A5052974348- Veterinary Oncology Research
- Blood groups and transfusion
- Infectious Diseases and Mycology
- Plant and animal studies
- Cancer-related gene regulation
- Platelet Disorders and Treatments
- Hemophilia Treatment and Research
- Cancer Research and Treatments
- Biochemical Analysis and Sensing Techniques
- melanin and skin pigmentation
- Erythrocyte Function and Pathophysiology
- Cell Adhesion Molecules Research
- Melanoma and MAPK Pathways
- Ecology and Vegetation Dynamics Studies
- Cancer Immunotherapy and Biomarkers
- Mast cells and histamine
- Bladder and Urothelial Cancer Treatments
- Hymenoptera taxonomy and phylogeny
- Bioenergy crop production and management
- Monoclonal and Polyclonal Antibodies Research
- Lysosomal Storage Disorders Research
- Virus-based gene therapy research
- Glycogen Storage Diseases and Myoclonus
- Genetics and Neurodevelopmental Disorders
- Wnt/β-catenin signaling in development and cancer
Laboklin (Germany)
2010-2024
Technical University of Munich
2023-2024
University of Tübingen
2013-2024
Helsinki Art Museum
2023
University of Helsinki
2023
Leipzig University
2023
Universitätsmedizin Rostock
2016
University of Bayreuth
2007-2010
Leibniz Centre for Agricultural Landscape Research
2007
Joensuu Science Park
2007
Anaplasma phagocytophilum is a gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals. In contrast to the United States, human granulocytic anaplasmosis seems be rare disease Europe despite initial recognition of A. as causative agent tick-borne fever European sheep cattle. Considerable strain variation has been suggested occur within this species, because isolates from animals differed their pathogenicity for...
Abstract Whereas temporal variability of plant phenology in response to climate change has already been well studied, the spatial is not understood. Given that phenological shifts may affect biotic interactions, there a need investigate how environmental factors relates herbaceous species’ by at same time considering their functional traits predict general and species-specific responses future change. In this project, we analysed records 148 species, which were observed for single year...
Molecular biomarkers are central to personalised medicine for human cancer patients. It is gaining traction as part of standard veterinary clinical practice dogs and cats with cancer. can be somatic or germline genomic alterations ascertained from tissues body fluids using various techniques. This review discusses how these determined the findings used in settings diagnostic, prognostic, predictive, screening biomarkers. We showcase currently available date testing a setting, discussing...
Abstract Canine urothelial carcinoma (UC) and prostate (PC) frequently exhibit the BRAF V595E mutation, akin to V600E mutation common in various human cancers. Since initial discovery of canine cancers 2015, PCR has been standard method for its detection both liquid tissue biopsies. Considering similarity between mutations, we hypothesized that immunohistochemistry (IHC) using a ‐specific antibody could effectively identify mutant protein. We tested 122 UC (bladder n = 108, urethra 14), 21...
Abstract Mammals are generally resistant to Mycobacterium avium complex (MAC) infections. We report here on a primary immunodeficiency disorder causing increased susceptibility MAC infections in canine breed. Adult Miniature Schnauzers developing progressive systemic were related common founder, and pedigree analysis was consistent with an autosomal recessive trait. A genome-wide association study homozygosity mapping using 8 infected, 9 non-infected relatives, 160 control detected...
Introduction Necrotizing meningoencephalitis (NME) in pugs is a potentially fatal disease, which needs lifelong treatment with immunosuppressive or immunomodulatory drugs and shares parallels acute fulminating multiple sclerosis. Genetic variants of the DLA class II gene are associated an increased risk for NME. testing recommended prior to breeding. The aim this study was describe current allele frequency previously identified NME variant European pug population. A secondary investigate...
Summary Coat colour dilution may be the result of altered melanosome transport in melanocytes. Loss‐of‐function variants melanophilin gene ( MLPH ) cause a recessively inherited form coat many mammalian and avian species including dog. corresponds to D locus domestic animals, recessive alleles at this are frequently denoted with d . In study, we investigated dilute coloured Chow Chows whose could not explained by their genotype previously known :c.–22G>A variant. Whole genome sequencing...
In domestic cats, the AB blood group system consists of three types A, B, and C (usually called AB), which vary in frequency among breeds geographic regions. Mismatches cause acute hemolytic transfusion reactions hemolysis newborn due to presence naturally occurring anti-A alloantibodies. Cytidine monophosphate-N-acetylneuraminic acid hydroxylase (CMAH) converts N-acetylneuraminic (type B) N-glycolylneuraminic A), type erythrocytes express both antigens. We examined feline CMAH coding...
Altered melanosome transport in melanocytes, resulting from variants the melanophilin (MLPH) gene, are associated with inherited forms of coat color dilution many species. In dogs, MLPH gene corresponds to D locus and two variants, c.−22G > A (d1) c.705G C (d2), leading color, as described. Here, we describe independent investigations dogs whose could not be explained by known who report a third variant, (c.667_668insC) (d3), which leads frameshift premature stop codon (p.His223Profs*41)....
Summary Loss‐of‐function variants in the MC 1R gene cause recessive red or yellow coat‐colour phenotypes many species. The canine :c.916C>T (p.Arg306Ter) variant is widespread and found a homozygous state uniformly yellow‐ red‐coloured dogs. We investigated cream‐coloured Australian Cattle Dogs whose coat colour could not be explained by this variant. A genome‐wide association study with 10 cream 123 confirmed that locus indeed maps to . Whole‐genome sequencing of dogs revealed single...
In dogs, the
Hereditary hyperekplexia is a rare neuronal disorder characterized by an exaggerated startle response to sudden tactile or acoustic stimuli. In this study, we present Miniature Australian Shepherd family showing clinical signs, which have genetic and phenotypic similarities with human hereditary hyperekplexia: episodes of muscle stiffness that could occasionally be triggered Whole genome sequence data analysis two affected dogs revealed 36-bp deletion spanning the exon-intron boundary in...
Abstract In this short report we discuss the temporal association between an acute life threatening event (ALTE) and a RT‐PCR confirmed coronavirus HCoV‐229E infection in 4 months old otherwise healthy infant. More detailed microbiological investigations of affected children even without apparent signs respiratory tract may help to clarify etiology some patients extend our understanding pathogenesis. PCR‐based techniques should be utilized increase sensitivity detection for new viral...
Urothelial carcinoma (UC) is the most common tumour of canine urinary bladder. Recently, BRAF mutation testing emerged as a diagnostic option, but its prognostic significance unknown. This study investigates relationship between (variant V595E) status and overall survival in UC-bearing dogs. Seventy-nine patients histologically diagnosed with UC bladder and/or urethra 2006 2019 were included this retrospective single-centre-study. Treatment consisted meloxicam (n = 39, group 1 'Melox'),...
Zusammenfassung Gegenstand und Ziel: Übergangszellkarzinome (ÜZCa) sind die häufigsten malignen Tumoren der harnableitenden Wege beim Hund. In früheren Studien wurde mittels DNA-Sequenzierung in Urinproben, Gefrier- Paraffinmaterial von Harnblasenbioptaten Mutation im BRAF-Gen V595E bei bis zu 85 % kaninen ÜZCa den Tumorzellen identifiziert. Ziel eigenen Arbeit war, diese Methode für zytologische Ausstriche etablieren Prävalenz dieser Kollektiv untersuchen. Material Methoden: Es wurden 43...
Canine digital melanoma, in contrast to canine oral is still largely unexplored at the molecular genetic level. The aim of this study was detect mutant genes melanoma. Paraffin-embedded samples from 86 melanomas were examined for BRAF V595E variant by droplet PCR (ddPCR), and exon 11 mutations c-kit. Furthermore, exons 2 3 KRAS NRAS analysed Sanger sequencing. Copy number variations (CNV) KITLG genomic DNA nine dogs. absent c-kit, a single nucleotide polymorphism found 16/70 tumours (23%)....
Summary In domestic cats, the AB blood group system consists of three types A, B and C (also called ). Mismatches can cause acute hemolytic transfusion reactions hemolysis newborn (neonatal isoerythrolysis, NI As are inherited recessively to breeders need know genotype predict in offspring avoid . Several CMAH variants have been described as being associated with b a c alleles, different genotyping schemes exist. Here, we genotyped 2145 cats original SNV panel, including s c.142G>A ∆‐53,...
Lafora disease (LD) is a genetic affecting beagles, resulting in seizures combination with other signs. The aim of this study was to describe the clinical signs LD beagles different NHLRC1 genotypes. One hundred and sixty-six were tested for an gene defect: L/L (n = 67), N/L 32), N/N 67). Owners asked participate survey about their dogs. These recorded three possible genotypes two age groups, <6 years ≥6 years. In all genotypes, nearly described. group ≥ 6 years, however, they significantly...
We investigated a syndromic disease comprising blindness and neurodegeneration in 11 Saarlooswolfdogs. Clinical signs involved early adult onset retinal degeneration adult-onset neurological deficits including gait abnormalities, hind limb weakness, tremors, ataxia, cognitive decline behavioral changes such as aggression towards the owner. Histopathology one affected dog demonstrated cataract, degeneration, central peripheral axonal severe astroglial hypertrophy hyperplasia nervous system....
Based upon previous clinical experience with domestic cats (Felis catus), the ability to assess ABC blood types and (in-)compatibilities of nondomestic felids, adequately consider plan for transfusions, may be important. Although felids appear have an group system similar cats, typing point-of-care kits by CMAH genotyping not been reported. In this study, 162 samples from 18 different felid species (cheetah [Acinonyx jubatus, n = 42], lion [Panthera leo, 33], tiger tigris, 23], Canada lynx...
Alterations of the