A5020929898- Neonatal Respiratory Health Research
- Immune Response and Inflammation
- Sociology and Education Studies
- Sepsis Diagnosis and Treatment
- Biomedical and Chemical Research
- Neonatal and Maternal Infections
- Orthodontics and Dentofacial Orthopedics
- Blood Coagulation and Thrombosis Mechanisms
- Medical and Biological Sciences
- Neuroscience of respiration and sleep
- Educational Philosophies and Pedagogies
- Psychoanalysis and Social Critique
- Drug Transport and Resistance Mechanisms
- Cell Adhesion Molecules Research
- Trauma Management and Diagnosis
- Temporomandibular Joint Disorders
- Kantian Philosophy and Modern Interpretations
- Infant Health and Development
- Craniofacial Disorders and Treatments
- Infant Nutrition and Health
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Folate and B Vitamins Research
- NF-κB Signaling Pathways
- Orthopedic Surgery and Rehabilitation
- Migraine and Headache Studies
Kinderkrebs-Zentrum Hamburg
2024
MSH Medical School Hamburg – University of Applied Sciences and Medical University
2024
University Children's Hospital Tübingen
2023
Asklepios Klinik Langen
2020
Katholisches Kinderkrankenhaus Wilhelmstift
2014-2015
Heidelberg University
2007-2015
University Hospital Heidelberg
2007-2015
Mid Yorkshire Hospitals NHS Trust
2013
Dewsbury and District Hospital
2011-2012
University of Bayreuth
2011
Importance The effects of probiotic interventions on colonization with resistant bacteria and early microbiome development in preterm infants remain to be clarified. Objective To examine the efficacy Bifidobacterium longum subsp infantis , animalis lactis (BB-12), Lactobacillus acidophilus (La-5) probiotics prevent multidrug-resistant organisms or highly epidemic (MDRO+) shape toward eubiotic state healthy full-term infants. Design, Setting, Participants multicenter, double-blinded,...
As nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs) seem to be critical mediators in the inflammatory response, we studied effects of lipopolysaccharide (LPS) lipoteichoic acid (LTA) on (a) activation NF-κB MAPKs (b) expression tumor necrosis alpha (TNF-α) interleukin 6 (IL-6) with or without specific inhibitors these intracellular signal transduction pathways neonatal cord adult blood. TNF-α IL-6 concentrations showed a sharp increase supernatants whole blood...
<h3>Importance</h3> More than half of patients who undergo knee replacement surgery report substantial acute postoperative pain. <h3>Objective</h3> To evaluate the efficacy and cost-effectiveness periarticular liposomal bupivacaine for recovery pain management after replacement. <h3>Design, Setting, Participants</h3> This multicenter, patient-blinded, pragmatic, randomized clinical superiority trial involved 533 participants at 11 institutions within National Health Service in England....
An increasing number of elderly patients are managed with long-term antiplatelet therapy. Such often present hip fracture requiring surgical intervention and may be at increased risk perioperative bleeding complications. The aim this study was to ascertain whether it is necessary stop clopidogrel preoperatively avoid postoperative complications following hemiarthroplasty surgery in intracapsular fracture.A retrospective review 102 either therapy [clopidogrel group (CG)] or no previous...
Abstract Background Infections are highly relevant for neonatal mortality and long-term morbidities in survivors. Therefore, it is an urgent need to optimize evaluate infection prevention control (IPC) strategies. Several outbreaks German intensive care units (NICUs) required rapid responses by hospitals improved future preparedness. As a consequence, authorities recommended weekly colonization screening on NICUs. This aims detect multidrug-resistant organisms (MDRO) bacteria with high...
The objective of the present study was to detect possible associations between unilateral crossbite and orthopaedic disturbances in children with asymmetry upper cervical spine. Fifty-five aged 3-10 years (22 girls 33 boys) a 55 gender- age-matched symmetric occlusion but no crossbite, who served as control group, were selected from an cohort 240 patients. In all children, region confirmed by radiographs palpation. following aspects investigated: oblique shoulder pelvis, scoliosis,...
Bacterial infections, even without any perinatal risk factors, are common in newborns, especially preterm neonates. The aim of this study was to evaluate possible impairment neutrophil chemotaxis term and neonates compared with adults as well different modes delivery anaesthesia. We analysed the expression adhesion molecule L-Selectin shape change, spontaneous N-formyl-methionyl-leucyl-phenylalanine (fMLP)-induced transmigration neutrophils a flow cytometric assay after Cesarian Section (CS)...
Though various neurohormonal systems are concurrently activated during birth, their biological effectors not always easy to measure due short half-life in vivo, instability samples, or very low concentrations.Using a recently discovered chemiluminescence assay, we measured the stable precursor fragments mid-regional pro-atrial natriuretic peptide (MR-proANP), pro-adrenomedullin (MR-proADM), C-terminal pro-endothelin-1 (CT-proET-1) and pro-vasopressin (CT-proAVP copeptin) immediately after...
Aims The receptor for advanced glycation endproducts, RAGE, is a multiligand and NF-κB activator leading to perpetuation of inflammation. We investigated whether how RAGE involved in mediation anti-inflammatory properties protein C. Methods Results analyzed the effect C on leukocyte adhesion transmigration WT- RAGE-deficient mice using intravital microscopy cremaster muscle venules during trauma- TNFα-induced Both, (PC, Ceprotin, 100 U/kg) activated (aPC, 24 µg/kg/h) treatment significantly...
<i>Background:</i> Sepsis continues to be a leading cause of morbidity and mortality in newborns. <i>Objective:</i> As both nuclear factor-kappa B (NF-ĸB) p38 mitogen-activated protein kinase (MAPK) appear critical mediators inflammatory response, we studied the effects lipopolysaccharide (LPS) on expression function NF-ĸB MAPK whole neonatal cord adult blood. <i>Methods:</i>Th1/Th2 cytokine concentrations phosphorylation were determined by flow-cytometric...
Objectives: Efficacy of multistrain probiotic with Bifidobacterium (B.) longum subsp. infantis, animalis lactis (BB-12), and Lactobacillus acidophilus (La-5) to prevent colonisation multidrug-resistant organisms or highly epidemic bacteria (MDRO+) shape the microbiome preterm infants towards eubiosis. Design, Setting, Participants: Multicenter, randomized, double-blinded, placebo-controlled, adaptive phase 3 trial (the PRIMAL trial) including 643 a gestational age 28 32 weeks at 18 German...
It is well acknowledged that proinflammatory stimulation during acute hyperglycemia able to aggravate inflammatory diseases. However, the mechanisms of effects glucose are controversially discussed. We investigated leukocyte recruitment after intravenous injection in different models using intravital microscopy. Flow chamber experiments, expression analysis, functional depletion, and knockout key adhesion molecules gave mechanistic insight involved pathways. demonstrated a single rapidly...
<i>Background:</i> Neonatal Gram-negative sepsis is often characterized by a fulminant clinical course, compared to adults, resulting in higher morbidity and mortality. Genome-wide gene expression analysis can provide insights into the molecular alterations sepsis. <i>Objectives:</i> To evaluate vitro activation of neonatal adult immune system, patterns were mononuclear cells from cord (CBMNC) peripheral blood (APBMNC). <i>Methods:</i> better understand...
There are several reports demonstrating an involvement of bacterial toxins in the rigidity red blood cells (RBC). The present study investigates influence E. coli F-583-Rd lipid A on RBC deformability under mechanical shear stress. Verapamil (Ca(2+) channel inhibitor), staurosporine (protein kinase inhibitor) and Y-27632 (rho-kinase were used to modify effect deformability. We also determined if Lipid could induce increase intracellular Ca(2+) concentration. For deformation measurements (10...
Abstract Background Human milk contains immune molecules involved in the protection of newborns against infections. We analyzed concentration Deleted Malignant Brain Tumors 1 (DMBT1), a protein with functions innate immunity, breast milk. Methods DMBT1 was detected by Western blotting and its quantified ELISA 95 samples collected from mothers preterm term neonates during first four weeks after delivery. Possible effects maternal or neonatal parameters were different statistical tests....