A5101978140- Neonatal Respiratory Health Research
- Infant Nutrition and Health
- Glycosylation and Glycoproteins Research
- Congenital Diaphragmatic Hernia Studies
- Pediatric Hepatobiliary Diseases and Treatments
- Pelvic floor disorders treatments
- Neuroscience of respiration and sleep
- Galectins and Cancer Biology
- Horticultural and Viticultural Research
- Genital Health and Disease
- Glioma Diagnosis and Treatment
- Craniofacial Disorders and Treatments
- Congenital Heart Disease Studies
- Metabolism and Genetic Disorders
- Genetics and Neurodevelopmental Disorders
- Congenital gastrointestinal and neural anomalies
- Cervical Cancer and HPV Research
- Gastrointestinal motility and disorders
- Genetic factors in colorectal cancer
- Microtubule and mitosis dynamics
- Infrared Thermography in Medicine
- Effects of Vibration on Health
- Clusterin in disease pathology
- Moyamoya disease diagnosis and treatment
- Birth, Development, and Health
Philipps University of Marburg
2022-2024
University Children's Hospital Tübingen
2024
Chiba Hospital
2023
Universitätsklinikum Erlangen
2023
Helsinki Art Museum
2023
University of Helsinki
2023
Leipzig University
2023
Medizinische Hochschule Hannover
2023
Friedrich-Alexander-Universität Erlangen-Nürnberg
2022
Saarland University
2021-2022
Background and Aims: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, the main causes are viral infections (12%–16%) inherited metabolic diseases (14%–28%). Yet, in up to 50% of cases underlying etiology remains elusive, challenging clinical management, including transplantation. We systematically studied indeterminate PALF referred for genetic evaluation by whole-exome sequencing (WES), analyzed phenotypic biochemical markers, diagnostic yield WES this...
Abstract Deleted in Malignant Brain Tumors 1 ( DMBT1 ) at chromosome region 10q25.3–q26.1 has been proposed as a candidate tumor‐suppressor gene for brain, digestive tract, and lung cancer. Recent studies on its expression cancer have led to divergent results raised controversial discussion. Moreover, implicated with epithelial protection the respiratory tract. We thus wondered how loss of could be related carcinogenesis lung. To address these issues, we investigated location normal By...
Deleted in malignant brain tumors 1 (DMBT1) belongs to the scavenger receptor cysteine-rich superfamily of proteins and is implicated innate immunity, cell polarity, differentiation. Here we studied role DMBT1 endothelial cells.DMBT1 was secreted into extracellular matrix (ECM) by cells vitro situ presence ECM increased adherence. Endothelial cell-derived associated with galectin-3 (coprecipitation), human recombinant bound EGF, vascular growth factor Delta-like (Dll) 4 (specific ELISAs)....
Deleted in malignant brain tumors 1 (DMBT1) is an innate defence protein expressed the lungs of preterm infants and adults. Recent studies showed that DMBT1 important angiogenesis can bind to different growth factors including VEGF. We aimed at examining relationships between VEGF IL-6 levels expression term lung epithelial cells vitro. examined by ELISA 120 tracheal aspirates 57 tested for correlation with perinatal as well levels. To examine effect on we compared type II A549 stably...
Abstract DMBT1 and galectin‐3 are potential interacting proteins with presumably complex roles in tumorigenesis. While at present a variety of mechanisms discussed for its participation cancer, is commonly known to exert tumor‐promoting effects. However, vitro studies rodent system have suggested that DMBT1/galectin‐3 interaction the ECM triggers epithelial differentiation, which would point tumor‐suppressive properties. To improve understanding action we carried out skin cancer different...
Abstract Deleted in malignant brain tumors 1 ( DMBT1 ) at 10q25.3–q26.1 has been proposed as a candidate tumor‐suppressor gene for and epithelial cancer. encodes multifunctional mucin‐like protein presumably involved differentiation protection. The consists of highly homologous repeating exon intron sequences. This specifically applies to the region coding repetitive scavenger receptor cysteine‐rich (SRCR) domains SRCR‐interspersed (SIDs) that constitutes major part gene. particular...
Hereditary hyperekplexia is a rare neuronal disorder characterized by an exaggerated startle response to sudden tactile or acoustic stimuli. In this study, we present Miniature Australian Shepherd family showing clinical signs, which have genetic and phenotypic similarities with human hereditary hyperekplexia: episodes of muscle stiffness that could occasionally be triggered Whole genome sequence data analysis two affected dogs revealed 36-bp deletion spanning the exon-intron boundary in...
Deleted in malignant brain tumors 1 (DMBT1) has been proposed as a candidate tumor suppressor for and epithelial cancer. Initial studies suggested loss of expression rather than mutation the predominant mode DMBT1 inactivation. However, situ lung cancer demonstrated highly sophisticated changes localization, pointing to chronological order events. Here we report on investigation breast test whether these principles might also be attributable other types. Comprehensive mutational analyses did...
Summary Deleted in Malignant Brain Tumours 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds and aggregates various bacteria viruses vitro. Studies adults have shown DMBT1 expressed mainly by mucosal epithelia glands, particular within the respiratory tract, plays role innate immune defence. We hypothesized levels may be influenced developmental clinical factors such as maturity, age bacterial infection. were studied 205 tracheal aspirate samples of 82 ventilated...
Abstract Background Even if understanding of neuronal enteropathies, such as Hirschsprung's disease and functional constipation, has been improved, specialized therapies are still missing. Sacral neuromodulation (SNM) established in the treatment defecation disorders adults. The aim study was to investigate effects SNM children adolescents with refractory symptoms chronic constipation. Methods A two‐centered, prospective trial conducted between 2019 2022. applied continuously at individually...
Deleted in Malignant Brain Tumors 1 (DMBT1) is a secreted scavenger receptor cysteine-rich protein that binds various bacteria and thought to participate innate pulmonary host defense. We hypothesized DMBT1 could contribute respiratory distress syndrome neonates by modulating surfactant function.DMBT1 expression was studied immunohistochemistry mRNA situ hybridization post-mortem lungs of preterm full-term with hyaline membranes. The effect human recombinant on the function bovine porcine...
Abstract Background Human milk contains immune molecules involved in the protection of newborns against infections. We analyzed concentration Deleted Malignant Brain Tumors 1 (DMBT1), a protein with functions innate immunity, breast milk. Methods DMBT1 was detected by Western blotting and its quantified ELISA 95 samples collected from mothers preterm term neonates during first four weeks after delivery. Possible effects maternal or neonatal parameters were different statistical tests....
In adult patients with chronic refractory constipation, invasive sacral neuromodulation (SNM) has been applied successfully. There is a need for less solutions while providing comparable therapeutic effects in children and adolescents. We present prospective, interventional case-control study on the application of noninvasive SNM.Patients constipation to conservative treatment were prospectively included from 2018 2021 randomized either SNM (SNM group: single current stimulation 24 h/d,...
Necrotizing enterocolitis (NEC) continues to cause high morbidity and mortality. Identifying early predictors for severe NEC is essential improve therapy optimize timing surgical intervention. We present a retrospective study of patients with NEC, treated between 2010 2020, trying identify factors influencing the severity NEC. Within period, 88 affected infants or NEC-like symptoms are analyzed. A multiple logistic regression analysis reveals following three independent in Bell stage III:...
Deleted in malignant brain tumors 1 (DMBT1) is involved innate immunity and epithelial differentiation. It has been proven to play a role various states of inflammation or hypoxia fetal gastrointestinal pulmonary diseases. Discrimination pathogenesis necrotizing enterocolitis (NEC) based on cardiac status improves the understanding NEC different patient subgroups. We aimed at examining DMBT1 expressions regarding their association with leading impaired intestinal perfusion, intraoperative...