HIV) annually. Estimates of Vertical HIV transmission (VHT) rates vary by setting. In this study, we assessed the risk factors for VHT among born to women living in Tanzania Mozambique. <h3>Methods</h3> Between October 2019 August 2021, data was collected from pregnant who participated LIFE study [RIA2016MC] at 28 obstetric health facilities up month 3 age all infants....